{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:43:29Z","timestamp":1787071409492,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the association between serum C-reactive protein-to-albumin ratio (CAR) and the prognosis of multiple myeloma (MM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this single-center retrospective cohort study, a total of 321 patients diagnosed with MM were enrolled between February 2008 and December 2020. All patients were divided into two groups according to the optimal cutoff value of CAR. Cox proportional hazard regression model and receiver operating characteristic (ROC) curve analysis were conducted to assess the prognostic predictive value of CAR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Higher CAR was significantly associated with shorter overall survival (OS), cause-specific survival (CSS), and progression-free survival (PFS) (HR = 1.864, 95%CI = 1.287\u20132.699,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for OS; HR = 1.916, 95%CI = 1.052\u20132.546,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for CSS; HR = 1.748, 95%CI = 1.291\u20132.367,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001 for PFS). The significance remained after multivariable logistic regression analysis (HR = 1.628, 95%CI = 1.066\u20132.485,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.024 for OS; HR = 1.636, 95%CI = 1.052\u20132.546,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.029 for CSS; HR = 1.666, 95%CI = 1.185\u20132.343,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003 for PFS). CAR demonstrated significantly higher predictive power compared to both albumin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) and C-reactive protein (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) in terms of OS, CSS, and PFS. The composite variable exhibited the highest predictive value (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Higher CAR was found to be an independent predictor for the poor prognosis of MM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_3_24","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T07:00:10Z","timestamp":1763794810000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Association between serum C-reactive protein-to-albumin ratio and the prognosis of patients with multiple myeloma"],"prefix":"10.4103","volume":"62","author":[{"given":"Fengjuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology, Panzhihua Central Hospital, Panzhihua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Panzhihua Central Hospital, Panzhihua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Panzhihua Central Hospital, Panzhihua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Panzhihua Central Hospital, Panzhihua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1249-5147","authenticated-orcid":false,"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Panzhihua Central Hospital, Panzhihua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"R1-20251122","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.6004\/jnccn.2019.0049","article-title":"NCCN guidelines insights:Multiple myeloma, version 1.2020","volume":"17","author":"Kumar","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"R2-20251122","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/leu.2013.313","article-title":"Continued improvement in survival in multiple myeloma:Changes in early mortality and outcomes in older patients","volume":"28","author":"Kumar","year":"2014","journal-title":"Leukemia"},{"key":"R3-20251122","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.7150\/jca.31357","article-title":"Identification of high serum apolipoprotein A1 as a favorable prognostic indicator in patients with multiple myeloma","volume":"10","author":"Liang","year":"2019","journal-title":"J Cancer"},{"key":"R4-20251122","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U","article-title":"A clinical staging system for multiple myeloma. 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