{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:01Z","timestamp":1787840281491,"version":"build-2784847793"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Non-immunoglobulin intracytoplasmic inclusions in plasma cells of multiple myeloma are very rare presentation. These are morphologically similar to Auer rods but chemically different from them. We studied two cases of multiple myeloma in a 60-year-old woman and 45-year-old man. In both cases, plasma cells of bone marrow aspirate revealed multiple Auer rod-like inclusions (ARLI). Sudan black B (SBB) and myeloperoxidase (MPO) cytochemistry were negative. Serum protein electrophoresis in both of them showed M spike, one with raised IgA-kappa levels, while the other with raised IgG-kappa levels. Very few case reports have been published in the literature and its prognostic implications are still unknown. Due to its rarity, it is important to distinguish such cases from acute myeloid leukemia and its exact incidence with its therapeutic and prognostic implications.<\/jats:p>","DOI":"10.4103\/ijc.ijc_741_20","type":"journal-article","created":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T11:11:10Z","timestamp":1632049870000},"page":"110-114","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Auer rod-like inclusions in multiple myeloma: Report of two diagnostically challenging cases"],"prefix":"10.4103","volume":"59","author":[{"given":"Arpita","family":"Mathur","sequence":"first","affiliation":[{"name":"Department of Pathology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pathology-Haematopathology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Talwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,9,19]]},"reference":[{"key":"R1-20250603","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1182\/blood.V49.5.693.693","article-title":"Abnormalities in granule formation in acute myelogenous leukemia","volume":"49","author":"Bainton","year":"1977","journal-title":"Blood"},{"key":"R2-20250603","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12288-016-0744-1","article-title":"Multiple Auer rod like inclusions in multiple myeloma","volume":"33","author":"Tejwani","year":"2017","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R3-20250603","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4103\/IJPM.IJPM_80_17","article-title":"Intracytoplasmic inclusions in plasma cells: A diagnostic adjunct in monoclonal gammopathy of undetermined significance","volume":"60","author":"Gajendra","year":"2017","journal-title":"Indian J Pathol Microbiol"},{"key":"R4-20250603","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4103\/joah.joah_7_18","article-title":"Plasma cell leukemia with a multiple Auer rod-like","volume":"9","author":"Alkhayat","year":"2018","journal-title":"J Appl Hematol"},{"key":"R5-20250603","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1751-553X.2007.01023.x","article-title":"Auer rod-like intracytoplasmic inclusions in multiple myeloma. A case report and review of the literature","volume":"31","author":"H\u00fctter","year":"2009","journal-title":"Int J Lab Hematol"},{"key":"R6-20250603","first-page":"561","article-title":"Auer rod-like inclusions in myeloma cells in a patient with IgG multiple myeloma","volume":"49","author":"Das","year":"2006","journal-title":"Indian J Pathol Microbiol"},{"key":"R7-20250603","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s12288-015-0622-2","article-title":"Occurrence of double monoclonal bands on protein electrophoresis: An unusual finding","volume":"32","author":"Srinivasan","year":"2016","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R8-20250603","doi-asserted-by":"crossref","first-page":"315289","DOI":"10.1155\/2015\/315289","article-title":"Plasmablastic lymphoma: A review of current knowledge and future directions","volume":"2015","author":"Elyamany","year":"2015","journal-title":"Adv Hematol"},{"key":"R9-20250603","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12308-014-0227-y","article-title":"Plasmablastic lymphoma versus diffuse large B cell lymphoma with plasmablastic differentiation: Proposal for a novel diagnostic scoring system","volume":"8","author":"Boy","year":"2015","journal-title":"J Hematopathol"},{"key":"R10-20250603","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3960\/jslrt.17035","article-title":"Anaplastic multiple myeloma: Possible limitations of conventional chemotherapy for long-term remission","volume":"58","author":"Ichikawa","year":"2018","journal-title":"J Clin Exp Hematop"},{"key":"R11-20250603","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1182\/blood-2013-06-504647","article-title":"Auer rod-like inclusions in \u03ba light chain myeloma","volume":"122","author":"Noujaim","year":"2013","journal-title":"Blood"},{"key":"R12-20250603","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.2147\/OTT.S95818","article-title":"Cytogenetic abnormality in patients with multiple myeloma analyzed by fluorescent in situ hybridization","volume":"9","author":"Hu","year":"2016","journal-title":"Onco Targets Ther"},{"key":"R13-20250603","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/01913129809032279","article-title":"Clinical analysis of the prognostic value of ultrastructural abnormalities of plasma cells in patients with multiple myeloma","volume":"22","author":"Kurabayashi","year":"1998","journal-title":"Ultrastruct Pathol"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_741_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:19:13Z","timestamp":1787836753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_741_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,19]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_741_20","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,19]]},"assertion":[{"value":"2020-07-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}