{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:38Z","timestamp":1786649738690,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Acute appendicitis is a common surgical emergency. While clinical diagnosis is generally effective, it is not perfect, potentially leading to negative appendectomies or delayed treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study investigated the histopathological patterns of appendectomy specimens in King Khalid Hospital, Hail Province, Saudi Arabia, correlating them with preoperative clinical diagnoses to assess diagnostic accuracy and guide optimal management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 198 patients who underwent appendectomies between August 2023 and July 2024. Resected appendix specimens underwent histopathological examination and were categorized as inflamed, malignant, or benign. Clinical data and histopathological findings were compared using statistical analyses, including Fisher\u2019s exact test, to assess diagnostic accuracy and explore potential associations between patient demographics, appendicitis severity, and clinical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study cohort consisted predominantly of young males (78.8%, mean age: 26 \u00b1 9.2 years), with no pediatric cases included. The most common histopathological finding was an inflamed appendix (99.5%), with acute inflammation being most prevalent (86.9%). Perforation (10.1%) and gangrenous changes (2.5%) were also observed. A rare case of negative appendectomy (0.5%) was attributed to a perforated Meckel\u2019s diverticulum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrates a high preoperative diagnostic accuracy for acute appendicitis. However, the occurrence of negative appendectomies and complicated cases, particularly in young adult males, highlights the need for continuous vigilance and refinement of diagnostic approaches. Further research exploring age- and sex-specific risk factors for complicated appendicitis is crucial to optimizing patient management strategies and minimizing unnecessary surgical interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijabmr.ijabmr_529_24","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T16:27:00Z","timestamp":1744043220000},"page":"85-90","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["High Diagnostic Accuracy but Persistent Risk of Complicated Appendicitis: A Retrospective Analysis from Hail Province, Saudi Arabia"],"prefix":"10.4103","volume":"15","author":[{"given":"Alfatih Mohamed Ahmed","family":"Aljanib","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Hail, Hail, Saudi Arabia"},{"name":"Department of Surgery, Faculty of Medicine, Alneelain University, Khartoum, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal Fawaz","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Hail, Hail, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad Maiyah","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Hail, Hail, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Ahmed","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, King Khalid Hospital, Hail, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bandar","family":"Alsaif","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, King Khalid Hospital, Hail, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold C.","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Health, Idaho State University, Meridian, ID, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz Bin Ali","family":"Alshammari","sequence":"additional","affiliation":[{"name":"General Administration of Health Service, Northern Armed Forces Hospital, Hafr Al Baten, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal","family":"Alharazi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Applied Medical Science, University of Hail, Hail, Saudi Arabia"},{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Taiz University, Taiz, Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"R1-20250410","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00000658-198305000-00001","article-title":"Presidential address:A history of appendicitis. With anecdotes illustrating its importance","volume":"197","author":"Williams","year":"1983","journal-title":"Ann Surg"},{"key":"R2-20250410","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.18203\/2349-2902.isj20162211","article-title":"Clinical correlates of positive and negative cases of appendicitis","volume":"3","author":"Irfan","year":"2016","journal-title":"Int Surg J"},{"key":"R3-20250410","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13017-020-00306-3","article-title":"Diagnosis and treatment of acute appendicitis:2020 update of the WSES Jerusalem