{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:30:40Z","timestamp":1786649440441,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Non-carcinoid appendix epithelial tumors are rare. These tumors include low-grade and high-grade mucinous neoplasm also adenocarcinomas. We aimed to investigate the clinicopathological features, treatment, and risk factors of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients diagnosed between 2008 and 2019 were retrospectively analyzed. Categorical variables were expressed as percentages and compared using the Chi-square test or Fisher\u2019s exact tests. Overall survival and Disease-free survival of the groups were calculated by the Kaplan\u2013Meier method, and the log-rank test was used to compare the survival rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 35 patients were included in the study. Of the patients, 19 (54%) were women and the median diagnosis age of patients was 50.4 years (19\u201376). As for pathological types, a total of 14 (40%) patients were mucinous adenocarcinoma and 14 (40%) patients were Low-Grade Mucinous Neoplasm (LGMN). Lymph node excision and lymph node involvement were 23 (65%) and 9 (25%) patients respectively. The majority of patients were stage 4 (27, 79%) and 25 (71%) of these patients had peritoneal metastasis. A total of 48.6% patients had been treated with cytoreductive surgery and hyper-thermic intraperitoneal chemotherapy. Median Peritoneal cancer index value was 12 (2-36). The median follow-up time was 20 (1-142) months. Recurrence developed in 12 (34%) of patients. When risk factors for recurrence are considered, there was a statistically significant difference in appendix tumors with high-grade, adenocarcinoma pathology, ones with peritoneal cancer index \u226512 and not having pseudomyxoma peritonei. Median disease-free survival was 18 (13-22, 95% CI) months. Median overall survival could not be reached while the 3-year survival rate was 79%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The risk of recurrence is higher in high-grade appendix tumors, having peritoneal cancer index \u2265 12, not having pseudomyxoma peritonei and adenocarcinoma pathology. High-grade appendix adenocarcinoma patients should be followed closely for recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_395_20","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T01:32:45Z","timestamp":1665538365000},"page":"305-311","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological features of non-carcinoid malignant epithelial appendix tumors and risk factors for recurrence, single-center experience"],"prefix":"10.4103","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0182-3933","authenticated-orcid":false,"given":"Ozturk","family":"Ates","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Dr. A. Y. Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-664X","authenticated-orcid":false,"given":"Bulent","family":"Aksel","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr. A. Y. Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-6790","authenticated-orcid":false,"given":"Ibrahim","family":"Karadag","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dr. A. Y. Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-7131","authenticated-orcid":false,"given":"Serdar","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dr. A. Y. Ankara Oncology Education and Research Hospital, Health Sciences University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-4621","authenticated-orcid":false,"given":"Veli","family":"Sunar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dr. Zekai Tahir Burak Women Health Education and Research Hospital, Health Sciences University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-8646","authenticated-orcid":false,"given":"O. Berna","family":"Oksuzoglu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dr. A. Y. 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A review of the literature with special reference to optimal surgical procedures","volume":"37","author":"Hata","year":"2002","journal-title":"J Gastroenterol"},{"key":"R15-20260426","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/cncr.29744","article-title":"The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: Analysis of the National Cancer Data Base","volume":"122","author":"Asare","year":"2016","journal-title":"Cancer"},{"key":"R16-20260426","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/cncr.24715","article-title":"Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin: A single-institution experience","volume":"116","author":"Shapiro","year":"2010","journal-title":"Cancer"},{"key":"R17-20260426","article-title":"Recurrence of pseudomyxoma peritonei after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy-Mercier-2019-BJS Open-Wiley Online Library [Internet]"},{"key":"R18-20260426","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1200\/JCO.2011.39.7166","article-title":"Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"30","author":"Chua","year":"2012","journal-title":"J Clin Oncol"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_395_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:54:11Z","timestamp":1786647251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_395_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,12]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_395_20","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,12]]},"assertion":[{"value":"2020-04-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}