{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:34Z","timestamp":1790776594783,"version":"4.1.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sleep disturbances and fatigue are common in patients with head and neck cancer and adversely affect quality of life. Melatonin may improve sleep quality with minimal adverse effects. This study evaluated the effect of oral melatonin on sleep quality, fatigue, and caregiver sleep perception in patients with head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this prospective, randomised, placebo-controlled trial, 70 patients aged 18\u201365 years with head and neck cancer and sleep disturbances for &gt;1 month were randomised to oral melatonin 3 mg (Group M,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 35) or multivitamin (placebo) (Group P,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 35) once daily for 14 days. Pittsburgh sleep quality index (PSQI), fatigue assessment scale (FAS), and satisfaction, alertness, timing, efficiency, and duration scores were assessed at baseline and day 14.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Day-14 PSQI scores were lower in Group M than Group P (8.11 \u00b1 1.55 versus 9.66 \u00b1 1.83;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0003), with significant improvement only in Group M (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). FAS scores were also lower in Group M (12.66 \u00b1 2.44 versus 14.69 \u00b1 1.94;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0003). Caregiver sleep perception improved significantly with melatonin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Oral melatonin improved sleep quality and reduced fatigue in patients with head and neck cancer and was associated with better caregiver sleep perception.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_458_26","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:19:58Z","timestamp":1788949198000},"page":"134-139","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of oral melatonin on sleep quality, fatigue, and caregiver sleep perception in patients with head and neck cancer: A randomized double-blind placebo-controlled trial"],"prefix":"10.4103","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8677-3361","authenticated-orcid":false,"family":"Pushpa","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1400-6721","authenticated-orcid":false,"given":"Madhu","family":"Dayal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3366-5234","authenticated-orcid":false,"given":"Sakshi","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4212-2687","authenticated-orcid":false,"given":"Rohan","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Department of Neuro-Anaesthesia and Intensive Care, Max Super Speciality Hospital, Saket, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1277-2426","authenticated-orcid":false,"given":"Rahul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3725-1805","authenticated-orcid":false,"given":"Ankush","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Indraprastha Apollo, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"R1-20260930","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1200\/JCO.2001.19.3.895","article-title":"Insomnia in the context of cancer: A review of a neglected problem","volume":"19","author":"Savard","year":"2001","journal-title":"J Clin Oncol"},{"key":"R2-20260930","first-page":"809","article-title":"Sleep disturbance in adults with cancer: A systematic review of evidence for best practices in assessment and management","volume":"22","author":"Howell","year":"2014","journal-title":"Support Care Cancer"},{"key":"R3-20260930","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(11)60750-2","article-title":"Chronic insomnia","volume":"379","author":"Morin","year":"2012","journal-title":"Lancet"},{"key":"R4-20260930","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4103\/0973-1075.185039","article-title":"The efficacy of oral melatonin in improving sleep in cancer patients with insomnia: A randomized double-blind placebo-controlled study","volume":"22","author":"Kurdi","year":"2016","journal-title":"Indian J Palliat Care"},{"key":"R5-20260930","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1056\/NEJM199701163360306","article-title":"Melatonin in humans","volume":"336","author":"Brzezinski","year":"1997","journal-title":"N Engl J Med"},{"key":"R6-20260930","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5664\/jcsm.5490","article-title":"Effect of melatonin on sleep in the perioperative period after breast cancer surgery: A randomized, double-blind, placebo-controlled trial","volume":"12","author":"Madsen","year":"2016","journal-title":"J Clin Sleep Med"},{"key":"R7-20260930","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a mitochondria-targeted antioxidant: One of evolution\u2019s best ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"R8-20260930","doi-asserted-by":"crossref","first-page":"e63773","DOI":"10.1371\/journal.pone.0063773","article-title":"Meta-analysis: Melatonin for the treatment of primary sleep disorders","volume":"8","author":"Ferracioli-Oda","year":"2013","journal-title":"PLoS One"},{"key":"R9-20260930","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00002820-200308000-00001","article-title":"Family caregivers\u2019 sleep loss and depression over time","volume":"26","author":"Carter","year":"2003","journal-title":"Cancer Nurs"},{"key":"R10-20260930","first-page":"125","article-title":"Trajectories of fatigue and sleep disturbance in family caregivers of patients undergoing radiation therapy for prostate cancer","volume":"12","author":"Fletcher","year":"2008","journal-title":"Eur J Oncol Nurs"},{"key":"R11-20260930","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"key":"R12-20260930","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0022-3999(02)00392-6","article-title":"Psychometric qualities of a brief self-rated fatigue measure: The Fatigue Assessment Scale","volume":"54","author":"Michielsen","year":"2003","journal-title":"J Psychosom Res"},{"key":"R13-20260930","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5665\/sleep.3298","article-title":"Sleep health: Can we define it? Does it matter?","volume":"37","author":"Buysse","year":"2014","journal-title":"Sleep"},{"key":"R14-20260930","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1513\/AnnalsATS.201908-628OC","article-title":"Validation of the Satisfaction, Alertness, Timing, Efficiency and Duration (SATED) questionnaire for sleep health measurement","volume":"17","author":"Ben\u00edtez","year":"2020","journal-title":"Ann Am Thorac Soc"},{"key":"R15-20260930","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrclinonc.2014.127","article-title":"Cancer-related fatigue\u2014Mechanisms, risk factors, and treatments","volume":"11","author":"Bower","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"key":"R16-20260930","doi-asserted-by":"crossref","first-page":"e060912","DOI":"10.1136\/bmjopen-2022-060912","article-title":"Effect of melatonin on quality of life and symptoms in patients with cancer: A systematic review and meta-analysis of randomised controlled trials","volume":"12","author":"Fan","year":"2022","journal-title":"BMJ Open"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_458_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:06:04Z","timestamp":1790773564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_458_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_458_26","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-07-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}