{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:28:13Z","timestamp":1787228893803,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cancer patients are at increased risk of coronary artery disease. Vascular dysfunction is first reflected as arterial stiffness, which can be assessed by pulse wave velocity (PWV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aims to appraise whether PWV is a clinical indicator of arterial stiffness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A case-control observational study was undertaken in a tertiary teaching hospital among 589 participants, including 197 cancer patients undergoing treatment and 392 age-matched controls. Arterial stiffness and hemodynamic parameters were measured noninvasively using the Diabetes Risk Profiler system based on PeriScope\n                      <jats:sup>\u00ae<\/jats:sup>\n                      technology. Statistical analysis included comparison of means, correlation analysis, and multiple linear regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Cancer patients showed significantly higher heart rate, systolic and diastolic blood pressure, pulse pressure, brachial-ankle PWV, carotid-femoral PWV, aortic pulse pressure, augmentation pressure, and augmentation index than controls, while ankle-brachial index was significantly lower (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In cancer patients, PWV showed strong positive correlations with age and systolic blood pressure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Cancer patients undergoing treatment have markedly increased arterial stiffness and altered vascular function compared with controls. PWV may be a useful, simple, and noninvasive marker for early cardiovascular risk assessment in cardio-oncology practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijabmr.ijabmr_119_26","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:00:37Z","timestamp":1787166037000},"page":"192-196","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Arterial Stiffness Assessed By Pulse Wave Velocity as a Predictor of Cardiovascular Risk Factors in Cancer Patients"],"prefix":"10.4103","volume":"16","author":[{"given":"D. Dinakar","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Physiology, SDUMC, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagadamba","family":"Aswathappa","sequence":"additional","affiliation":[{"name":"Department of Physiology, SDUMC, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay K.","family":"Kattepur","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, SDUMC, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"R1-20260820","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1093\/eurheartj\/ehz766","article-title":"A population-based study of cardiovascular disease mortality risk in US cancer patients","volume":"40","author":"Sturgeon","year":"2019","journal-title":"Eur Heart J"},{"key":"R2-20260820","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur Heart J"},{"key":"R3-20260820","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.annonc.2019.10.023","article-title":"Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations","volume":"31","author":"Curigliano","year":"2020","journal-title":"Ann Oncol"},{"key":"R4-20260820","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.020406","article-title":"Shared risk factors in cardiovascular disease and cancer","volume":"133","author":"Koene","year":"2016","journal-title":"Circulation"},{"key":"R5-20260820","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/CIRCULATIONAHA.115.018347","article-title":"Vascular toxicities of cancer therapies: The old and the new--An evolving avenue","volume":"133","author":"Herrmann","year":"2016","journal-title":"Circulation"},{"key":"R6-20260820","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3390\/jcm9072080","article-title":"Accuracy of pulse wave velocity predicting cardiovascular and all-cause mortality. A systematic review and meta-analysis","volume":"9","author":"Sequ\u00ed-Dom\u00ednguez","year":"2020","journal-title":"J Clin Med"},{"key":"R7-20260820","doi-asserted-by":"crossref","first-page":"266","DOI":"10.31083\/j.rcm2507266","article-title":"Pulse wave velocity: Methodology, clinical applications, and interplay with heart rate variability","volume":"25","author":"Pilz","year":"2024","journal-title":"Rev Cardiovasc Med"},{"key":"R8-20260820","doi-asserted-by":"crossref","first-page":"e015598","DOI":"10.1161\/JAHA.119.015598","article-title":"Anticancer therapy-related increases in arterial stiffness: A systematic review and meta-analysis","volume":"9","author":"Parr","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"R9-20260820","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3390\/ph17091115","article-title":"The impact of chemotherapy on arterial stiffness and ventricular-arterial coupling in women with breast cancer","volume":"17","author":"Kadoglou","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"R10-20260820","doi-asserted-by":"crossref","first-page":"107195","DOI":"10.1016\/j.vph.2023.107195","article-title":"Prolonged impact of anti-cancer therapy on endothelial function and arterial stiffness in breast cancer patients","volume":"152","author":"Anastasiou","year":"2023","journal-title":"Vascul Pharmacol"},{"key":"R11-20260820","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2147\/CMAR.S223032","article-title":"Cardiotoxic profile and arterial stiffness of adjuvant chemotherapy for colorectal cancer","volume":"12","author":"Visvikis","year":"2020","journal-title":"Cancer Manag Res"},{"key":"R12-20260820","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s12012-024-09841-w","article-title":"Arterial stiffness may predict subsequent cancer therapy-related cardiac dysfunction in breast cancer patients","volume":"24","author":"\u015eahin","year":"2024","journal-title":"Cardiovasc Toxicol"},{"key":"R13-20260820","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/HYPERTENSIONAHA.122.17947","article-title":"Established and emerging cancer therapies and cardiovascular system: Focus on hypertension-mechanisms and mitigation","volume":"80","author":"Butel-Simoes","year":"2023","journal-title":"Hypertension"}],"container-title":["International Journal of Applied &amp; Basic Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_119_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:00:58Z","timestamp":1787227258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_119_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijabmr.ijabmr_119_26","relation":{},"ISSN":["2229-516X","2248-9606"],"issn-type":[{"value":"2229-516X","type":"print"},{"value":"2248-9606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}