{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:19:05Z","timestamp":1793045945950,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>The effect of a single intraoperative dose of steroids on perioperative blood sugar levels is uncertain. We hypothesised that a single dose of dexamethasone would not unfavourably alter the glucose levels of non-diabetic patients. This study aimed to evaluate the post-operative glycaemic profile after a single dose of intraoperative dexamethasone in non-diabetic patients. The presence of post-operative nausea and vomiting (PONV), pain, surgical site infection (SSI) and length of hospital stay were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This randomised, double-blind, controlled study was done by recruiting 150 non-diabetic adult patients of the American Society of Anesthesiologists physical status I\/II undergoing elective surgery. Patients in the study group were administered a single dose of dexamethasone (0.15 mg\/kg). Blood glucose levels were assessed at various time points for up to 72 hours post-operatively using point-of-care testing. Secondary outcomes such as PONV, pain, fever and SSI were also documented. Data were compared and analysed using Student\u2019s t-test, Chi-square test, Mann-Whitney test and analysis of variance test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was an earlier, higher and prolonged elevation in blood glucose levels in patients receiving dexamethasone. The mean (standard deviation) of fasting\/postprandial blood sugars on the first, second and third postoperative days respectively was significantly higher in the study group 98.04 (21.89)\/139.16 (20.59), 96.64 (19.20)\/138.17 (18.05), 96.60 (17.40)\/138.32 (15.10) mg\/dl as compared to control group 86.9 6 (10.28)\/128.95 (10.53), 88.81 (8.87)\/131.97 (9.68), 88.16 (8.50)\/130.88 (9.48) mg\/dl. About 10.7% of the patients who received dexamethasone had blood glucose levels greater than 180 mg\/dl. There were no significant differences in the secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Even a single dose of dexamethasone in non-diabetic adults causes significant and prolonged postoperative hyperglycaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_332_22","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T02:48:27Z","timestamp":1668653307000},"page":"789-795","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Effect of a single intraoperative dose of dexamethasone on glycaemic profile in postoperative patients - A double-blind randomised controlled study"],"prefix":"10.4103","volume":"66","author":[{"given":"Vigil","family":"Peter","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Jubilee Mission Medical College and Regional Institute, Thrissur, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Jubilee Mission Medical College and Regional Institute, Thrissur, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buena","family":"Rukkiyabeevi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Jubilee Mission Medical College and Regional Institute, Thrissur, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"B1-20240902","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.4239\/wjd.v6.i8.1073","article-title":"Steroid hyperglycemia:Prevalence, early detection and therapeutic recommendations:A narrative review","volume":"6","author":"Tamez-P\u00e9rez","year":"2015","journal-title":"World J Diabetes"},{"key":"B2-20240902","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s43440-021-00234-2","article-title":"Incidence and control of steroid induced hyperglycemia in hospitalized patients at a tertiary care centre for lung diseases","volume":"73","author":"Matej","year":"2021","journal-title":"Pharmacol Rep"},{"key":"B3-20240902","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fmed.2019.00054","article-title":"Stress hyperglycemia in critically ill patients:Insight into possible molecular pathways","volume":"6","author":"Bar-Or","year":"2019","journal-title":"Front Med"},{"key":"B4-20240902","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4158\/EP-2019-0252","article-title":"The effects of perioperative dexamethasone on glycemic control and postoperative outcome","volume":"26","author":"Herbst","year":"2020","journal-title":"Endocr Pract"},{"key":"B5-20240902","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/00008506-200404000-00003","article-title":"Effect of single dose of dexamethasone on blood glucose concentration in patients undergoing craniotomy","volume":"16","author":"Pasternak","year":"2004","journal-title":"J Neurosurg Anesthesiol"},{"key":"B6-20240902","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2174\/2589645801913010078","article-title":"Evaluating the effect of intraoperative dextrose 10% administration on reducing postoperative nausea and vomiting after laparoscopic surgery","volume":"13","author":"Ashraf","year":"2019","journal-title":"Open Anesth J"},{"key":"B8-20240902","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2337\/cd22-as01","article-title":"Standards