{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:11Z","timestamp":1786650071178,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Despite evidence that local intracuff alkalinised lignocaine may reduce the incidence of exaggerated laryngeal reflexes after thyroid surgery, its effects on the quality of recovery (QoR) from anaesthesia remain unknown. This study aimed to test if local intracuff alkalinised lignocaine improves the QoR from anaesthesia after thyroid surgery compared to placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients over 45 years old scheduled for thyroid surgery with electromyographic monitoring under general anaesthesia were enroled in a randomised, single-centre, double-blind, placebo-controlled trial. They were randomised into three groups (1:1:1 ratio): intravenous lignocaine (IVL), topical and intracuff lignocaine (TL), and placebo. The sample size was initially set at 231, but the study was terminated early after an interim analysis of 110 patients showed no significant difference between groups. The primary outcome was the QoR-40 score 24 hours post-surgery. Secondary outcomes included rates of arterial hypotension, coughing during emergence, bispectral index (BIS) values, and electromyographic monitoring characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      An interim analysis after 110 patients showed mean QoR-40 scores of 185 (standard deviation(SD): 11.4) (placebo), 186.1 (SD: 13.6) (IVL), and 185.1 (SD: 14.3) (TL) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.662). Mean differences were 1.1 (IVL vs placebo, 95%CI: \u22125.03, 7.15, z = 0.347) and 0.1 (TL vs placebo, 95%CI: \u22126.02, 6.23, z = 0.035). The study was stopped due to lack of effectiveness as the superiority of IVL and TL was not demonstrated. No differences were found in secondary outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Neither IVL nor TL improved the QoR from anaesthesia and did not affect electromyographic monitoring in low-risk thyroid surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_487_24","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T12:00:10Z","timestamp":1733227210000},"page":"1055-1061","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Effects of intracuff and intravenous lignocaine on recovery from anaesthesia after thyroid surgery. A single-centre randomised double-blind placebo-controlled trial (The IOLANT study)"],"prefix":"10.4103","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-9169","authenticated-orcid":false,"given":"Sergey M.","family":"Efremov","sequence":"first","affiliation":[{"name":"Anaesthesiology Department, Saint Petersburg State University Hospital, Saint-Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-253X","authenticated-orcid":false,"given":"Alexey Y.","family":"Kulikov","sequence":"additional","affiliation":[{"name":"Anaesthesiology Department, Saint Petersburg State University Hospital, Saint-Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7922-9005","authenticated-orcid":false,"given":"Valeria P.","family":"Govorushkina","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Department, Saint Petersburg State University Hospital, Saint-Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-8421","authenticated-orcid":false,"given":"Daniil D.","family":"Sidorov","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Saint Petersburg State University, Saint-Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0297-2546","authenticated-orcid":false,"given":"Alexey A.","family":"Ladutko","sequence":"additional","affiliation":[{"name":"Scientific Department, Smooth Drug Development, Wilmington, DE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-2527","authenticated-orcid":false,"given":"Oleg V.","family":"Kuleshov","sequence":"additional","affiliation":[{"name":"Anaesthesiology Department, Saint Petersburg State University Hospital, Saint-Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"issue":"Suppl 1","key":"R1-20260424","first-page":"S1","article-title":"Electrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery: International standards guideline statement","volume":"121","author":"Randolph","year":"2011","journal-title":"Laryngoscope"},{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1213\/ANE.0000000000002797","article-title":"Intravenously administered lidocaine and magnesium during thyroid surgery in female patients for better quality of recovery after anesthesia","volume":"127","author":"Kim","year":"2018","journal-title":"Anesth Analg"},{"key":"R3-20260424","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12871-019-0739-1","article-title":"Effects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery","volume":"19","author":"Hu","year":"2019","journal-title":"BMC Anesthesiol"},{"key":"R4-20260424","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/anae.15270","article-title":"The use of intravenous lidocaine for postoperative pain and recovery: International consensus statement on efficacy and safety","volume":"76","author":"Foo","year":"2021","journal-title":"Anaesthesia"},{"key":"R5-20260424","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1213\/ANE.0000000000002647","article-title":"Alkalinized lidocaine preloaded endotracheal tube cuffs reduce emergence cough after brief surgery: A prospective randomized trial","volume":"126","author":"Nath","year":"2018","journal-title":"Anesth Analg"},{"key":"R6-20260424","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0928-0987(01)00119-1","article-title":"Endotracheal tube cuffs filled with lidocaine as a drug delivery system: In vitro and in vivo investigations","volume":"13","author":"Dollo","year":"2001","journal-title":"Eur J Pharm Sci"},{"key":"R7-20260424","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/oxfordjournals.bja.a013366","article-title":"Validity and reliability of a postoperative quality of recovery score: The QoR-40","volume":"84","author":"Myles","year":"2000","journal-title":"Br J Anaesth"},{"key":"R8-20260424","doi-asserted-by":"crossref","first-page":"132","DOI":"10.21320\/1818-474X-2022-2-132-142","article-title":"Development and testing of the Russian version of postoperative quality of recovery score \u2014 the QoR-40 and its short form \u2014 QoR-15","volume":"29","author":"Nikitina","year":"2022","journal-title":"Ann Crit Care"},{"key":"R9-20260424","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4103\/1658-354X.136422","article-title":"Tracheal tube cuff inflation guided by pressure volume loop closure associated with lower postoperative cuff-related complications: Prospective, randomized clinical trial","volume":"8","author":"Almarakbi","year":"2014","journal-title":"Saudi J Anaesth"},{"key":"R10-20260424","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00268-016-3842-1","article-title":"The effects of intravenous lidocaine infusions on the quality of recovery and chronic pain after robotic thyroidectomy: A randomized, double-blinded, controlled study","volume":"41","author":"Choi","year":"2017","journal-title":"World J Surg"},{"key":"R11-20260424","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jclinane.2015.09.003","article-title":"Effect of laryngotracheal topical anesthesia on recurrent laryngeal nerve monitoring during thyroid surgery","volume":"29","author":"Pachuski","year":"2016","journal-title":"J Clin Anesth"},{"key":"R12-20260424","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/anae.13438","article-title":"Postoperative sore throat: A systematic 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Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ija.ija_487_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:42Z","timestamp":1786647702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ija.ija_487_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ija.ija_487_24","relation":{},"ISSN":["0019-5049","0976-2817"],"issn-type":[{"value":"0019-5049","type":"print"},{"value":"0976-2817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-05-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}