{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:43:27Z","timestamp":1787071407768,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u201cLineage switch\u201d is a term used to describe the phenomenon of change of lineage of acute leukemia to a different lineage. It is typically seen during therapy or at the time of relapse. More commonly, it is described in the pediatric population with an incidence of 6\u20139%. Lineage switches, though uncommon, can occur from acute myeloid leukemia (AML) to acute lymphoblastic leukemia (ALL (B\/T)) and vice versa. The present scenario of AML to B-ALL switch is rare in an adult, with only a handful of cases described in literature. We report herein a case diagnosed as AML at 56 years of age, with NPM mutation who relapsed after 18 months post initial diagnosis. The clinicopathological features, flowcytometry, and molecular characteristics are discussed.<\/jats:p>","DOI":"10.4103\/ijc.ijc_69_22","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T07:00:15Z","timestamp":1763794815000},"page":"445-448","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Lineage switch of acute myeloid leukemia to B-lymphoblastic leukemia in an adult at relapse with review of literature"],"prefix":"10.4103","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-3125","authenticated-orcid":false,"given":"Manasi C.","family":"Mundada","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Basvatarakam Indo American Cancer Hospital and Research Institute, Rd No 10 Banjara Hills Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5269-6870","authenticated-orcid":false,"given":"Bharath","family":"Potturu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Basvatarakam Indo American Cancer Hospital and Research Institute, Rd No 10 Banjara Hills Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-4697","authenticated-orcid":false,"given":"Faiq","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Basvatarakam Indo American Cancer Hospital and Research Institute, Rd No 10 Banjara Hills Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyella Pavan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Basvatarakam Indo American Cancer Hospital and Research Institute, Rd No 10 Banjara Hills Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"R1-20251122","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/joah.joah_64_19","article-title":"The intriguing occurrence of acute myeloid leukemia in a case of acute lymphoblastic leukemia:Report of two cases","volume":"11","author":"Mundada","year":"2020","journal-title":"J Appl Hematol"},{"key":"R2-20251122","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ajcp\/aqx055","article-title":"Lineage switch between B-lymphoblastic leukemia and acute myeloid leukemia intermediated by \u201coccult\u201d myelodysplastic neoplasm two cases of adult patients with evidence of genomic instability and clonal selection by chemotherapy","volume":"148","author":"Wu","year":"2017","journal-title":"Am J Clin Pathol"},{"key":"R3-20251122","first-page":"81","article-title":"Erythroleukemia 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leukaemia","volume":"89","author":"Boeckx","year":"2004","journal-title":"Haematologica"},{"key":"R7-20251122","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1600-0609.1985.tb01717.x","article-title":"Phenotypic conversion of TdT+adult AML to CALLA+ALL","volume":"35","author":"Marcus","year":"1985","journal-title":"Scand J Haematol"},{"key":"R8-20251122","first-page":"ECR09","article-title":"Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia","volume":"91","author":"Germano","year":"2006","journal-title":"Haematologica"},{"key":"R9-20251122","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1080\/10428190500086055","article-title":"Congenital MLL-positive B-cell acute lymphoblastic leukemia (B-ALL) switched lineage at relapse to acute myelocytic leukemia (AML) with persistent t (4;11) and t (1;6) translocations and JH gene rearrangement","volume":"46","author":"Jiang","year":"2005","journal-title":"Leuk 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