{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:33:59Z","timestamp":1786739639316,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Inadequate pain control can cause a delay in recovery; hence, adequate analgesia is of much importance. The thoracolumbar interfascial plane (TLIP) block is a relatively newer block which has shown promising effects in pain control. In this study, we aim to determine the efficacy and safety of dexmedetomidine in enhancing the impact of local anaesthetic in TLIP block in patients undergoing lumbar surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      60 patients aged 18\u201370 years were randomised to Group Plain [modified TLIP block with 20 mL of 0.25% ropivacaine bilaterally with general anaesthesia (GA)] and Group Dexmed (modified TLIP block with 0.25% ropivacaine along with 0.5 \u00b5g\/kg dexmedetomidine bilaterally with GA). The primary outcome was to assess the total perioperative opioid consumption in the first 24 h. The secondary outcomes were to assess pain score upon arriving in the post-anaesthesia care unit, time to first analgesic need after surgery, postoperative opioid consumption in 24 h, and incidence of adverse events, including nausea and vomiting. Continuous variables were analysed using an independent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test. The variables which had a non-normal distribution were analysed using the Mann\u2013Whitney U test. Paired continuous data following a normal distribution were analysed using the Paired T-test. Categorical variables were analysed using the Chi-square test. The statistical analysis was performed using Jamovi 2.4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The total perioperative opioid consumption in Group Plain was 653.33 [standard deviation (SD): 250.4 \u00b5g] and that in Group Dexmed was 523.6 (SD: 258.6 \u00b5g), with a mean difference of 129.67 [95% confidence interval (CI): -1.89, 261.22] (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.053). However, the first request for analgesia was significantly prolonged in the Group Dexmed with a median of 180 minutes [interquartile range (IQR): 97.50\u2013232.50; range (Min\u2013Max: 30\u2013360) min] vs 90 minutes in Group Plain [(IQR):45\u2013120; range (Min\u2013Max: 15\u2013360) min],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001. Postoperative pain scores were comparable between both groups at different time points in 24 hours, except at 0 h rest and movement, and 3h at movement. The median highest postoperative nausea and vomiting (PONV) scores within the 24 h postoperative period did not differ significantly between the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.073).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>TLIP block with dexmedetomidine as an adjuvant did not decrease cumulative fentanyl consumption as compared to TLIP block with ropivacaine alone. But the time to first request of analgesia was increased in the Group Dexmed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_1093_25","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:00:15Z","timestamp":1769778015000},"page":"S59-S66","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of analgesic efficacy of ropivacaine versus ropivacaine plus dexmedetomidine in modified thoracolumbar interfascial plane block in patients undergoing lumbar disc surgeries: A randomised controlled trial"],"prefix":"10.4103","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6853-0392","authenticated-orcid":false,"given":"Siddhavivek","family":"Majage","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9209-5673","authenticated-orcid":false,"given":"Vanlal","family":"Darlong","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-306X","authenticated-orcid":false,"given":"Ravinder Kumar","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-7039","authenticated-orcid":false,"given":"Dalim Kumar","family":"Baidya","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9243-9963","authenticated-orcid":false,"given":"Puneet","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3169-6437","authenticated-orcid":false,"given":"Bhavuk","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"R1-20260130","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.2147\/IJGM.S292698","article-title":"Management of postoperative pain in patients following spine 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postoperative nausea and vomiting in women undergoing myomectomy under spinal anaesthesia","volume":"17","author":"Tobi","year":"2014","journal-title":"Niger J Clin Pract"},{"key":"R9-20260130","doi-asserted-by":"crossref","first-page":"815","DOI":"10.4103\/ija.ija_1147_23","article-title":"A randomised controlled trial to compare the occurrence of postoperative nausea and vomiting in early versus conventional feeding in children undergoing daycare surgery under general anaesthesia","volume":"68","author":"Singh","year":"2024","journal-title":"Indian J Anaesth"},{"key":"R10-20260130","doi-asserted-by":"crossref","first-page":"e7967","DOI":"10.7717\/peerj.7967","article-title":"Evaluation of ultrasound-guided lateral thoracolumbar interfascial plane block for postoperative analgesia in lumbar spine fusion surgery: A prospective, randomized, and controlled clinical trial","volume":"7","author":"Chen","year":"2019","journal-title":"PeerJ"},{"key":"R11-20260130","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4103\/ija.ija_1054_21","article-title":"Comparison of thoracolumbar interfascial plane block with local anaesthetic infiltration in lumbar spine surgeries: A prospective double-blinded randomised controlled trial","volume":"66","author":"Pavithran","year":"2022","journal-title":"Indian J Anaesth"},{"key":"R12-20260130","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.2147\/JPR.S329158","article-title":"Effect of ultrasound-guided thoracolumbar interfascial plane block on the analgesic requirements in patients undergoing lumbar spine surgery under general anesthesia: A randomized controlled trial","volume":"14","author":"Eltaher","year":"2021","journal-title":"J Pain Res"},{"key":"R13-20260130","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s40122-021-00295-4","article-title":"Comparison of two ultrasound-guided plane blocks for pain and postoperative opioid requirement in lumbar spine fusion surgery: A prospective, randomized, and controlled clinical trial","volume":"10","author":"Wang","year":"2021","journal-title":"Pain Ther"},{"key":"R14-20260130","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2147\/DDDT.S444485","article-title":"Comparative study between dexmedetomidine with bupivacaine and bupivacaine alone in erector spinae plane block for postoperative pain control of posterior lumbosacral spine fixation surgeries: A randomized controlled trial","volume":"18","author":"Abu","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"R15-20260130","doi-asserted-by":"crossref","first-page":"577885","DOI":"10.3389\/fmed.2021.577885","article-title":"The efficacy and safety of ultrasound-guided, bi-level, erector spinae plane block with different doses of dexmedetomidine for patients undergoing video-assisted thoracic surgery: A randomized controlled trial","volume":"8","author":"Gao","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"R16-20260130","doi-asserted-by":"crossref","first-page":"1326566","DOI":"10.3389\/fmed.2024.1326566","article-title":"Dexmedetomidine with different concentrations added to local anaesthetics in erector spinae plane block: A meta-analysis of randomised controlled trials","volume":"11","author":"Li","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"R17-20260130","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12891-022-05198-9","article-title":"Dexmedetomidine combined with ropivacaine for erector spinae plane block after posterior lumbar spine surgery: A randomized controlled trial","volume":"23","author":"Yi-Han","year":"2022","journal-title":"BMC Musculoskelet Disord"},{"key":"R18-20260130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12871-023-02014-2","article-title":"The role of dexmedetomidine as an adjuvant for high-thoracic erector 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History"}},{"value":"2025-11-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}