{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:18:25Z","timestamp":1793215105997,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Acute pancreatitis (AP) scores need a battery of tests that are not helpful at an early stage. Can a single test predict Complicated Acute Pancreatitis (CAP) which includes moderate and severe AP, local complications, and need for intensive care unit (ICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>30 patients of AP. D-dimer, C-reactive protein levels done within 3 days of AP onset. APACHE II, Ranson\u2019s score, CT severity index were done. Inhospital disease course for development of organ failure and need for ICU care was followed daily.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      D-dimer in CAP was 2732 ng\/L (MAP 567 ng\/L), in abnormal computed tomography (CT) was 1916 ng\/L (normal CT 363 ng\/L), and in organ failure was 4776 ng\/L (776.5 ng\/L absent organ failure). D-dimer increases as the severity of organ failure increases (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). D-dimer in ICU patients was significantly elevated (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.021). D-dimer correlates with APACHE II score well, with an increase in predictive mortality rate (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01). On receiver operator characteristics, D-dimer &gt;933.5 ng\/L predicts CAP, &gt;827.5 ng\/L predicts positive CT findings (local complications), and &gt;1060.5 ng\/L predicts the development of organ failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Coagulopathy and microthrombi play a significant role in early pathogenesis. D-dimer test acts at the level of this core pathogenesis, even before the complications set in. D-dimer within 72 h of AP correlates well with the CT findings after 72 h. This is the first study that correlates D-dimer levels with CT scores, ICU requirement. D-dimer can guide primary care physicians in selecting AP patients for referral to a higher center in a resource-limited setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijabmr.ijabmr_483_23","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T15:05:42Z","timestamp":1716563142000},"page":"101-107","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["D-dimer as a Marker of Severity and Prognosis in Acute Pancreatitis"],"prefix":"10.4103","volume":"14","author":[{"given":"Mario Victor","family":"Newton","sequence":"first","affiliation":[{"name":"Department of General Surgery, St. John\u2019s Medical College Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"R1-20260505","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12876-019-0989-x","article-title":"Serum D-dimer levels at admission for prediction of outcomes in acute pancreatitis","volume":"19","author":"Wan","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"R2-20260505","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1056\/NEJMcp054958","article-title":"Clinical practice. 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