{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:40:35Z","timestamp":1789533635610,"version":"build-2803163510"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Laparoscopy is associated with acute pain. We compared the effectiveness of intra-peritoneal dexamethasone with bupivacaine versus bupivacaine in patients undergoing laparoscopic cholecystectomy for postoperative analgesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This randomised study was conducted after approval from the institutional ethics committee and 84 patients were randomly allocated into bupivacaine with dexamethasone group (BD) (received 40 mL of 0.25% bupivacaine with 16 mg dexamethasone), and bupivacaine group (BB) (received 40 mL of 0.25% bupivacaine intra-peritoneally). Data analysis was done using R version 4.2.1. The visual analogue scale (VAS) score, total rescue analgesic dose, and time required for the first analgesic between groups were compared using the Wilcoxon rank sum test or\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test appropriately.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      VAS score was significantly lower in the BD group compared to the BB group until 2 h post-operatively with a mean difference of \u2212 1.0 (95% confidence interval [CI] \u22121.5, \u22120.53),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001. The total rescue analgesic dose consumed was lower in the BD group (60.71 mg [29.80]) compared to the BB group (73.20 mg [11.57]) with a mean difference of \u2212 12.5 mg (95% CI \u2212 22.3, \u22122.68),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.013. In addition, the time taken for the requirement of the first rescue analgesic was significantly longer in the BD group (417.1 min [276.0]) compared to the BB group (219.4 min [226.1]) with a mean difference of 197.7 (95% CI 75, 320),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Intra-peritoneal instillation of 16 mg dexamethasone with 0.25% bupivacaine in laparoscopic cholecystectomy significantly reduces post-operative pain and requirement of rescue analgesic compared to 0.25% bupivacaine alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_275_23","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T13:00:24Z","timestamp":1699102824000},"page":"999-1003","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Analgesic efficacy of intra-peritoneal instillation of dexamethasone and bupivacaine versus bupivacaine following laparoscopic cholecystectomy \u2013 A randomised, double-blind controlled study"],"prefix":"10.4103","volume":"67","author":[{"given":"Pakhare","family":"Vandana","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda","family":"Ananya","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Muralikrishna","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supraja","family":"Ponduru","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyshnavi","family":"Renganathan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramchandran","family":"Gopinath","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, ESIC Medical College and Hospital, Hyderabad, Telangana, 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