{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:23:57Z","timestamp":1787765037584,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Clear cell urothelial carcinoma is a rare variant of urothelial carcinoma. It\u2019s recognition and accurate diagnosis are essential in deciding appropriate treatment protocols considering the prognosis of this variant. A 57-year-old male presented with a history of hematuria and lower urinary tract symptoms for 6 months. Microscopically, the tumor was arranged in sheets and had a nested pattern. The tumor was composed of round to polygonal cells with abundant clear cytoplasm (&gt;90% clear cell differentiation), resembling a conventional clear renal cell carcinoma. On special stain, the tumor was positive for periodic acid\u2013Schiff (PAS) and negative for periodic acid\u2013Schiff with diastase (PAS-D) and mucicarmine stain. The urothelial origin of clear cells was confirmed by positivity for GATA Binding protein 3(GATA3) and High Molecular Weight Cytokeratin (HMWCK) immunohistochemistry and negativity for NK3 homeobox 1(NKX3.1), Prostate specific antigen (PSA) and Paired box gene 8 (PAX8) immunohistochemistry.<\/jats:p>","DOI":"10.4103\/ijc.ijc_564_21","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T22:00:07Z","timestamp":1703541607000},"page":"575-577","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Clear cell urothelial carcinoma of bladder: Case report of a rare and aggressive variant with review of literature"],"prefix":"10.4103","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1271-7681","authenticated-orcid":false,"given":"Khushboo M.","family":"Sahetia","sequence":"first","affiliation":[{"name":"Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-9172","authenticated-orcid":false,"given":"Vinayak N.","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1871-9171","authenticated-orcid":false,"given":"Mahendra","family":"Pal","sequence":"additional","affiliation":[{"name":"Surgery Uro-Oncology Disease Management Group, Tata Memorial Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-0671","authenticated-orcid":false,"given":"Santosh","family":"Menon","sequence":"additional","affiliation":[{"name":"Pathology Uro-Oncology Diseases Management Group, Tata Memorial Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.eururo.2016.02.028","article-title":"The 2016 WHO classification of tumours of the urinary system and male genital organs-part B: Prostate and bladder tumours","volume":"70","author":"Humphrey","year":"2016","journal-title":"Eur Urol"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.euf.2019.09.003","article-title":"What is the significance of variant histology in urothelial carcinoma?","volume":"6","author":"Lobo","year":"2020","journal-title":"Eur Urol Focus"},{"key":"R3-20240828","first-page":"79","article-title":"Transitional cell carcinoma exhibiting clear cell features. 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