{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:41:50Z","timestamp":1787071310808,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Twenty-five percent of all aggressive angiomyolipomas (AMLs) are related to tuberous sclerosis. Our patient was a 42-year-old man with tuberous sclerosis and a medical history of a benign AML in the left kidney. Presently, an epithelioid AML was detected in his right kidney and, despite our conducting extensive surgery, a large pulmonary metastasis with mediastinal lymph node involvement followed 20 months later. Close follow-up of the patient is advised when epithelioid cells are observed in angiomyolipoma. Immunohistochemistry for mismatch repair proteins showed that PMS2, MSH2, and MSH6 were absent in both the tumor and normal kidney. Microsatellite instability may contribute along with a mutation of\n                    <jats:italic toggle=\"yes\">TSC<\/jats:italic>\n                    gene to the oncogenic events leading to AML.\n                  <\/jats:p>","DOI":"10.4103\/ijc.ijc_501_21","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:29Z","timestamp":1750982429000},"page":"149-152","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Renal epithelioid aggressive angiomyolipoma in a patient with tuberous sclerosis and past contralateral benign renal angiomyolipoma"],"prefix":"10.4103","volume":"62","author":[{"given":"Irene","family":"Pecorella","sequence":"first","affiliation":[{"name":"Department of Radiological, Oncological and Anatomical Pathology Sciences, Umberto I Hospital, Sapienza University of Rome, Viale Regina Elena, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7400-9468","authenticated-orcid":false,"given":"Andrea","family":"Tornese","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Anatomical Pathology Sciences, Umberto I Hospital, Sapienza University of Rome, Viale Regina Elena, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Rullo","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Anatomical Pathology Sciences, Umberto I Hospital, Sapienza University of Rome, Viale Regina Elena, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"R1-20250627","doi-asserted-by":"crossref","first-page":"e1006242","DOI":"10.1371\/journal.pgen.1006242","article-title":"Whole exome sequencing identifies TSC1\/TSC2 Biallelic loss as the primary and sufficient driver event for renal angiomyolipoma development","volume":"5","author":"Giannikou","year":"2016","journal-title":"PLoS Genet"},{"key":"R2-20250627","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1259\/bjr\/98449202","article-title":"Aggressive renal angiomyolipoma extending into the renal vein and inferior vena cava \u2014An uncommon entity","volume":"84","author":"Bakshi","year":"2011","journal-title":"British J Radiol"},{"key":"R3-20250627","first-page":"240","article-title":"Aggressive renal angiomyolipoma: Radiological and pathological correlation","volume":"5","author":"Yiu","year":"2002","journal-title":"JHK Coll Radiol"},{"key":"R4-20250627","first-page":"607","article-title":"Renal angiomyolipoma with lymph node involvement: A case report and literature review","volume":"26","author":"Lin","year":"2003","journal-title":"Chang Gung Med J"},{"key":"R5-20250627","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1442-2042.2004.00909.x","article-title":"Angiomyolipoma of kidney involving the inferior vena cava","volume":"11","author":"Islam","year":"2004","journal-title":"Int J Urol"},{"key":"R6-20250627","first-page":"1077","article-title":"Clinicopathologic features of renal epithelioid angiomyolipoma: Report of one case and review of literatures","volume":"8","author":"Tan","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"R8-20250627","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/modpathol.3880275","article-title":"Concurrent angiomyolipoma and renal cell neoplasia: A study of 36 cases","volume":"14","author":"Jimenez","year":"2001","journal-title":"Mod Pathol"},{"key":"R9-20250627","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s11255-017-1629-4","article-title":"Clinical presentations and molecular studies of invasive renal epithelioid angiomyolipoma","volume":"49","author":"Chuang","year":"2017","journal-title":"Int Urol Nephrol"},{"key":"R10-20250627","doi-asserted-by":"crossref","first-page":"10030","DOI":"10.1038\/srep10030","article-title":"A four-year follow-up study of renal epithelioid angiomyolipoma: A multi-center experience and literature review","volume":"5","author":"Lei","year":"2015","journal-title":"Sci Rep"},{"key":"R11-20250627","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000011805","article-title":"Primary kidney malignant epithelioid angiomyolipoma. Two cases report and review of literature","volume":"97","author":"Zhan","year":"2018","journal-title":"Medicine"},{"key":"R12-20250627","first-page":"9446","article-title":"Immunohistochemistry of p53 and Ki-67 and p53 mutation analysis in renal epithelioid angiomyolipoma","volume":"8","author":"Li","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"R13-20250627","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4103\/0973-1482.136672","article-title":"Pure epitheliod perivascular epitheloid cell tumor (epitheliod angiomyolipoma) of kidney: Case report and literature review","volume":"10","author":"Jayaprakash","year":"2014","journal-title":"J Canc Res Ther"},{"key":"R14-20250627","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/modpathol.2017.144","article-title":"t (6;11) renal cell carcinoma: A study of seven cases including two with aggressive behavior, and utility of CD68 (PG-M1) in the differential diagnosis with pure epithelioid PEComa\/epithelioid angiomyolipoma","volume":"31","author":"Cali\u00f2","year":"2018","journal-title":"Mod Pathol"},{"key":"R15-20250627","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0046-8177(99)90008-4","article-title":"Chromosomal analysis of renal angiomyolipoma by comparative genomic hybridization: Evidence for clonal origin","volume":"30","author":"Kattar","year":"1999","journal-title":"Hum Pathol"},{"key":"R16-20250627","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.humpath.2006.01.028","article-title":"Pathological and molecular analysis of sporadic hepatic angiomyolipoma","volume":"37","author":"Xu","year":"2006","journal-title":"Hum Pathol"},{"key":"R17-20250627","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1056\/NEJM198809013190901","article-title":"Genetic alterations during colorectal-tumor development","volume":"319","author":"Vogelstein","year":"1988","journal-title":"N Engl J Med"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_501_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:27Z","timestamp":1787067867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_501_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_501_21","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2021-05-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}