guidelines","volume":"15","author":"Di Saverio","year":"2020","journal-title":"World J Emerg Surg"},{"key":"R4-20250410","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.18203\/2349-2902.isj20192078","article-title":"Clinico-pathological and etiological evaluation of acute appendicitis and assessment of significance of laboratory and ultrasonography examination as an ancillary aid to clinical diagnosis","volume":"6","author":"Paul","year":"2019","journal-title":"Int Surg J"},{"key":"R6-20250410","first-page":"1145","article-title":"What is positive appendicitis?A new answer to an old question. Clinical, macroscopical and microscopical findings in 200 consecutive appendectomies","volume":"50","author":"Hussain","year":"2009","journal-title":"Singapore Med J"},{"key":"R7-20250410","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3390\/jcm10071466","article-title":"Appendectomy and non-typhoidal salmonella infection:A population-based matched cohort study","volume":"10","author":"Wu","year":"2021","journal-title":"J Clin Med"},{"key":"R8-20250410","doi-asserted-by":"crossref","first-page":"661752","DOI":"10.3389\/fmed.2021.661752","article-title":"Risk of inflammatory bowel disease following appendectomy in adulthood","volume":"8","author":"Chung","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"R9-20250410","first-page":"11","article-title":"Diagnosis of acute appendicitis by modified Alvarado score versus ultrasound based on histopathological findings:A comparative study","volume":"29","author":"Ahmed","year":"2023","journal-title":"MJOTU"},{"key":"R10-20250410","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1055\/s-0044-1779602","article-title":"Retrospective study of patients submitted to appendectomy in a tertiary hospital:Is there a difference between the public and supplementary health system?","volume":"44","author":"Corr\u00eaa Neto","year":"2024","journal-title":"J Coloproctol"},{"key":"R11-20250410","first-page":"1","article-title":"Effects of appendectomy on the onset and course of ulcerative colitis in Chinese patients","volume":"2018","author":"Chen","year":"2018","journal-title":"Gastroenterol Res Pract"},{"key":"R12-20250410","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4103\/ejs.ejs_98_23","article-title":"Comparison between laparoscopic versus open appendectomy in morbid obese patients","volume":"42","author":"Galal","year":"2023","journal-title":"Egypt J Surg"},{"key":"R13-20250410","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1016\/j.jamcollsurg.2020.08.344","article-title":"Management of Appendicitis during Pregnancy","volume":"231","author":"Droullard","year":"2020","journal-title":"J Am Coll Surg"},{"key":"R14-20250410","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/jamasurg.2023.0284","article-title":"Outcomes of nonoperative versus operative management of acute appendicitis in older adults in the US","volume":"158","author":"Meier","year":"2023","journal-title":"JAMA Surg"},{"key":"R15-20250410","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.18203\/2349-2902.isj20183446","article-title":"A study of correlation between clinical, radiological and pathological diagnosis of appendicitis:A retrospective analytic study","volume":"5","author":"Prabhu","year":"2018","journal-title":"Int Surg J"},{"key":"R16-20250410","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/iwj.13347","article-title":"Comparison of laparoscopic and open appendectomy on wound infection and healing in complicated appendicitis","volume":"17","author":"G\u00fcler","year":"2020","journal-title":"Int Wound J"},{"key":"R17-20250410","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.amsu.2019.10.013","article-title":"Accuracy of neutrophil lymphocyte ratio for diagnosis of acute appendicitis in children:A diagnostic study","volume":"48","author":"Prasetya","year":"2019","journal-title":"Ann Med Surg (Lond)"},{"key":"R18-20250410","doi-asserted-by":"crossref","first-page":"11386","DOI":"10.53730\/ijhs.v6nS6.13158","article-title":"A comparative study of clinical, radiological and operative findings in acute appendicitis","volume":"6","author":"Niranjana","year":"2022","journal-title":"Int J Health Sci"},{"key":"R19-20250410","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/jamasurg.2019.6028","article-title":"Quality of life and patient satisfaction at 7-year follow-up of antibiotic therapy versus appendectomy for uncomplicated acute appendicitis:A secondary analysis of a randomized clinical trial","volume":"155","author":"Sippola","year":"2020","journal-title":"JAMA Surg"},{"key":"R20-20250410","doi-asserted-by":"crossref","first-page":"e0260991","DOI":"10.1371\/journal.pone.0260991","article-title":"Association