{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:51Z","timestamp":1786649811681,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Background:<\/jats:title>\n Pregabalin is being used as preemptive analgesic for better postoperative pain management. This present study was aimed at comparing effectiveness and safety of 75 mg and 150 mg of oral pregabalin given as premedication 1 h before the surgery.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n This was prospective, randomized, and double-blinded placebo controlled study in which 90 patients were enrolled and randomized into three groups of 30 patients each. Groups P75 (given 75 mg pregabalin), P150 (given 150 mg pregabalin) and C (given placebo drug). Postoperative pain and sedation assessment were done. Adverse effects such as somnolence, dizziness, nausea, and vomiting were noted.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Pain was lowest in P150 group than P75 and control group at 2 h. The duration of analgesia was highest in the P150 group followed by the P75 group with the control group showing the shortest duration. A significant difference was observed in total tramadol consumption (\n P<\/jats:italic>\n < 0.001) in three groups. Sedation scores were the highest in P150 followed by P75 and C (\n P<\/jats:italic>\n < 0.001) during the 1\n st<\/jats:sup>\n h. Somnolence was the highest in P150 group which was statistically significant. Difference in other side effects such as dizziness, nausea, vomiting, headache, and dryness of mouth was not statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Pregabalin is a safe drug and has good analgesic effect. Although the analgesic effectiveness of higher dose, i.e., 150 mg was better, adverse effect in terms of sedation was more. Hence, we suggest pregabalin 75 mg to be used preoperatively as it has demonstrated to have good analgesic effectiveness.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijabmr.ijabmr_179_25","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T19:00:23Z","timestamp":1766170823000},"page":"245-250","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and Safety of 75 mg and 150 mg Pregabalin for Postoperative Analgesia in Breast Cancer Surgery: A Randomized Double-Blinded Trial"],"prefix":"10.4103","volume":"15","author":[{"given":"M.","family":"Sashank","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Asian Institute of Medical Sciences, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, DMC and Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/pm\/pnw172","article-title":"An evidence-based review of the efficacy of perioperative analgesic techniques for breast cancer-related surgery","volume":"18","author":"Cheng","year":"2017","journal-title":"Pain Med"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"641508","DOI":"10.1155\/2015\/641508","article-title":"Can acute pain treatment reduce postsurgical comorbidity after breast cancer surgery? A literature review","volume":"2015","author":"Amaya","year":"2015","journal-title":"Biomed Res Int"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1213\/01.ane.0000261517.27532.80","article-title":"Do surgical patients benefit from perioperative gabapentin\/pregabalin? A systematic review of efficacy and safety","volume":"104","author":"Tiippana","year":"2007","journal-title":"Anesth Analg"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4097\/kjae.2017.70.4.434","article-title":"Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy","volume":"70","author":"Eidy","year":"2017","journal-title":"Korean J Anesthesiol"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1399-6576.2010.02374.x","article-title":"Pregabalin reduces post-operative pain after mastectomy: A double-blind, randomized, placebo-controlled study","volume":"55","author":"Kim","year":"2011","journal-title":"Acta Anaesthesiol Scand"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1213\/01.ane.0000287643.13410.5e","article-title":"Pregabalin: Its pharmacology and use in pain management","volume":"105","author":"Gajraj","year":"2007","journal-title":"Anesth Analg"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"e6129","DOI":"10.1097\/MD.0000000000006129","article-title":"Preoperative use of pregabalin for acute pain in spine surgery: A meta-analysis of randomized controlled trials","volume":"96","author":"Jiang","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/0970-9185.83672","article-title":"Pregabalin in acute and chronic pain","volume":"27","author":"Baidya","year":"2011","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pain.2007.04.002","article-title":"A randomized controlled trial of perioperative administration of pregabalin for pain after laparoscopic hysterectomy","volume":"134","author":"Jokela","year":"2008","journal-title":"Pain"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jclinane.2017.01.015","article-title":"Dose ranging effects of pregabalin on pain in patients undergoing laparoscopic hysterectomy: A randomized, double blinded, placebo controlled, clinical trial","volume":"38","author":"Asgari","year":"2017","journal-title":"J Clin Anesth"},{"key":"R11-20260420","first-page":"125","article-title":"Comparison of two preoperative doses of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy","volume":"6","author":"Pratibha","year":"2021","journal-title":"J Cell Mol Anesth"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4103\/joacp.JOACP_440_19","article-title":"Premedication with pregabalin 150 mg versus 300 mg for postoperative pain relief after laparoscopic cholecystectomy","volume":"36","author":"Singh","year":"2020","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4103\/0259-1162.186862","article-title":"Effect of pregabalin premedication on the requirement of anesthetic and analgesic drugs in laparoscopic cholecystectomy: Randomized comparison of two doses","volume":"11","author":"Gupta","year":"2017","journal-title":"Anesth Essays Res"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/bja\/aen244","article-title":"Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy","volume":"101","author":"Agarwal","year":"2008","journal-title":"Br J Anaesth"},{"key":"R16-20260420","first-page":"e27783","article-title":"Reduction of acute postoperative pain with pre-emptive pregabalin following laparoscopic cholecystectomy","volume":"14","author":"Najam","year":"2022","journal-title":"Cureus"},{"key":"R17-20260420","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/abr.abr_222_22","article-title":"Comparison of the effect of preoperative oral tizanidine and pregabalin on shoulder pain in laparoscopic cholecystectomy under general anesthesia","volume":"12","author":"Sane","year":"2023","journal-title":"Adv Biomed Res"},{"key":"R18-20260420","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.2147\/JPR.S170810","article-title":"Effects of a single dose of preoperative pregabalin and gabapentin for acute postoperative pain: A network meta-analysis of randomized controlled trials","volume":"11","author":"Hu","year":"2018","journal-title":"J Pain Res"},{"key":"R19-20260420","first-page":"e46719","article-title":"Comparison of the efficacy of pregabalin and gabapentin for preemptive analgesia in laparoscopic cholecystectomy patients: A randomised double-blind study","volume":"15","author":"Kaur","year":"2023","journal-title":"Cureus"},{"key":"R20-20260420","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.bjps.2017.05.054","article-title":"Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials","volume":"70","author":"Rai","year":"2017","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"R21-20260420","first-page":"e70142","article-title":"Evaluation of oral pregabalin as a preemptive adjuvant for postoperative pain in patients undergoing coronary artery bypass grafting with general anesthesia and high thoracic epidural: A randomized controlled study","volume":"16","author":"Sharma","year":"2024","journal-title":"Cureus"},{"key":"R22-20260420","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5468\/ogs.21345","article-title":"Preemptive pregabalin for postoperative analgesia during minimally invasive hysterectomy: A systematic review and meta-analysis of randomized controlled trials","volume":"65","author":"Abu-Zaid","year":"2022","journal-title":"Obstet Gynecol Sci"},{"key":"R23-20260420","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/AJP.0000000000000883","article-title":"Perioperative pregabalin for preventive analgesia in breast cancer surgery: A meta-analysis of randomized controlled trials","volume":"36","author":"Chang","year":"2020","journal-title":"Clin J Pain"}],"container-title":["International Journal of Applied & Basic Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_179_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:41Z","timestamp":1786647521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_179_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijabmr.ijabmr_179_25","relation":{},"ISSN":["2229-516X","2248-9606"],"issn-type":[{"value":"2229-516X","type":"print"},{"value":"2248-9606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}