{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:07:13Z","timestamp":1787170033022,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with a biopsy-confirmed cervical intraepithelial neoplasia 2 and 3 have an increased risk of disease progression to invasive cancer and should be treated with an excisional method. However, after treatment with an excisional method, a high-grade residual lesion may remain in patients with positive surgical margins. We aimed to investigate the risk factors for a residual lesion in patients with a positive surgical margin after cervical cold knife conization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Records of 1008 patients who underwent conization at a tertiary gynecological cancer center were retrospectively reviewed. One hundred and thirteen patients with a positive surgical margin after cold knife conization were included in the study. We have retrospectively analyzed the characteristics of the patients treated with re-conization or hysterectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Residual disease was identified in 57 (50.4%) patients. The mean age of the patients with residual disease was 42.47 \u00b1 8.75 years. Age greater than 35 years (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002; OR, 4.926; 95%CI [Confidence Interval] - 1.681-14.441), more than one involved quadrant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003; OR, 3.200; 95% CI - 1.466-6.987), and glandular involvement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002; OR, 3.348; 95% CI - 1.544-7.263) were risk factors for residual disease. The rate of high-grade lesion positivity in post-conization endocervical biopsy at initial conization was similar between patients with and without residual disease (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.16). The final pathology of the residual disease was microinvasive cancer in four patients (3.5%) and invasive cancer in one patient (0.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In conclusion, residual disease is found in about half of the patients with a positive surgical margin. In particular, we found that age greater than 35 years, glandular involvement, and more than 1 involved quadrant were associated with the residual disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_238_20","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T01:30:35Z","timestamp":1669771835000},"page":"390-395","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The characteristics of the residual disease after cervical conization: A retrospective analysis from a tertiary gynecological cancer center"],"prefix":"10.4103","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-6634","authenticated-orcid":false,"given":"Burak","family":"Giray","sequence":"first","affiliation":[{"name":"Department of Gynaecologic Oncology, University of Health Sciences, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-279X","authenticated-orcid":false,"given":"Canan","family":"Kabaca","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, University of Health Sciences, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9327-9685","authenticated-orcid":false,"given":"Mine Guray","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, University of Health Sciences, Zeynep Kamil Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/jnci\/djp089","article-title":"Cervical intraepithelial neoplasia outcomes 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