of treatments for acute appendicitis with pregnancy outcomes in the United States from 2000 to 2016:Results from a multi-level analysis","volume":"16","author":"Yang","year":"2021","journal-title":"PLoS One"},{"key":"R21-20250410","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2188\/jea.JE20090011","article-title":"The epidemiology of appendicitis and appendectomy in South Korea:National registry data","volume":"20","author":"Lee","year":"2010","journal-title":"J Epidemiol"},{"key":"R22-20250410","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3393\/ac.2015.31.5.192","article-title":"Predictive factors to distinguish between patients with noncomplicated appendicitis and those with complicated appendicitis","volume":"31","author":"Kim","year":"2015","journal-title":"Ann Coloproctol"},{"key":"R23-20250410","doi-asserted-by":"crossref","first-page":"398","DOI":"10.23958\/ijirms\/vol06-i06\/1142","article-title":"Risk of perforated appendicitis in patients with hyperbilirubinemia","volume":"6","author":"Ibrahim","year":"2021","journal-title":"Int J Innov Res Med Sci"},{"key":"R24-20250410","doi-asserted-by":"crossref","first-page":"423","DOI":"10.5505\/tjtes.2014.75044","article-title":"The clinical value of leucocyte count and neutrophil percentage in diagnosing uncomplicated (simple) appendicitis and predicting complicated appendicitis","volume":"20","author":"\u015eahbaz","year":"2014","journal-title":"Turk J Trauma Emerg Surg"},{"key":"R25-20250410","first-page":"40","article-title":"Why is the rate of perforated appendicitis higher in girls in Eastern Turkey, unlike the literature?","volume":"54","author":"Avci","year":"2019","journal-title":"Turk Pediatri Ars"},{"key":"R26-20250410","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1445-2197.2012.06185.x","article-title":"Pathologies of the appendix:A 10-year review of 4670 appendicectomy specimens","volume":"82","author":"Chandrasegaram","year":"2012","journal-title":"ANZ J Surg"},{"key":"R27-20250410","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/ans.14088","article-title":"Emergency appendicectomy in Australia:Findings from a multicentre, prospective study","volume":"87","author":"Arthur","year":"2017","journal-title":"ANZ J Surg"},{"key":"R28-20250410","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3393\/jksc.2010.26.6.413","article-title":"Management of appendicitis presenting with abscess or mass","volume":"26","author":"Kim","year":"2010","journal-title":"J Korean Soc Coloproctol"},{"key":"R29-20250410","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/jamasurg.2014.77","article-title":"Time to appendectomy and risk of perforation in acute appendicitis","volume":"149","author":"Drake","year":"2014","journal-title":"JAMA Surg"},{"key":"R30-20250410","first-page":"69","article-title":"Laparoscopic appendectomy for acute and perforated appendicitis:A comparative analysis","volume":"30","author":"Haksal","year":"2019","journal-title":"South Clin Ist Euras"},{"key":"R31-20250410","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/0019-5359.94401","article-title":"Acute perforated appendicitis:An analysis of risk factors to guide surgical decision making","volume":"64","author":"Barreto","year":"2010","journal-title":"Indian J Med Sci"},{"key":"R32-20250410","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/medicina59030533","article-title":"Self-locking polymeric clips are safe for the closure of appendiceal stump in laparoscopic appendectomy","volume":"59","author":"Marcinkeviciute","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"R33-20250410","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.18203\/2349-2902.isj20182488","article-title":"Risk factors of acute and perforated appendicitis in a semi-rural population:A retrospective study","volume":"5","author":"Paidipelly","year":"2018","journal-title":"Int Surg J"},{"key":"R34-20250410","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1308\/003588413X13511609954851","article-title":"Role of the faecolith in modern-day appendicitis","volume":"95","author":"Singh","year":"2013","journal-title":"Ann R Coll Surg Engl"}],"container-title":["International Journal of Applied &amp; Basic Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_529_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:57:50Z","timestamp":1786647470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_529_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijabmr.ijabmr_529_24","relation":{},"ISSN":["2229-516X","2248-9606"],"issn-type":[{"value":"2229-516X","type":"print"},{"value":"2248-9606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-11-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}