{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:01Z","timestamp":1787772421062,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Granulosa cell tumors of the ovary represent the most common sex-cord stromal tumors. Though characterized by an indolent course and a good five-year survival rate, they tend to have late recurrences and subsequent poorer survival. The role of hyperthermic intraperitoneal chemotherapy (HIPEC) in women with recurrent granulosa cell tumors with peritoneal dissemination has not been well defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      All patients with adult or juvenile type granulosa cell tumors who underwent cytoreductive surgery with HIPEC with 70 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      of cisplatin for 60 minutes over a period of four years were retrospectively evaluated. We also performed a review of the literature on similar cases reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified eight patients with recurrent adult granulosa cell tumors (AGCT) who fulfilled our inclusion criteria. The mean operative duration was 340 minutes, inclusive of the duration of HIPEC. Fifty percent of patients suffered from postoperative morbidity. Grade 4 morbidity was observed in one patient. At a median follow-up of 35 months, four patients experienced disease recurrence. The median disease-free survival was 10 months (range: 6\u201331 months) and the median overall survival was 11.5 months (range: 7\u201340 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Cytoreductive surgery (CRS) and HIPEC provides a unique opportunity for treating peritoneal dissemination in patients with recurrent ovarian AGCTs. This procedure is well tolerated with acceptable morbidity. Prospective studies are warranted to further elucidate the efficacy of this novel therapeutic approach in recurrent ovarian granulosa cell tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_1454_21","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:18:15Z","timestamp":1702444695000},"page":"156-165","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Is there a role of cytoreductive surgery with HIPEC in recurrent ovarian granulosa cell tumors? An Indian cancer center experience with review of literature"],"prefix":"10.4103","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-3944","authenticated-orcid":false,"given":"Mukurdipi","family":"Ray","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-6876","authenticated-orcid":false,"given":"Aarthi S.","family":"Jayraj","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-7401","authenticated-orcid":false,"given":"Kunal","family":"Dhall","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-4587","authenticated-orcid":false,"given":"Rambha","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-8234","authenticated-orcid":false,"given":"Suryanarayana V. S.","family":"Deo","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"issue":"(Suppl 2)","key":"R1-20240828","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0893-3952(22)04460-X","article-title":"Sex cord-stromal tumors of the ovary and testis:Their similarities and differences with consideration of selected problems","volume":"18","author":"Young","year":"2005","journal-title":"Mod Pathol"},{"key":"R2-20240828","first-page":"307","article-title":"WHO Classification of tumors of Female Reproductive Organs","author":"Kurman","year":"2014","journal-title":"International Agency for Research on Cancer (IARC), Lyon"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13048-020-00619-6","article-title":"Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary","volume":"13","author":"Zhao","year":"2020","journal-title":"J Ovarian Res"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ygyno.2013.04.047","article-title":"Recurrent granulosa cell tumors (GCTs) of the ovary:A MITO-9 retrospective study","volume":"130","author":"Mangili","year":"2013","journal-title":"Gynecol Oncol"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/IGC.0000000000000077","article-title":"Effectiveness of chemotherapy in measurable granulosa cell tumors:A retrospective study and review of literature","volume":"24","author":"van Meurs","year":"2014","journal-title":"Int J Gynecol Cancer"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/gyno.1998.5287","article-title":"Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary","volume":"73","author":"Wolf","year":"1999","journal-title":"Gynecol Oncol"},{"key":"R7-20240828","first-page":"CD006912","article-title":"Effectiveness of different treatment modalities for the management of adult-onset granulosa cell tumors of the ovary (primary and recurrent)","volume":"2014","author":"Gurumurthy","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"R8-20240828","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJMoa1708618","article-title":"Hyperthermic intraperitoneal chemotherapy in ovarian cancer","volume":"378","author":"van Driel","year":"2018","journal-title":"N Engl J Med"},{"key":"R9-20240828","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ygyno.2012.09.020","article-title":"Cytoreductive surgery plus HIPEC in platinum-sensitive recurrent ovarian cancer patients:A case\u2013control study on survival in patients with two year follow-up","volume":"127","author":"Fagotti","year":"2012","journal-title":"Gynecol Oncol"},{"key":"R10-20240828","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-1-4613-1247-5_23","article-title":"Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis","volume":"82","author":"Jacquet","year":"1996","journal-title":"Cancer Treat Res"},{"key":"R11-20240828","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00000658-199501000-00004","article-title":"Peritonectomy