{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:34:00Z","timestamp":1786739640100,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>With the evolution of liver transplant anaesthesia, judicious intraoperative fluid management has been widely recommended. However, existing literature on a weight-based restricted fluid strategy is limited. Our institution follows a weight-based, restrictive fluid approach with maintenance therapy at 4 ml\/kg\/h (2 ml\/kg\/h crystalloids + 2 ml\/kg\/h 4% albumin solution) and goal-directed fluid boluses (4 ml\/kg 4% albumin solution).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study analysed 106 adult living donor liver transplant recipients managed with a protocolised restrictive fluid strategy and compared them with 148 historical controls who received conventional fluid therapy. The primary outcomes were early extubation (extubated on table or within 6 hours post-operatively) and incidence of post-operative acute kidney injury (AKI) on post-operative days (POD) 1 and 3. Secondary outcomes included intra-operative blood transfusion requirement, vasopressor use, and vascular complication rate. Data were analysed using statistical package for the social sciences version 22 and Epi Info version 7.2.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The restrictive group received significantly lower total fluid volumes (3284 \u00b1 833 ml vs. 3979 \u00b1 1524 ml;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), had higher on-table extubation rates (83% vs. 71.3%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.031), and experienced zero AKI by POD3 compared to 13.6% in the conventional group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Serum creatinine was lower on POD1 and POD3 in the restrictive group. Vasopressin use was higher (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) in the cases, while noradrenaline and blood transfusion requirements were comparable between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our protocolised weight-based restrictive fluid regimen was associated with improved pulmonary outcomes without increased renal dysfunction. However, prospective studies with larger cohorts are required to validate our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_1196_25","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:00:30Z","timestamp":1769778030000},"page":"S33-S41","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Intra-operative restricted fluid therapy in adult living donor liver transplant \u2013 Insights from a single-centre historical cohort study"],"prefix":"10.4103","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-084X","authenticated-orcid":false,"given":"Prachi","family":"Gokula","sequence":"first","affiliation":[{"name":"Department of Liver Transplant and HPB Anaesthesia, BLK-Max Superspeciality Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-533X","authenticated-orcid":false,"given":"Amit K.","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant and HPB Anaesthesia, BLK-Max Superspeciality Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6855-044X","authenticated-orcid":false,"given":"Gaurav","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant and HPB Anaesthesia, BLK-Max Superspeciality Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-239X","authenticated-orcid":false,"given":"Nitin","family":"Shanker","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant and HPB Anaesthesia, BLK-Max Superspeciality Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8885-0656","authenticated-orcid":false,"given":"Sachin","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Liver Transplant and HPB Anaesthesia, BLK-Max Superspeciality Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-4336","authenticated-orcid":false,"given":"Abhideep","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery and Liver Transplantation, BLK-Max Superspeciality Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"R1-20260130","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1017\/S0029665110001734","article-title":"A meta-analysis of randomised controlled trials of intravenous fluid therapy in major elective 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