{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:33Z","timestamp":1787772153324,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"\n \n \n A spectrum of Cellular homolog of the v-myc oncogene (\n cMYC)<\/jats:italic>\n alterations such as translocation, overexpression, mutation, and amplification plays an important role in lymphomagenesis, particularly in high-grade lymphomas, and are associated with prognostic significance. Accurate identification of\n cMYC<\/jats:italic>\n gene alteration is important for diagnostic, prognostic, and therapeutic implications. With the application of different FISH (fluorescence\n in situ<\/jats:italic>\n hybridization) probes that helped overcome the analytical diagnostic challenges as a result of variant patterns, we report rare, concomitant, and independent gene alterations in\n cMYC<\/jats:italic>\n and Immunoglobulin heavy-chain gene (\n IGH)<\/jats:italic>\n with detailed characterization of its variant rearrangement. Short-term follow-up post R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy seemed to be favorable. Accumulation of many more literature studies on such cases with their therapeutic implications would lead to the categorization of these cases as a separate subclass in large B-cell lymphomas followed by molecular targeted therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijc.ijc_1292_20","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T06:29:05Z","timestamp":1712730545000},"page":"548-551","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Atypical MYC rearrangement pattern of 3\u2019 deletion and 5\u2019 amplification along with independent IGH rearrangement"],"prefix":"10.4103","volume":"59","author":[{"given":"Sandhya","family":"Kandoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ushang","family":"Kate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabal","family":"Deb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangita S.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Vignesh","family":"Kanda Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurita P.","family":"Pais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20240828","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/genes8040116","article-title":"The Role of c-MYC in B-Cell lymphomas: Diagnostic and molecular aspects","volume":"8","author":"Nguyen","year":"2017","journal-title":"Genes (Basel"},{"key":"R2-15-20240828","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1002\/cncr.31646","article-title":"Double hit and double expressors in lymphoma: Definition and treatment","volume":"124","author":"Riedell","year":"2018","journal-title":"Cancer"},{"key":"R3-15-20240828","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/bjh.14282","article-title":"Sole rearrangement but not amplification of MYC is associated with a poor prognosis in patients with diffuse large B cell lymphoma and B cell lymphoma unclassifiable","volume":"175","author":"Landsburg","year":"2016","journal-title":"Br J Haematol"},{"key":"R4-15-20240828","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1182\/bloodadvances.2018023572","article-title":"High-resolution architecture and partner genes of MYC rearrangements in lymphoma with DLBCL morphology","volume":"2","author":"Chong","year":"2018","journal-title":"Blood Adv"},{"key":"R5-15-20240828","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1158\/1078-0432.CCR-15-2296","article-title":"Clinical and biologic significance of MYC genetic mutations in De Novo diffuse large B-cell lymphoma","volume":"22","author":"Xu-Monette","year":"2016","journal-title":"Clin Cancer Res"},{"key":"R6-15-20240828","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1182\/blood.V120.21.1552.1552","article-title":"MYC Gene FISH testing in aggressive B-Cell lymphomas: Atypical rearrangements may result in underreporting of positive cases","volume":"120","author":"Sun","year":"2012","journal-title":"Blood"},{"key":"R7-15-20240828","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41408-019-0271-z","article-title":"High level MYC amplification in B-cell lymphomas: Is it a marker of aggressive disease?","volume":"10","author":"Pophali","year":"2020","journal-title":"Blood Cancer J"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_1292_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:31:05Z","timestamp":1787769065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_1292_20"}},"subtitle":["A case study"],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_1292_20","relation":{},"ISSN":["0019-509X"],"issn-type":[{"value":"0019-509X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]}}}