{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:15Z","timestamp":1787775675001,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Rheumatoid arthritis (RA) is a systemic, chronic, and inflammatory autoimmune disease with a strong genetic component.\n                      <jats:italic toggle=\"yes\">ARL15<\/jats:italic>\n                      gene variant rs255758 has been reported as a candidate for RA susceptibility. A replication study was performed on this variant by taking 188 RA cases and 310 healthy non-RA controls from northwest India in a case\u2013control association study design.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>DNA isolated from collected blood samples was analyzed by genotyping of the variant on real-time polymerase chain reaction using TaqMan Allele Discrimination Assay and statistically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The variant was found to follow Hardy\u2013Weinberg Equilibrium (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.079) in the control group. The variant was significantly associated with RA susceptibility in the present studied population cohort (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.024) with\n                      <jats:italic toggle=\"yes\">C<\/jats:italic>\n                      as a risk allele and increased risk in the recessive model (\n                      <jats:italic toggle=\"yes\">CC<\/jats:italic>\n                      vs.\n                      <jats:italic toggle=\"yes\">CA<\/jats:italic>\n                      +\n                      <jats:italic toggle=\"yes\">AA<\/jats:italic>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The present study corroborates the earlier findings on the role of\n                      <jats:italic toggle=\"yes\">ARL15<\/jats:italic>\n                      gene variant rs255758 in RA and further contributes to its genetic etiology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijabmr.ijabmr_156_24","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T14:00:56Z","timestamp":1736431256000},"page":"38-42","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["ARL15 Gene Variant rs255758 Provides Susceptibility to Rheumatoid Arthritis in Northwest Indian Population"],"prefix":"10.4103","volume":"15","author":[{"given":"Inder Mohan Singh","family":"Sandhu","sequence":"first","affiliation":[{"name":"Department of Genetics, Sri Guru Ram Das Institute of Medical Sciences and Research, SGRDUHS, Amritsar, Punjab, 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