procedures","volume":"221","author":"Sugarbaker","year":"1995","journal-title":"Ann Surg"},{"key":"R12-20240828","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ygyno.2010.06.031","article-title":"Adult granulosa cell tumors of the ovary:Tumor dissemination pattern at primary and recurrent situation, surgical outcome","volume":"119","author":"Fotopoulou","year":"2010","journal-title":"Gynecol Oncol"},{"key":"R13-20240828","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1111\/jog.13969","article-title":"Aggressive adult granulosa cell tumor of the ovary without a FOXL2 mutation:A case report","volume":"45","author":"Watanabe","year":"2019","journal-title":"J Obstet Gynaecol Res"},{"key":"R14-20240828","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/dc.23535","article-title":"Cytomorphology and clinicopathologic correlation of the recurrent and metastatic adult granulosa cell tumor of the ovary:A retrospective review","volume":"44","author":"Harbhajanka","year":"2016","journal-title":"Diagn Cytopathol"},{"key":"R15-20240828","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.ejso.2013.09.030","article-title":"Peritoneal carcinomatosis treated with cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced ovarian carcinoma:A French multicentre retrospective cohort study of 566 patients","volume":"39","author":"Bakrin","year":"2013","journal-title":"Eur J Surg Oncol"},{"key":"R16-20240828","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1245\/s10434-014-4157-9","article-title":"Cytoreductive surgery and HIPEC in recurrent epithelial ovarian cancer:A prospective randomized phase III study","volume":"22","author":"Spiliotis","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"R17-20240828","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1055\/s-2002-35536","article-title":"Continuous intraoperative intraperitoneal hyperthermic chemoperfusion (CIIPHCP) in the treatment of advanced stage and recurrent granulosa cell tumors. Report of two cases","volume":"124","author":"Chatzigeorgiou","year":"2002","journal-title":"Zentralbl Gynakol"},{"key":"R18-20240828","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3802\/jgo.2011.22.3.214","article-title":"Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary","volume":"22","author":"Chua","year":"2011","journal-title":"J Gynecol Oncol"},{"key":"R19-20240828","first-page":"2435","article-title":"Management of peritoneal dissemination of recurrences granulosa cell tumor of the ovary","volume":"39","author":"Canbay","year":"2012","journal-title":"Gan To Kagaku Ryoho"},{"key":"R20-20240828","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ejogrb.2013.06.041","article-title":"Results of oxaliplatin-based hyperthermic intraperitoneal chemotherapy in recurrent ovarian granulosa cell tumors","volume":"170","author":"Gouy","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R21-20240828","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1111\/jog.12460","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for management of recurrent\/relapsed ovarian granulosa cell tumor:A single-center experience:CRS+HIPEC for recurrent\/relapsed OGCT","volume":"40","author":"Al-Badawi","year":"2014","journal-title":"J Obstet Gynaecol Res"},{"key":"R22-20240828","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00383-015-3814-9","article-title":"Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric ovarian tumors:A novel treatment approach","volume":"32","author":"Hayes-Jordan","year":"2016","journal-title":"Pediatr Surg Int"},{"key":"R23-20240828","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.gore.2016.03.005","article-title":"Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy for recurrent adult granulosa cell tumor:A case report","volume":"16","author":"Dogan","year":"2016","journal-title":"Gynecol Oncol Rep"},{"key":"R24-20240828","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1515\/pp-2017-0017","article-title":"Uncommon indications for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"2","author":"Yee","year":"2017","journal-title":"Pleura Peritoneum"},{"key":"R25-20240828","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1245\/s10434-018-6464-z","article-title":"Peritoneal carcinomatosis of rare ovarian origin treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy:A multi-institutional cohort from PSOGI and BIG-RENAPE","volume":"25","author":"Mercier","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"R26-20240828","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/jog.14494","article-title":"Management of recurrent granulosa cell tumor of the ovary:Contemporary literature review and a proposal of hyperthermic intraperitoneal chemotherapy as novel therapeutic option","volume":"47","author":"Yasukawa","year":"2021","journal-title":"J Obstet Gynaecol Res"},{"key":"R27-20240828","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jpag.2016.09.008","article-title":"Juvenile granulosa cell tumor of the ovary:A clinicopathologic study","volume":"30","author":"Wu","year":"2017","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"(15_suppl)","key":"R28-20240828","article-title":"Juvenile granulosa cell tumor:An interim report from the international ovarian and testicular stromal tumor (OTST) registry","volume":"38","author":"Harris","year":"2020","journal-title":"JCO"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_1454_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:45:41Z","timestamp":1787769941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_1454_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_1454_21","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2021-12-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}