{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:25:31Z","timestamp":1792275931877,"version":"4.4.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Primary extranodal lymphomas (pENL) are lymphomas with minimal nodal involvement and dominant extranodal disease. We aimed to study the prevalence and clinicopathological characteristics of pENL presenting at our center over 5 years from January 2015 to January 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a cross-sectional study of pENL patients in which relevant clinical and laboratory data was collected including demography, site, stage, international prognostic index-revised, imaging findings, hematological, and biochemical parameters and comorbidities including underlying immunodeficiency. The paraffin blocks were subjected to routine hematoxylin and eosin stain and immunohistochemistry with standard lymphoma panel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 341 lymphomas, 73 (21.4%) were pENL with commonest site being gastrointestinal tract (31.5%) followed by head and neck (23.2%) and soft tissues (9.6%). Diffuse large B-cell lymphoma (DLBCL) (39.7%) was the commonest histological type (germinal center type\u201448%, nongerminal center\u201452%) followed by marginal zone lymphomas (MZL) (23.3%) and primary CNS lymphoma (8.2%). Primary breast lymphoma, primary bone marrow lymphoma, and follicular lymphoma constituted 4.1, 5.4, and 4.1% of pENL, respectively. There was a case of high grade B cell lymphoma of ileum with features intermediate between DLBCL and Burkitt. Other unusual pENL were anaplastic DLBCL of tonsils, DLBCLs of bone marrow with M band, MZL of base of tongue, Richter\u2019s transformation of tonsillar small lymphocytic lymphoma, and follicular lymphoma presenting as pericardial mass. Of 12 cases of T-non-Hodgkin lymphoma, commonest were mycosis fungoides (4\/12) followed by mediastinal T-lymphoblastic lymphoma (2\/12) and peripheral T-cell lymphoma (2\/12).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>pENL has unique clinical presentation depending on the location with site-specific distribution of histological subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_1267_20","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:18:15Z","timestamp":1702444695000},"page":"16-21","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Primary extranodal lymphomas: Five-year experience from a tertiary care center of North India"],"prefix":"10.4103","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-2173","authenticated-orcid":false,"given":"Priyanka","family":"Mishra","sequence":"first","affiliation":[{"name":"Departments of Pathology, Command Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-4235","authenticated-orcid":false,"given":"Manoj","family":"Prashar","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Command Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-6544","authenticated-orcid":false,"given":"Nidhin","family":"Rehman","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Command Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0378-0378","authenticated-orcid":false,"given":"Anamika","family":"Sinha","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Command Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-1109","authenticated-orcid":false,"given":"Deep K.","family":"Raman","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Command Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/0277-5379(91)90081-N","article-title":"Clinicopathological features and prognostic factors in extranodal non-Hodgkin lymphomas. 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