{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:33:48Z","timestamp":1787070828225,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n To describe three cases of radiation-induced lung injury (RILI) occurring outside the radiation field and to review clinical, radiologic, and histologic aspects of RILI outside the radiation field.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We present case reports of three men with a mean age of 57.6 years, who had received radiation therapy and concomitant chemotherapy for supraglottic and laryngeal carcinoma. A detailed clinical, radiological, and laboratory evaluation was carried out to confirm the diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n All our three patients developed radiation pneumonitis about 4 to 8 weeks after the completion of radiotherapy. All the three patients received radiation in the neck region. The lung infiltrates had developed outside the radiation field. Computed tomography of the chest showed ground glass opacity in the lower lung zones. One patient had grade 2 radiation pneumonitis, while the other two had grade 1. Two patients had grade 1 radiation pneumonitis spontaneously resolved, while one patient was advised inhaled steroids, though he was lost to follow-up.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n RILI may occur away from the site of irradiation due to immunological and non-dosimetric factors. It is important to diagnose RILI at the earliest as management would vary with the grade of RILI. Grade 1 RILI may resolve spontaneously.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijc.ijc_461_22","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T07:00:23Z","timestamp":1763794823000},"page":"332-336","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Radiation-induced lung injury due to extra thoracic irradiation"],"prefix":"10.4103","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-378X","authenticated-orcid":false,"given":"Shweta","family":"Anand","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, ESI-PGIMSR, Basaidarapur, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7386-8818","authenticated-orcid":false,"given":"Dipti","family":"Gothi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, ESI-PGIMSR, Basaidarapur, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, ESI-PGIMSR, Basaidarapur, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-6991","authenticated-orcid":false,"given":"Mahismita","family":"Patro","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, ESI-PGIMSR, Basaidarapur, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Lung Transplant, Max Hospital, Vaishali, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"R1-20251122","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12890-020-01376-4","article-title":"Radiation-induced lung injury:Current evidence","volume":"21","author":"Arroyo-Hern\u00e1ndez","year":"2021","journal-title":"BMC Pulm Med"},{"key":"R2-20251122","first-page":"437","article-title":"Radiation therapy-associated toxicity:Etiology, management, and prevention","volume":"71","author":"Wang","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"R3-20251122","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3390\/clinpract11030056","article-title":"Radiation-induced lung injury-current perspectives and management","volume":"11","author":"Rahi","year":"2021","journal-title":"Clin Pract"},{"key":"R4-20251122","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fonc.2019.00877","article-title":"Radiation-induced lung injury (RILI)","volume":"9","author":"Giuranno","year":"2019","journal-title":"Front Oncol"},{"key":"R5-20251122","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.chest.2019.03.033","article-title":"Radiation-induced lung injury","volume":"156","author":"Hanania","year":"2019","journal-title":"Chest"},{"key":"R6-20251122","doi-asserted-by":"crossref","first-page":"97","DOI":"10.6058\/jlc.2012.11.2.97","article-title":"Bilateral diffuse radiation pneumonitis caused by unilateral thoracic irradiation:A case report","volume":"11","author":"Song","year":"2012","journal-title":"J Lung Cancer"},{"key":"R8-20251122","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.semradonc.2014.12.003","article-title":"Non-dosimetric risk factors for radiation-induced lung toxicity","volume":"25","author":"Kong","year":"2015","journal-title":"Semin Radiat Oncol"},{"key":"R9-20251122","first-page":"614984","article-title":"Radiation pneumonitis after radiotherapy of neck lymphoma","volume":"2014","author":"Wei","year":"2014","journal-title":"Case Rep Pulmonol"},{"key":"R10-20251122","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12609-017-0234-y","article-title":"The abscopal effect of radiation therapy:What is it and how can we use it in breast cancer?","volume":"9","author":"Hu","year":"2017","journal-title":"Curr Breast Cancer Rep"},{"key":"R12-20251122","first-page":"199","article-title":"Use of nanoparticle albumin-bound paclitaxel in patients with breast cancer and paclitaxel-induced pneumonitis:Single-center case series","volume":"9","author":"Alison Palumbo","year":"2019","journal-title":"J Hematol Oncol Pharm"},{"key":"R13-20251122","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.1097\/RLU.0000000000003445","article-title":"Docetaxel-induced interstitial pneumonitis detected on 68Ga-PSMA PET\/CT","volume":"46","author":"Kumar","year":"2021","journal-title":"Clin Nucl Med"},{"key":"R14-20251122","first-page":"1813","article-title":"Docetaxel-related interstitial pneumonitis","volume":"11","author":"Wang","year":"2015","journal-title":"Ther Clin Risk Manag"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_461_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:37:15Z","timestamp":1787067435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_461_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_461_22","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2022-04-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}