{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:00Z","timestamp":1786649340162,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Vitamin D (VD) deficiency has become a global epidemic in the past 2 decades. Cardiac troponin is a specific biomarker for detecting myocardial injury, particularly in the context of myocardial infarction (MI), where elevated levels are indicative of myocardial necrosis. This study aimed to investigate the relationship between VD levels and troponin values in patients admitted to the Intensive Care Unit under suspicion of acute coronary syndrome, including comparisons with patients ultimately not diagnosed with ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This cross-sectional study included a group of 69 patients who were hospitalized in the Intensive Care Unit of the Hospital under suspicion of acute coronary syndrome. The control consisted of patients without ACS. The content of VD-(25[OH]D) in blood plasma was measured by enzyme-linked immunosorbent assay during June\u2013August 2024. Blood samples were taken in tubes with ethylenediaminetetraacetic acid anticoagulant. The tubes without anticoagulant were used for collecting blood for VD, fibrinogen, D-dimer, and lipid parameter measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A statistically significant difference in total cholesterol levels was observed between patients with angina pectoris and those with MI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Pearson correlation analysis also demonstrated a moderate negative correlation between VD levels and troponin values in patients diagnosed with MI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05), indicating that lower VD concentrations may be associated with greater myocardial injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Based on the data obtained, the medical community is inclined to believe that correction of VD deficiency has great prognostic significance. Further clinical and experimental studies are needed to study in more detail the mechanisms of the negative effects of VD deficiency on the cardiovascular system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijabmr.ijabmr_161_25","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T19:00:17Z","timestamp":1766170817000},"page":"251-257","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between Vitamin D Levels and Troponin in Patients Suspected of Acute Coronary Syndrome: A Cross-sectional Intensive Care Unit Study"],"prefix":"10.4103","volume":"15","author":[{"given":"Ekrema","family":"Mujari\u0107","sequence":"first","affiliation":[{"name":"Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majda","family":"Ka\u010damakovi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Center - Clinic for Lung Diseases and Tuberculosis \"Podhrastovi\", Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Crnica","sequence":"additional","affiliation":[{"name":"University Clinical Center - Clinic for Lung Diseases and Tuberculosis \"Podhrastovi\", Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajrudin","family":"Spahovi\u0107","sequence":"additional","affiliation":[{"name":"Urology Clinic, Clinical Center University of Sarajevo, Bolni\u010dka 25, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferid","family":"Krupi\u0107","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Biosciences, COMSATS University Islamabad (CUI), Park Road, Chak Shahzad, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muamer","family":"Dervi\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Center - Clinic for Lung Diseases and Tuberculosis \"Podhrastovi\", Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emina","family":"Dervi\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4065\/81.3.353","article-title":"High prevalence of Vitamin D inadequacy and implications for health","volume":"81","author":"Holick","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"R2-20260420","first-page":"359","article-title":"High prevalence of low dietary calcium and low Vitamin D status in healthy south Indians","volume":"13","author":"Harinarayan","year":"2004","journal-title":"Asia Pac J Clin Nutr"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0140-6736(05)78933-9","article-title":"Redefining Vitamin D insufficiency","volume":"351","author":"Malabanan","year":"1998","journal-title":"Lancet"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s001980050030","article-title":"Prevalence of Vitamin D insufficiency in an adult normal population","volume":"7","author":"Chapuy","year":"1997","journal-title":"Osteoporos Int"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF02555253","article-title":"Demonstration of 1,25(OH)2 Vitamin D3 receptors and actions in vascular smooth muscle cells in vitro","volume":"41","author":"Merke","year":"1987","journal-title":"Calcif Tissue Int"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1172\/JCI114097","article-title":"Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries","volume":"83","author":"Merke","year":"1989","journal-title":"J Clin Invest"},{"key":"R7-20260420","first-page":"H1751","article-title":"1,25\u2013Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy","volume":"272","author":"O\u2019Connell","year":"1997","journal-title":"Am J Physiol"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"19916","DOI":"10.1016\/S0021-9258(17)45460-3","article-title":"Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct","volume":"265","author":"Sigmund","year":"1990","journal-title":"J Biol Chem"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI0215219","article-title":"1,25\u2013Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system","volume":"110","author":"Li","year":"2002","journal-title":"J Clin Invest"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.3390\/ijms21186483","article-title":"Vitamin D and cardiovascular disease, with emphasis on hypertension, atherosclerosis, and heart failure","volume":"21","author":"Latic","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1161\/CIRCULATIONAHA.113.002654","article-title":"Role of Vitamin D in atherosclerosis","volume":"128","author":"Kassi","year":"2013","journal-title":"Circulation"},{"key":"R12-20260420","first-page":"E1108","article-title":"1,25(OH)2D3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes","volume":"268","author":"Wu","year":"1995","journal-title":"Am J Physiol"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"E125","DOI":"10.1152\/ajpendo.00224.2004","article-title":"Cardiac hypertrophy in Vitamin D receptor knockout mice: Role of the systemic and cardiac renin-angiotensin systems","volume":"288","author":"Xiang","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R14-20260420","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"R16-20260420","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jacc.2008.08.050","article-title":"Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?","volume":"52","author":"Lee","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"R17-20260420","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1056\/NEJM199610313351802","article-title":"Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes","volume":"335","author":"Antman","year":"1996","journal-title":"N