{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:27:02Z","timestamp":1787761622926,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Major complications of central neuraxial block (CNB) are rare and their incidence in India is not known. This information is essential for explaining risk and medico-legal concerns. The present multi-centre study in Maharashtra was conducted to provide insight into the characteristics of rare complications following this popular anaesthetic technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data were collected from 141 institutes to study the clinical profile of CNB. Incidence of complications like vertebral canal haematoma, abscess, meningitis, nerve injury, spinal cord ischaemia, fatal cardiovascular collapse, and drug errors was collected over one year. Complications were reviewed by audit committee to assess causation, severity, and outcome. \u2018Permanent\u2019 injury was defined as death or neurological symptoms persisting for more than six months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Spinal anaesthesia (SA) was the most frequently used CNB in 88.76% patients. Bupivacaine and an adjuvant were used in 92.90% and 26.06% patients, respectively. Eight major complications (four neurological and four cardiac arrests) were reported in patients receiving SA. In seven of eight instances, SA was responsible or contributory for complication. The pessimistic incidence of complications (included cases where CNB was responsible; contribution was likely, unlikely and could not be commented) was 8.69\/lakh and optimistic incidence (included cases where CNB was responsible or contribution was likely) was 7.61\/lakh. \u2018Pessimistically\u2019 and \u2018optimistically\u2019 there were three deaths including one death due to quadriplegia following epidural haematoma after SA. Five out of eight patients recovered completely (62.5%). As only eight patients had complications of different types, it was difficult to establish statistical correlation of major complications with demographic or clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study was reassuring and suggested that the incidence of major complications following CNB was low in Maharashtra.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_747_22","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T05:00:02Z","timestamp":1675918802000},"page":"S15-S28","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Major complications following central neuraxial block \u2013 A multi-centre observational study in Maharashtra (MGMM CNB Study)"],"prefix":"10.4103","volume":"67","author":[{"given":"Sadhana S.","family":"Kulkarni","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, MGM Medical College and Hospital, Aurangabad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak N.","family":"Tayade","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Anaesthesiology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha P.","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Jehangir Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran R.","family":"Bhingarde","sequence":"additional","affiliation":[{"name":"Senior Consultant Anaesthesiologist, Kolhapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramanand N.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Tata Memorial Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savani S.","family":"Futane","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Maharashtra Post Graduate Institute of Medical Education and Research, Nashik, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasanti P.","family":"Kelkar","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Anaesthesiology, MGM Medical College and Hospital, Aurangabad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukund K.","family":"Parchandekar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Govt. 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