{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:26Z","timestamp":1790776586865,"version":"4.1.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the prognostic impact of perineural invasion (PNI) on oncological outcomes in oral cavity carcinoma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Chart review of 781 patients undergoing surgery for oral cavity carcinoma between 2013 to 2021 was done. All patients underwent surgery (per primum\/post neoadjuvant chemotherapy) followed by adjuvant treatment as per histopathological report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 653 male patients (83%) and the median age of the cohort was 48 years. Six hundred and thirty-two (80.8%) patients had locally advanced stage (III\/IV). Three hundred and forty (44%) patients had PNI reported. PNI positivity correlated with higher pT stage, pN stage, overall stage and poor differentiation. Median follow-up was 51 months. At last follow-up, 571 patients (73%) were alive, of which 527 were disease free. Incidence of distant metastasis was significantly higher in patients having PNI (25% versus 13%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). On univariate analysis, patients with PNI-positive disease had significantly worse 5-year disease-free survival (DFS) (56% versus 68%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), locoregional control (LRC) (62% versus 72%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), and overall survival (OS) (57% versus 75%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) as compared to patients with PNI-negative disease. On multivariate analysis, PNI was significant factor only for OS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.05), not for DFS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.152) or LRC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.174). For PNI-positive cohort, patients with perinodal extension had poor OS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PNI-positive disease had poor outcomes despite aggressive multimodality treatment. PNI positivity correlated with higher pT stage, pN stage, overall stage and poor differentiation. PNI may be considered an independent prognostic factor for OS in oral cavity cancers and should be evaluated further in a randomized controlled setting. Added presence of perinodal extension defines poor outcomes. Sub-classification of PNI may be tested for determining impact on outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_471_24","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:05:14Z","timestamp":1790773514000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of perineural invasion and histopathological features\/clinical outcomes for carcinoma oral cavity: An analysis of 781 patients"],"prefix":"10.4103","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-3703","authenticated-orcid":false,"given":"Nikhil","family":"Kalyani","sequence":"first","affiliation":[{"name":"Department of Oncology, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, 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Hospital and Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0020-5047","authenticated-orcid":false,"given":"Ashay","family":"Karpe","sequence":"additional","affiliation":[{"name":"Department of Oncology, Vedant Hospital, Thane, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2948-1878","authenticated-orcid":false,"given":"Farhana","family":"Girkar","sequence":"additional","affiliation":[{"name":"Department of Oncology, Vedant Hospital, Thane, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4178-8258","authenticated-orcid":false,"given":"Saurabh","family":"Chalke","sequence":"additional","affiliation":[{"name":"Department of Oncology, Vedant Hospital, Thane, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1677-5348","authenticated-orcid":false,"given":"Rakesh","family":"Katna","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India"},{"name":"Department of Oncology, Vedant Hospital, Thane, Maharashtra, India"},{"name":"Department of Oncology, Bombay Hospital and Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of Mumbai Oncology Group \u2013 Head and Neck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"R1-20260930","doi-asserted-by":"crossref","first-page":".520","DOI":"10.1016\/j.clon.2019.05.013","article-title":"Oral cavity cancer in the indian subcontinent \u2013 Challenges and 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