{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:19:29Z","timestamp":1787761169392,"version":"build-2784847793"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders characterized by cytopenias, dysplasia in one or more of the major myeloid cell lines, ineffective hematopoiesis, with cellular marrow, and risk for leukemic transformation. We present a case of a 66-year-old male with a history of multiple packed red blood cell (PRBC) transfusions. Routine investigations, bone marrow aspiration, and biopsy were done. The clinical and morphological findings raised suspicion of MDS with isolated del (5q), so cytogenetics was done. When cytogenetics was done, there was a big mismatch in finding between clinical, morphological, and molecular findings which brought a major change in prognosis as well as treatment. It is, therefore, very essential to not rely only on the clinical and morphological findings to reach a diagnosis. Molecular findings play a pivotal role to come to a final conclusion.<\/jats:p>","DOI":"10.4103\/ijabmr.ijabmr_776_21","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T01:30:37Z","timestamp":1671586237000},"page":"288-290","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["When Clinico-Morphological and Molecular Studies Tell Different Stories: A Case of Myelodysplastic Syndrome"],"prefix":"10.4103","volume":"12","author":[{"given":"Niharika","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Pathology, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Pathology, JLN Medical College, Ajmer, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Pathology, RNT Medical College and Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan Lal","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"R2-20240902","first-page":"1","article-title":"Myelodysplastic syndrome (MDS) with isolated 5q deletion (5q\u2013Syndrome):Report of two cases with review of literature","volume":"7","author":"Mona","year":"2018","journal-title":"World J Pathol"},{"key":"R3-20240902","first-page":"1930","article-title":"Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases","volume":"88","author":"Le Beau","year":"1996","journal-title":"Blood"},{"key":"R4-20240902","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1200\/JCO.1990.8.1.75","article-title":"Prognostic importance of cytogenetic subgroups in de novo pediatric acute nonlymphocytic leukemia","volume":"8","author":"Kalwinsky","year":"1990","journal-title":"J Clin Oncol"},{"key":"R5-20240902","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood.V89.6.2079","article-title":"International scoring system for evaluating prognosis in myelodysplastic syndromes","volume":"89","author":"Greenberg","year":"1997","journal-title":"Blood"}],"container-title":["International Journal of Applied &amp; Basic Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_776_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:25:30Z","timestamp":1787757930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijabmr.ijabmr_776_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijabmr.ijabmr_776_21","relation":{},"ISSN":["2229-516X","2248-9606"],"issn-type":[{"value":"2229-516X","type":"print"},{"value":"2248-9606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2021-12-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}