{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:35:54Z","timestamp":1787510154784,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hypertensive disorders of pregnancy affect 3%\u20135% of all pregnancies, contributing immensely to maternal morbidity and mortality. According to the WHO, the incidence of deaths due to preeclampsia and eclampsia in developing and developed countries is 2.8% and 0.4%, respectively. Lactate dehydrogenase (LDH) and uric acid are good predictors of disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aims to determine the fetomaternal outcome in relation to abnormal serum levels of LDH and uric acid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A cross-sectional study was carried out in 1200 patients with preeclampsia and eclampsia at a tertiary care center over 2 years. Patients were divided into \u2013 Group A: patients with normal LDH (\u2264300 IU\/L) and uric acid (&lt;6 mg\/dl) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 300). Group B: patients with abnormal LDH and uric acid (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 900), who were further divided into mild and severe preeclampsia and eclampsia. Abnormal serum values were stratified into groups for easier comparison. The results were compared in terms of maternal and perinatal outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The incidence of preeclampsia and eclampsia in our study is 3.14% and 1.57%, respectively. Significant changes in LDH and uric acid were associated with increased severity of the disease (LDH \u2013 1116.94 \u00b1 4.78; uric acid \u2013 9.2 \u00b1 2.89). Higher incidence of maternal and fetal complications was seen with severe preeclampsia and eclampsia with LDH &gt;800 IU\/L and uric acid &gt;6 mg\/dl.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Standard antenatal follow-up should be carried out for early detection and prevention of preeclampsia, with strict monitoring of serum uric acid level and LDH. This may reduce the maternal and fetal complications due to preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijabmr.ijabmr_626_22","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T14:16:51Z","timestamp":1692368211000},"page":"95-100","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["A Study on Serum Lactate Dehydrogenase and Uric Acid in Preeclampsia and Eclampsia: Can they Predict Adverse Fetomaternal Outcome?"],"prefix":"10.4103","volume":"13","author":[{"given":"Jayashree Jayabharati","family":"Moharana","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, SCB Medical College and Hospital, Cuttack, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, SCB Medical College and Hospital, Cuttack, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit Kumar","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, SCB Medical College and Hospital, Cuttack, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"R1-20240902","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: A systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R7-20240902","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0301-2115(02)00269-5","article-title":"Expectant management of severe preeclampsia and preeclampsia superimposed on chronic hypertension between 24 and 34 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