{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:25:45Z","timestamp":1789471545978,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. The standard management has been maximum surgical resection followed by adjuvant radiotherapy with concurrent chemotherapy followed by adjuvant chemotherapy. Although the survival rate of patients with GBM has improved with recent advancements in treatment, the prognosis remains generally poor. The median survival rates are in the range of 9\u201312 months and 2-year survival rates are in the range of 8%\u201312%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>A single-institution retrospective review of 61 patients of GBM from 2012 to 2014. Data regarding patient factors, disease factors, and treatment factors were collected and survival has been calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 61 patients with GBM were analyzed. GBM is commonly seen in sixth decade of life. Male to female ratio is 2.6:1. The right side of the brain is commonly involved with right frontal lobe being the most common site. The median follow-up was 4.6 months. The median survival of our patients was 8 months. The 1-year and 2-year survival rates were 20% and 3.27%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The overall survival and prognosis in patients with GBM remains poor despite of constant research and studies. Concurrent chemoradiotherapy followed by adjuvant chemotherapy with temozolomide should be used after maximal resection to improve the survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_157_17","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:43:22Z","timestamp":1513817002000},"page":"362-367","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":36,"title":["Survival and prognostic factors for glioblastoma multiforme: Retrospective single-institutional study"],"prefix":"10.4103","volume":"54","author":[{"given":"M","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Mahavir Cancer Sansthan, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Shubham","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mahavir Cancer Sansthan, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mahavir Cancer Sansthan, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mahavir Cancer Sansthan, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mahavir Cancer Sansthan, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Naseera","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mahavir Cancer Sansthan, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"issue":"Suppl 2","key":"R2-20250920","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1093\/neuonc\/not151","article-title":"CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010","volume":"15","author":"Ostrom","year":"2013","journal-title":"Neuro Oncol"},{"key":"R3-20250920","first-page":"9","article-title":"History of surgical treatment of brain tumors","volume":"6","author":"\u017bukiel","year":"2004","journal-title":"Neuroskop"},{"key":"R4-20250920","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/jnen\/64.6.479","article-title":"Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas","volume":"64","author":"Ohgaki","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"R5-20250920","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1158\/0008-5472.CAN-04-1337","article-title":"Genetic pathways to glioblastoma: A population-based study","volume":"64","author":"Ohgaki","year":"2004","journal-title":"Cancer Res"},{"key":"R6-20250920","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/neuonc\/1.1.44","article-title":"Primary and secondary glioblastomas: From concept to clinical diagnosis","volume":"1","author":"Kleihues","year":"1999","journal-title":"Neuro Oncol"},{"key":"R7-20250920","first-page":"649","article-title":"Glioblastoma multiforme with tuberous sclerosis. 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