{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:54Z","timestamp":1787169834077,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Lung protective ventilation (LPV) is recommended in acute respiratory distress syndrome. However, role of intraoperative LPV in elective laparotomy is controversial and it has not been evaluated in emergency laparotomy (EL). The aim of the study was to identify whether use of intraoperative LPV in EL in peritonitis patients reduces postoperative pulmonary complications (POPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      After institutional ethics committee approval and informed written consent, 98 adult patients undergoing EL for peritonitis were randomised into two groups. Patients in group 1 received LPV (tidal volume 6\u20138 ml\/kg, positive end expiratory pressure (PEEP) 6\u20138 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O and recruitment manoeuvre every 30 min) and patients in group 2 received conventional ventilation (tidal volume 10-12 ml\/kg, without PEEP\/recruitment). Primary outcome was incidence of POPC on day 7.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Data of 94 patients (n = 45 in group 1 &amp; n = 49 in group 2) were available. Baseline demographic &amp; laboratory parameters were comparable. Incidence of POPC was similar in both the groups [42.9% in group 1 vs. 53.3% in group 2; risk difference -10.4% (-30.6%, 9.6%);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.31]. Mortality during hospital stay was 26.7% patients in group 1 and 26.5% patients in group 2 [risk difference (95% CI) 0.14%, (-17.7, 18.0);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.98]. Length of hospital stay [median interquartile range (IQR) 13 (9\u201318) days in group 1 vs. 13 (8\u201321) days in group 2;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.82] and length of intensive care unit stay [median (IQR) 7 (4\u201310) days vs. 6 (3\u201312) days;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.88] were also similar in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>LPV during EL in peritonitis patients does not reduce the incidence of POPC compared to conventional ventilation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_573_21","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T06:24:57Z","timestamp":1637303097000},"page":"798-805","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Intraoperative lung protective ventilation in peritonitis patients undergoing emergency laparotomy: A randomised controlled trial"],"prefix":"10.4103","volume":"65","author":[{"given":"Apala Roy","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Maitra","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulagna","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishnan","family":"Lakshmy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalim Kumar","family":"Baidya","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and 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