of Medical Care in Diabetes-2022 Abridged for Primary Care Providers (American Diabetes Association)","volume":"40","year":"2022","journal-title":"Clin Diabetes"},{"key":"B9-20240902","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/bja\/aet010","article-title":"Does dexamethasone induced hyperglycemia contribute to postoperative morbidity and mortality?","volume":"110","author":"Dhatariya","year":"2013","journal-title":"Br J Anaesth"},{"key":"B10-20240902","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/anae.12309","article-title":"Routine use of dexamethasone for postoperative nausea and vomiting:The case against","volume":"68","author":"Bartlett","year":"2013","journal-title":"Anesthesia"},{"key":"B11-20240902","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/EJA.0000000000001294","article-title":"Perioperative ADministration of Dexamethasone And blood Glucose concentrations in patients undergoing elective non-cardiac surgery - the randomised controlled PADDAG trial","volume":"38","author":"Corcoran","year":"2021","journal-title":"Eur J Anaesthesiol"},{"key":"B12-20240902","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/aer.AER_21_20","article-title":"Effects of single dose of dexamethasone on perioperative blood glucose levels in patients receiving surgery for supratentorial tumors-An observational study","volume":"14","author":"Ali","year":"2020","journal-title":"Anesth Essays Res"},{"key":"B13-20240902","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/anae.13544","article-title":"The effect of antiemetic doses of dexamethasone on postoperative blood glucose levels in non-diabetic and diabetic patients:A prospective randomized controlled study","volume":"71","author":"Tien","year":"2016","journal-title":"Anesthesia"},{"key":"B14-20240902","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jclinane.2016.11.012","article-title":"Dexamethasone and perioperative blood glucose in patients undergoing total joint arthroplasty:A retrospective study","volume":"37","author":"Nurok","year":"2017","journal-title":"J Clin Anesth"},{"key":"B15-20240902","first-page":"1","article-title":"Dexamethasone and postoperative hyperglycemia in diabetics undergoing elective hip or knee arthroplasty:A case control study in 238 patients","volume":"12","author":"O'Connell","year":"2018","journal-title":"Patient Saf Surg"},{"key":"B16-20240902","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jopan.2021.10.005","article-title":"Perioperative dexamethasone for patients with diabetes and its effect on blood glucose after surgery","volume":"37","author":"Bonilla","year":"2022","journal-title":"J Perianesth Nurs"},{"key":"B17-20240902","first-page":"1","article-title":"Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery:Randomized controlled trial (DREAMS trial)","volume":"357","year":"2017","journal-title":"BMJ"},{"key":"B18-20240902","doi-asserted-by":"crossref","first-page":"668","DOI":"10.4103\/ija.IJA_159_20","article-title":"Analgesic sparing effect of dexamethasone with levobupivacaine in quadratus lumborum block in patients undergoing unilateral inguinal hernia repair:A prospective randomised controlled trial","volume":"64","author":"Singariya","year":"2020","journal-title":"Indian J Anaesth"},{"key":"B19-20240902","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/ALN.0000000000001515","article-title":"Perioperative hyperglycemia management:An update","volume":"126","author":"Duggan","year":"2017","journal-title":"Anesthesiology"},{"key":"B20-20240902","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12020-017-1398-y","article-title":"The impact of perioperative dexamethasone administration on the normal hypothalamic pituitary adrenal response to major surgical procedures","volume":"58","author":"El-Sibai","year":"2017","journal-title":"Endocrine"},{"key":"B21-20240902","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4103\/ija.IJA_119_21","article-title":"Effect of combinations of dexamethasone-ondansetron and dexamethasone-ondansetron-aprepitant versus aprepitant alone for early postoperative nausea and vomiting after day care gynaecological laparoscopy:A randomised clinical trial","volume":"65","author":"Thanuja","year":"2021","journal-title":"Indian J Anaesth"},{"key":"B22-20240902","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa2028982","article-title":"Dexamethasone and surgical site infection","volume":"384","author":"Corcoran","year":"2021","journal-title":"N Engl J Med"}],"container-title":["Indian Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ija.ija_332_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:15:11Z","timestamp":1787757311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ija.ija_332_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ija.ija_332_22","relation":{},"ISSN":["0019-5049","0976-2817"],"issn-type":[{"value":"0019-5049","type":"print"},{"value":"0976-2817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-04-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}