{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:08Z","timestamp":1787071448063,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>\n                      Postoperative sore throat (POST) is an undesirable event reported in up to 62% of patients receiving general anaesthesia (GA). The incidence of POST following GA using a supraglottic airway device (SAD) is approximately 50%, with symptoms persisting up to 48 h. We examined the role of preoperative lozenges containing amylmetacresol and dichlorobenzyl alcohol (AMC\/DCBA) with lignocaine (Strepsils\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Max Plus) in reducing the incidence and intensity of POST following GA using SAD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a prospective, double-blinded, randomised, placebo-controlled trial involving 88 adults receiving GA for elective surgery using SAD not exceeding 2 h. Patients received either Strepsils Max Plus (Strepsils-LA group) or a placebo before induction of GA. The incidence and intensity of sore throat, dysphagia and dysphonia was measured using the Verbal Rating Scale at 30 min (early) and at 24 h (late) after removal of SAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Overall POST incidence was lower in the Strepsils-LA group (27.7% versus 56.8%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007). Patients in the Strepsils-LA group reported a significantly lower incidence of early POST (14.9% versus 37.8%,\n                      <jats:italic toggle=\"yes\">P =<\/jats:italic>\n                      0.016) with a lower mean \u00b1 standard deviation intensity score (0.17 \u00b1 0.43 versus 0.49 \u00b1 0.69,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016). Although the overall incidence of dysphagia was lower (23.4% versus 48.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016), more patients experienced dysphonia in the Strepsils-LA group. AMC\/DCBA with lignocaine lozenges showed a relative risk reduction of 50% and a number needed to treat of 4 in reducing POST.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AMC\/DCBA with lignocaine lozenges administered before GA using SAD is a simple and safe method to reduce the incidence and severity of POST.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ija.ija_809_21","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T11:23:45Z","timestamp":1658402625000},"page":"523-529","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative amylmetacresol and dichlorobenzyl alcohol with lignocaine lozenge reduces postoperative sore throat following general anaesthesia using supraglottic airway devices: A double-blinded, randomised, placebo-controlled trial"],"prefix":"10.4103","volume":"66","author":[{"given":"Sebastian","family":"Sundaraj","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Hospital Tengku Ampuan Afzan, Pahang, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina Ismiarti","family":"Shariffuddin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook Hui","family":"Chaw","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Aizat Wan","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Wei Shan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shairil Rahayu","family":"Ruslan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/anae.13438","article-title":"Postoperative sore throat:A systematic 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