{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:42Z","timestamp":1787169942955,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"\n Background and Aims:<\/jats:title>\n \n In traumatic brain injury (TBI) patients, elevated intracranial pressure leading to brain\u2013lung interactions is well described. This study aimed to find the association between the optic nerve sheath diameter (ONSD) variations and respiratory mechanics, that is, static lung compliance (Cstat), and driving pressure (DP) in TBI patients. The secondary objectives were to observe the association between ONSD and lung ultrasound score (LUS), arterial partial pressure of oxygen and fraction of inspired oxygen ratio (PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n ), and clinical pulmonary infection score (CPIS).\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n The prospective observational study, conducted at a tertiary care centre, recruited patients with moderate to severe TBI admitted to the neuro-intensive care unit within 24 h of injury. From day 1 to 5, once a day, ONSD, Cstat, DP, minute ventilation (MV), and LUS were recorded. The association between the ONSD variations and respiratory mechanics, LUS, PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n ratio, and CPIS was studied using linear mixed-effect models.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 27 patients were included. No significant association was found between ONSD and Cstat [ipsilateral ONSD: model coefficient (\u03b2) = 1.13,\n P<\/jats:italic>\n = 0.70; contralateral ONSD \u03b2 = 2.0,\n P<\/jats:italic>\n = 0.46] and driving pressure (ipsilateral ONSD: \u03b2 = 0.18,\n P<\/jats:italic>\n = 0.82; contralateral ONSD: \u03b2 = 0.29,\n P<\/jats:italic>\n = 0.7). Higher MV was observed with higher ONSD (ipsilateral ONSD: \u03b2 = 1.44,\n P<\/jats:italic>\n = 0.033; contralateral ONSD: \u03b2 = 2.23,\n P<\/jats:italic>\n = 0.001). ONSD variations were not associated with LUS, PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n , or CPIS.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Variations in ONSD did not impact the respiratory mechanics of ventilated acute TBI patients, though patients with higher ONSD were found to have higher MV.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ija.ija_686_25","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:00:25Z","timestamp":1771606825000},"page":"349-357","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Impact of optic nerve sheath diameter variations on respiratory mechanics in ventilated traumatic brain injury patients: A pilot prospective observational study"],"prefix":"10.4103","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0666-7101","authenticated-orcid":false,"given":"Divya","family":"Rana","sequence":"first","affiliation":[{"name":"Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4830-0347","authenticated-orcid":false,"given":"Rajeeb Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-7122","authenticated-orcid":false,"given":"Rohini M.","family":"Surve","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4804-5403","authenticated-orcid":false,"given":"Dhritiman","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7820-5909","authenticated-orcid":false,"given":"Roma","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"R1-20260417","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s13054-021-03778-0","article-title":"Brain\u2013lung interactions and mechanical ventilation in patients with isolated brain injury","volume":"25","author":"Ziaka","year":"2021","journal-title":"Crit Care"},{"key":"R2-20260417","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.clineuro.2012.09.001","article-title":"Increased intracranial pressure is associated with the development of acute lung injury following severe traumatic brain injury","volume":"115","author":"Lou","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"R3-20260417","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0140-6736(75)90729-1","article-title":"Pathogenesis of neurogenic pulmonary oedema","volume":"306","author":"Theodore","year":"1975","journal-title":"Lancet"},{"key":"R4-20260417","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s12028-009-9242-8","article-title":"Acute lung injury in patients with severe brain injury: A double hit model","volume":"11","author":"Mascia","year":"2009","journal-title":"Neurocrit Care"},{"key":"R5-20260417","doi-asserted-by":"crossref","first-page":"711273","DOI":"10.3389\/fphys.2021.711273","article-title":"Effects of positive end-expiratory pressure on lung recruitment, respiratory mechanics, and intracranial pressure in mechanically ventilated brain-injured patients","volume":"12","author":"Robba","year":"2021","journal-title":"Front Physiol"},{"key":"R6-20260417","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13054-022-03903-7","article-title":"Effects of positive end-expiratory pressure on lung ultrasound patterns and their correlation with intracranial pressure in mechanically ventilated brain injured patients","volume":"26","author":"Robba","year":"2022","journal-title":"Crit Care"},{"key":"R7-20260417","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/bjophthalmol-2018-312934","article-title":"Ultrasonic measurement of optic nerve sheath diameter: A non-invasive surrogate approach for dynamic, real-time evaluation of intracranial pressure","volume":"103","author":"Chen","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"R8-20260417","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.7863\/ultra.34.7.1285","article-title":"Sonography of the optic nerve sheath diameter for detection of raised intracranial pressure compared to computed tomography: A systematic review and meta-analysis","volume":"34","author":"Ohle","year":"2015","journal-title":"J Ultrasound Med"},{"key":"R9-20260417","doi-asserted-by":"crossref","DOI":"10.1007\/s12028-024-01970-y","article-title":"Fast and deep breathing in acute brain injury","author":"Wijdicks","year":"2024","journal-title":"Neurocrit Care"}],"container-title":["Indian Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ija.ija_686_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:15:19Z","timestamp":1787166919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ija.ija_686_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ija.ija_686_25","relation":{},"ISSN":["0019-5049","0976-2817"],"issn-type":[{"value":"0019-5049","type":"print"},{"value":"0976-2817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-05-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}