{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:28:36Z","timestamp":1787228916588,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>\n                      Preoxygenation with 100% oxygen is associated with absorption atelectasis. This study compared 80% and 100% fractional inspired oxygen concentration (FiO\n                      <jats:sub>2<\/jats:sub>\n                      ) for the time to achieve adequate preoxygenation, defined by end-tidal oxygen (EtO\n                      <jats:sub>2<\/jats:sub>\n                      ). Secondary outcomes included the incidence of postoperative atelectasis, proportion of patients requiring more than 3 minutes for preoxygenation, haemodynamic changes, and desaturation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Two-hundred patients for general anaesthesia were randomly divided into either Group I or Group S, the intervention and the standard practice groups, and were preoxygenated with 80% and 100% FiO\n                      <jats:sub>2<\/jats:sub>\n                      , respectively. The time taken to reach an EtO\n                      <jats:sub>2<\/jats:sub>\n                      of 10% below the administered FiO\n                      <jats:sub>2<\/jats:sub>\n                      was considered the time to adequate preoxygenation. A lung ultrasonography was performed at baseline and again immediately after extubation. Independent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test or Mann\u2013Whitney U test and the Chi-square test were used for continuous and nominal categorical data, respectively. Non-inferiority was concluded if the lower bound of the confidence interval remained above the predefined non-inferiority margin of -15 seconds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The median preoxygenation time was comparable between groups: 95 s [interquartile range (IQR) 70\u2013133] and 99.5 s (IQR 80.3\u2013140) in Group I and S, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.484; 95% confidence interval \u221221 to 11). Non-inferiority was not demonstrated. The effect size was small (r = \u22120.096), indicating minimal clinical difference. However, atelectasis was significantly higher in Group S (31.9%) compared to Group I (8.6%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Non-inferiority of FiO\n                      <jats:sub>2<\/jats:sub>\n                      80% with 100% could not be established within the prespecified margin, though the median time to achieve adequate preoxygenation was comparable.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_216_26","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:00:48Z","timestamp":1787227248000},"page":"898-904","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A randomised trial comparing 80% and 100% inspired oxygen concentrations for time to adequate preoxygenation using end-tidal oxygen concentration targets"],"prefix":"10.4103","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0954-8297","authenticated-orcid":false,"given":"G Venkata","family":"Poornima","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, ESIC Medical College, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0729-8981","authenticated-orcid":false,"given":"A Chaitanya","family":"Pratyusha","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9284-0020","authenticated-orcid":false,"given":"CH Rama Krishna","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5782-3716","authenticated-orcid":false,"given":"Ramachandran","family":"Gopinath","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, ESIC Medical College, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-6947","authenticated-orcid":false,"given":"Rama Krishna","family":"Ravula","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Nizam\u2019s Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1164-1388","authenticated-orcid":false,"given":"R","family":"Sharanya","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, RIMS, Adilabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"R1-20260820","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.4103\/ija.ija_1210_25","article-title":"All India difficult airway association 2025 guidelines for the management of unanticipated difficult airway in adults under general anaesthesia","volume":"69","author":"Myatra","year":"2025","journal-title":"Indian J Anaesth"},{"key":"R2-20260820","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1213\/ANE.0000000000001589","article-title":"Preoxygenation: Physiologic basis, benefits, and 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