Engl J Med"},{"key":"R18-20260420","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1001\/jama.2010.1708","article-title":"Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults","volume":"304","author":"deFilippi","year":"2010","journal-title":"JAMA"},{"key":"R19-20260420","doi-asserted-by":"crossref","first-page":"e4322","DOI":"10.1371\/journal.pone.0004322","article-title":"Systemic correlates of angiographic coronary artery disease","volume":"4","author":"Nunes","year":"2009","journal-title":"PLoS One"},{"key":"R20-20260420","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1373\/clinchem.2006.077180","article-title":"Expressing the modification of diet in renal disease study equation for estimating glomerular filtration rate with standardized serum creatinine values","volume":"53","author":"Levey","year":"2007","journal-title":"Clin Chem"},{"key":"R21-20260420","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1067\/mhj.2001.111767","article-title":"Evidence of cardiac myolysis in severe nonischemic heart failure and the potential role of increased wall strain","volume":"141","author":"Logeart","year":"2001","journal-title":"Am Heart J"},{"key":"R22-20260420","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00424-007-0354-8","article-title":"Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation","volume":"455","author":"Hessel","year":"2008","journal-title":"Pflugers Arch"},{"key":"R23-20260420","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"R24-20260420","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1542-4758.2011.00630.x","article-title":"FGF-23 is associated with cardiac troponin T and mortality in hemodialysis patients","volume":"16","author":"Holden","year":"2012","journal-title":"Hemodial Int"},{"key":"R25-20260420","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1055\/s-0028-1093390","article-title":"Vitamin D and ischaemic heart disease","volume":"10","author":"Lund","year":"1978","journal-title":"Horm Metab Res"},{"key":"R26-20260420","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/ije\/19.3.559","article-title":"Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: A community-based study","volume":"19","author":"Scragg","year":"1990","journal-title":"Int J Epidemiol"},{"key":"R27-20260420","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.amjcard.2011.01.048","article-title":"Prevalence of Vitamin D deficiency in patients with acute myocardial infarction","volume":"107","author":"Lee","year":"2011","journal-title":"Am J Cardiol"},{"key":"R28-20260420","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1161\/ATVBAHA.112.248039","article-title":"25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: Population-based study and meta-analyses of 18 and 17 studies","volume":"32","author":"Br\u00f8ndum-Jacobsen","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R29-20260420","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s40292-018-0295-7","article-title":"Association of Vitamin D deficiency with chronic stable angina: A case control study","volume":"26","author":"Raslan","year":"2019","journal-title":"High Blood Press Cardiovasc Prev"},{"key":"R30-20260420","doi-asserted-by":"crossref","first-page":"e19544","DOI":"10.1097\/MD.0000000000019544","article-title":"Association of Vitamin D status with coronary artery disease in postmenopausal women","volume":"99","author":"Xu","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"R31-20260420","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.18410\/jebmh\/2021\/514","article-title":"Prevalence of low circulatory vitamin D levels in patients with acute myocardial infarction \u2013 A cross sectional study from a tertiary care centre in Kozhikode, Kerala","volume":"8","author":"Kunnath","year":"2021","journal-title":"J Evid Based Med Healthc"},{"key":"R32-20260420","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1001\/archinte.168.11.1174","article-title":"25-hydroxyvitamin D and risk of myocardial infarction in men: A prospective study","volume":"168","author":"Giovannucci","year":"2008","journal-title":"Arch Intern Med"},{"key":"R33-20260420","doi-asserted-by":"crossref","first-page":"21058","DOI":"10.1038\/s41598-023-47872-5","article-title":"Association between serum Vitamin D levels and lipid profiles: A cross-sectional analysis","volume":"13","author":"Gholamzad","year":"2023","journal-title":"Sci Rep"},{"key":"R34-20260420","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3390\/metabo9070125","article-title":"Relationship between Vitamin D level and lipid profile in non-obese children","volume":"9","author":"Kim","year":"2019","journal-title":"Metabolites"},{"key":"R35-20260420","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/jbcr\/irz029","article-title":"Mitochondrial DNA-induced inflammatory responses and lung injury in thermal injury murine model: Protective Effect of cyclosporine-A","volume":"40","author":"Liu","year":"2019","journal-title":"J Burn Care Res"},{"key":"R36-20260420","doi-asserted-by":"crossref","first-page":"7682","DOI":"10.12659\/MSM.909909","article-title":"Attenuation of lipopolysaccharide-induced acute lung injury by cyclosporine-a via suppression of mitochondrial DNA","volume":"24","author":"Xiao","year":"2018","journal-title":"Med Sci Monit"},{"key":"R37-20260420","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING-induced inflammation","volume":"561","author":"Sliter","year":"2018","journal-title":"Nature"},{"key":"R38-20260420","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/ndt\/gfr695","article-title":"Apoptotic cell-free DNA promotes inflammation in haemodialysis patients","volume":"27","author":"Atamaniuk","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"R39-20260420","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3389\/fphys.2018.01543","article-title":"Why F-ATP synthase remains a strong candidate as the mitochondrial permeability transition pore","volume":"9","author":"Bernardi","year":"2018","journal-title":"Front Physiol"},{"key":"R40-20260420","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.abb.2007.03.034","article-title":"Selective degradation of mitochondria by mitophagy","volume":"462","author":"Kim","year":"2007","journal-title":"Arch Biochem Biophys"}],"container-title":["International Journal of Applied &amp; Basic Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_161_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:52:40Z","timestamp":1786647160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_161_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijabmr.ijabmr_161_25","relation":{},"ISSN":["2229-516X","2248-9606"],"issn-type":[{"value":"2229-516X","type":"print"},{"value":"2248-9606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}