{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:02Z","timestamp":1787772422155,"version":"build-2784847793"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Kimura\u2019s disease is a rare inflammatory disease that usually appears in head and neck region. We reported natural history of the disease and treatment outcome of radiotherapy (RT) in Chiang Mai University Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective review was performed for all Kimura\u2019s disease patients treated with radiotherapy at our center between 2002 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 20 patients with Kimura\u2019s disease were reviewed. There were 14 men and 6 women. All patients presented with the mass in head and neck region. Eleven patients were treated with a definitive intent with RT, 9 patients were treated with RT after recurrence from other modalities. All patients were treated with local external beam RT with 2 Gy per fraction to a median total dose of 30 Gy (range 30\u201340). The median follow-up time was 4 years (range 1\u201316.5 years). One patient died from HIV opportunistic infection after 1.5 year of radiation with complete response of Kimura\u2019s disease. Most of the patients responded to radiotherapy and controlled the disease at the time of analysis. Two patients had multiple recurrences at new areas outside radiotherapy field. Skin toxicity grade 1 was the most common late side effect which was found in 8 (44%) patients. We did not find severe late toxicity or second malignancy in this patient cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Good local control of Kimura\u2019s disease can be achieved, with a radiation dose of 30\u201340 Gy, with insignificant late toxicities. We suggest that radiotherapy should be one of the treatments of choice for Kimura\u2019s disease both in primary or recurrence setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_69_20","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T04:25:28Z","timestamp":1628310328000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Natural history and treatment outcome of radiotherapy for Kimura\u2019s disease"],"prefix":"10.4103","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-6146","authenticated-orcid":false,"given":"Pooriwat","family":"Muangwong","sequence":"first","affiliation":[{"name":"Divisions of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-0149","authenticated-orcid":false,"given":"Imjai","family":"Chitapanarux","sequence":"additional","affiliation":[{"name":"Divisions of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charin","family":"Ya-in","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-4772","authenticated-orcid":false,"given":"Hanpon","family":"Klibngern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-1540","authenticated-orcid":false,"given":"Pailin","family":"Kongmebhol","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1017\/S0022215100128750","article-title":"Kimura's disease:Case report and brief review of the literature","volume":"108","author":"Nyrop","year":"1994","journal-title":"J Laryngol Otol"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.joms.2005.10.043","article-title":"Kimura's disease of the parotid region:Report of 2 cases and review of the literature","volume":"65","author":"Meningaud","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000478-200404000-00010","article-title":"Kimura disease:A clinicopathologic study of 21 cases","volume":"28","author":"Chen","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bjoms.2004.11.023","article-title":"Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease","volume":"43","author":"Ramchandani","year":"2005","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-4632.2004.02361.x","article-title":"Kimura's disease and angiolymphoid hyperplasia with eosinophilia:Two disease entities in the same patient:Case report and review of the literature","volume":"45","author":"Chong","year":"2006","journal-title":"Int J Dermatol"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0360-3016(97)00813-4","article-title":"Radiotherapy for Kimura's disease:The optimum dosage","volume":"40","author":"Hareyama","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R7-20240828","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.alit.2015.10.008","article-title":"A case of refractory Kimura disease with a buccal bulky mass successfully treated with low-dose cyclosporine A:Report and review of the literature","volume":"65","author":"Miki","year":"2016","journal-title":"Allergol Int"},{"key":"R8-20240828","doi-asserted-by":"crossref","first-page":"e921","DOI":"10.1542\/peds.2006-0487","article-title":"Combined treatment of steroids and cyclosporine in Kimura disease","volume":"118","author":"Sato","year":"2006","journal-title":"Pediatrics"},{"key":"R9-20240828","first-page":"1001","article-title":"Radiotherapy in Kimura's disease:A report of eight cases","volume":"90","author":"Chitapanarux","year":"2007","journal-title":"J Med Assoc Thail"},{"key":"R10-20240828","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European organization for research and treatment of cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R11-20240828","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3174\/ajnr.A2854","article-title":"Kimura Disease:CT and MR imaging findings","volume":"33","author":"Park","year":"2012","journal-title":"Am J Neuroradiol"},{"key":"R12-20240828","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/SCS.0000000000002337","article-title":"Comparison of local recurrence rate of three treatment modalities for Kimura disease","volume":"27","author":"Ye","year":"2016","journal-title":"J Craniofac Surg"},{"key":"R13-20240828","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.ijrobp.2006.02.024","article-title":"Outcomes of Kimura's disease after radiotherapy or nonradiotherapeutic treatment modalities","volume":"65","author":"Chang","year":"2006","journal-title":"Int J Radiat Oncol"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_69_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:45:45Z","timestamp":1787769945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_69_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,7]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_69_20","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,7]]},"assertion":[{"value":"2020-01-29","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}