{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:09Z","timestamp":1790776569417,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Identifying hereditary colorectal cancer genes is historically complicated by genetic heterogeneity. Founder populations simplify genetic architecture through reduced allelic diversity and extended linkage disequilibrium. This write-up explores how Finland\u2019s unique demographic history, driven by geographic isolation and severe population bottlenecks, established the distinct \u201cFinnish disease heritage.\u201d In the 1990s, this regional homogeneity proved instrumental in successfully mapping recurrent germline\n                    <jats:italic toggle=\"yes\">MLH1<\/jats:italic>\n                    (MutL Homolog 1) founder mutations in Lynch syndrome.\n                  <\/jats:p>","DOI":"10.4103\/ijc.ijc_415_26","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:00:08Z","timestamp":1786600808000},"page":"114-119","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Finnish founder population and MLH1 mutations in hereditary colorectal cancer"],"prefix":"10.4103","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1444-2559","authenticated-orcid":false,"given":"Nirmal Raj","family":"Rajaram","sequence":"first","affiliation":[{"name":"Department of Oncology, Medical Sciences Division, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1669-0091","authenticated-orcid":false,"given":"Paramjot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Nephrology, All India Institute of Medical Sciences (AIIMS), Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"R2-20260930","first-page":"1243","article-title":"Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer","volume":"59","author":"Moisio","year":"1996","journal-title":"Am J Hum Genet"},{"key":"R3-20260930","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ajpa.1330770306","article-title":"Founder effect and genetic disease in Sottunga, Finland","volume":"77","author":"O\u2019Brien","year":"1988","journal-title":"Am J Phys Anthropol"},{"key":"R4-20260930","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000022794","article-title":"Mapping genes through the use of linkage disequilibrium generated by genetic drift: \u2018Drift mapping\u2019 in small populations with no demographic expansion","volume":"48","author":"Terwilliger","year":"1998","journal-title":"Hum Hered"},{"key":"R5-20260930","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/jmg.30.10.857","article-title":"Disease gene mapping in isolated human populations: The example of Finland","volume":"30","author":"de la Chapelle","year":"1993","journal-title":"J Med Genet"},{"key":"R6-20260930","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1601-5223.1972.tb01021.x","article-title":"The Finnish population structure. 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