{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:07:45Z","timestamp":1786738065486,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Cancer"],"published-print":{"date-parts":[[2021]]},"DOI":"10.4103\/ijc.ijc_764_18","type":"journal-article","created":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T11:11:10Z","timestamp":1632049870000},"page":"511","source":"Crossref","is-referenced-by-count":5,"title":["Pancreatic exocrine insufficiency occurs in most patients following pancreaticoduodenectomy"],"prefix":"10.4103","volume":"58","author":[{"given":"Mallika","family":"Tewari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ThogariK","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SP","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0019-509X.326249-1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11894-007-0005-4","article-title":"Pancreatic enzyme therapy for pancreatic exocrine insufficiency","author":"Dominguez-Munoz","year":"2007","journal-title":"Curr Gastroenterol Rep"},{"key":"key-10.4103\/0019-509X.326249-2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.dld.2015.06.015","article-title":"Pancreatic exocrine insufficiency in pancreatic cancer.A review of the literature","author":"Bartel","year":"2015","journal-title":"Dig Liver Dis"},{"key":"key-10.4103\/0019-509X.326249-3","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/00006676-198709000-00020","article-title":"Pure pancreatic juice collection over 24 consecutive hours","author":"Gullo","year":"1987","journal-title":"Pancreas"},{"key":"key-10.4103\/0019-509X.326249-4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0016-5085(81)90007-X","article-title":"Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing\/sodium dodecyl sulfate gel electrophoresis","author":"Scheele","year":"1981","journal-title":"Gastroenterology"},{"key":"key-10.4103\/0019-509X.326249-5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0016-5085(84)90132-X","article-title":"Sham feeding and pancreatic secretion.Evidence for direct vagal stimulation of enzyme output","author":"Anagnostides","year":"1984","journal-title":"Gastroenterology"},{"key":"key-10.4103\/0019-509X.326249-6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/1097-0142(19830715)52:2<346::AID-CNCR2820520228>3.0.CO;2-Z","article-title":"Assessment of weight loss, food intake, fat metabolism, malabsorption, and treatment of pancreatic insufficiency in pancreatic cancer","author":"Perez","year":"1983","journal-title":"Cancer"},{"key":"key-10.4103\/0019-509X.326249-7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/BF01303211","article-title":"Release of cholecystokinin and exocrine pancreatic secretion in response to an elemental diet in human subjects","author":"Watanabe","year":"1986","journal-title":"Dig Dis Sci"},{"key":"key-10.4103\/0019-509X.326249-8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00006676-199701000-00012","article-title":"Intraduodenal free fatty acids rather than triglycerides are responsible for the release of CCK in humans","author":"Guimbaud","year":"1997","journal-title":"Pancreas"},{"key":"key-10.4103\/0019-509X.326249-9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0016-5085(98)70640-7","article-title":"Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release","author":"Hildebrand","year":"1998","journal-title":"Gastroenterology"},{"key":"key-10.4103\/0019-509X.326249-10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/2050640613476500","article-title":"Synopsis of recent guidelines on pancreatic exocrine insufficiency","author":"L\u00f9hr","year":"2013","journal-title":"United European Gastroenterol J"},{"key":"key-10.4103\/0019-509X.326249-11","unstructured":"L\u00f9hr JM. Pancreatic Exocrine Insufficiency. 2nd ed. Bremen, Germany: Unimed; 2010."},{"key":"key-10.4103\/0019-509X.326249-12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/mpa.0b013e31805d01b0","article-title":"Mechanisms and emerging treatments of the metabolic complications of chronic pancreatitis","author":"Andersen","year":"2007","journal-title":"Pancreas"},{"key":"key-10.4103\/0019-509X.326249-13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1440-1746.2010.06600.x","article-title":"Pancreatic exocrine insufficiency, diagnosis and treatment","author":"Dom\u00ednguez-Mu\u00f1oz","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"key-10.4103\/0019-509X.326249-14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1067\/mpd.2002.124829","article-title":"How useful is fecal pancreatic elastase 1 as a marker of exocrine pancreatic disease?","author":"Beharry","year":"2002","journal-title":"J Pediatr"},{"key":"key-10.4103\/0019-509X.326249-15","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00000658-198009000-00005","article-title":"Preservation of the pylorus in pancreatico duodenectomy, a follow-up evaluation","author":"Traverso","year":"1980","journal-title":"Ann Surg"},{"key":"key-10.4103\/0019-509X.326249-16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00534-005-1067-z","article-title":"Gastrointestinal function and quality of life after pylorus-preserving pancreatoduodenectomy","author":"Ohtsuka","year":"2006","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"key-10.4103\/0019-509X.326249-17","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/bjs.8813","article-title":"Comparison of 30-day, 90-day and in-hospital postoperative mortality for eight different cancer types","author":"Damhuis","year":"2012","journal-title":"Br J Surg"},{"key":"key-10.4103\/0019-509X.326249-18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.hpb.2015.11.003","article-title":"Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection","author":"Lim","year":"2016","journal-title":"HPB (Oxford)"},{"key":"key-10.4103\/0019-509X.326249-19","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1159\/000066095","article-title":"Deficiencies of micronutrients, altered bowel function, and quality of life during late follow-up after pancreaticoduodenectomy for malignancy","author":"Armstronga","year":"2002","journal-title":"Pancreatology"},{"key":"key-10.4103\/0019-509X.326249-20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1159\/000333308","article-title":"Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: A prospective study","author":"Halloran","year":"2011","journal-title":"Pancreatology"},{"key":"key-10.4103\/0019-509X.326249-21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1159\/000264638","article-title":"Functional changes after pancreatoduodenectomy: Diagnosis and treatment","author":"Tran","year":"2009","journal-title":"Pancreatol"},{"key":"key-10.4103\/0019-509X.326249-22","first-page":"109","article-title":"Prospective assessment of the influence of pancreatic cancer resection on exocrine pancreatic function","author":"Sikkens","year":"2014","journal-title":"Br J Surg"},{"key":"key-10.4103\/0019-509X.326249-23","first-page":"434","article-title":"Functional and morphological changes in the pancreatic remnant following pancreaticoduodenectomy with pancreaticogastric anastomosis","author":"Lemaire","year":"2000","journal-title":"Br J Surg"},{"key":"key-10.4103\/0019-509X.326249-24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1023\/A:1023433509956","article-title":"Analysis of elastase 1 for evaluation of excretory function of the pancreas after gastropancreatoduodenal resection","author":"Lyubimova","year":"2003","journal-title":"Bull Exp Biol Med"},{"key":"key-10.4103\/0019-509X.326249-25","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S1072-7515(02)01126-2","article-title":"Permeability and functionality of pancreaticogastrostomy after pancreaticoduodenectomy with dynamic magnetic resonance pancreatography after secretin stimulation","author":"Pessaux","year":"2002","journal-title":"J Am Coll Surg"},{"key":"key-10.4103\/0019-509X.326249-26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00006676-199903000-00013","article-title":"Accuracy of the plasma amino acid-consumption test in detecting pancreatic diseases is due to different methods","author":"Mariani","year":"1999","journal-title":"Pancreas"},{"key":"key-10.4103\/0019-509X.326249-27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4251\/wjgo.v6.i9.325","article-title":"Considerations on pancreatic exocrine function after Pancreaticoduodenectomy","author":"Morera-Ocon","year":"2014","journal-title":"World J Gastrointest Oncol"},{"key":"key-10.4103\/0019-509X.326249-28","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s11605-011-1805-2","article-title":"Late complications after pancreaticoduodenectomy with pancreaticogastrostomy","author":"Bock","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"key-10.4103\/0019-509X.326249-29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0002-9610(98)00144-5","article-title":"Duct-parenchymal ratio predicts exocrine pancreatic function after pancreatoduodenectomy and distal pancreatectomy","author":"Sato","year":"1998","journal-title":"Am J Surg"},{"key":"key-10.4103\/0019-509X.326249-30","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s00595-007-3507-7","article-title":"Long-term assessments after pancreaticoduodenectomy with pancreatic duct invagination anastomosis","author":"Fujino","year":"2007","journal-title":"Surg Today"},{"key":"key-10.4103\/0019-509X.326249-31","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/00000658-200006000-00014","article-title":"Quality of life and outcomes after pancreaticoduodenectomy","author":"Huang","year":"2000","journal-title":"Ann Surg"},{"key":"key-10.4103\/0019-509X.326249-32","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s11605-012-1927-1","article-title":"Sikkens EC, Cahen DL, van Eijck C, Kuipers EJ, Bruno MJ.The daily practice of pancreatic enzyme replacement therapy after pancreatic surgery: A northern European survey: Enzyme replacement after surgery","author":"Sikkens","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"key-10.4103\/0019-509X.326249-33","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/SLA.0000000000001732","article-title":"Evidence-based guidelines for the management of exocrine pancreatic insufficiency after pancreatic surgery","author":"Sabater","year":"2016","journal-title":"Ann Surg"},{"key":"key-10.4103\/0019-509X.326249-34","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/ajg.2010.201","article-title":"Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial","author":"Whitcomb","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"key-10.4103\/0019-509X.326249-35","doi-asserted-by":"crossref","unstructured":"Seiler CM, Izbicki J, Varga-Szab\u00f3 L, Czak\u00f3 L, Fi\u00f3k J, Sperti C, et al. Randomised clinical trial: A 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a 1-year open-label extension. Aliment Pharmacol Ther 2013;37:691-702.","DOI":"10.1111\/apt.12236"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:04:21Z","timestamp":1786734261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.IJC_764_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"alternative-id":["326249"],"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_764_18","relation":{},"ISSN":["0019-509X"],"issn-type":[{"value":"0019-509X","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]}}}