{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:19:59Z","timestamp":1788542399507,"version":"build-2803163510"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There are very limited studies examining the sexual dysfunction in female rectal cancer treated with curative chemoradiotherapy (CRT). So, we aimed to evaluate the self-related sexual life quality and vaginal dose-volume relationship in female rectal cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The patients who had been treated with chemoradiotherpay between January 2012 and January 2019 were included. Vaginal contouring was performed according to the Radiation Therapy Oncology Group female pelvic normal tissue contouring atlas. Sexual functioning was evaluated by the European Organization for Research and Treatment Quality of life Questionnaire for Sexual Function Modules (EORTC QOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fourty five disease-free female patients volunteered to participate in this study were evaluated. The mean total EORTC QOL score of patients was 19.44 points. The score was &lt;19.44 points accepted as worse sexual functioning and \u226519.44 points accepted as better sexual functioning. We did not find any relationship between sexual functioning and radiotherapy sequence, radiotherapy technique, and total radiotherapy doses. The proximity to anal verge and older patients age were the associated factors for worse sexual functioning in female rectal cancer. Dmin, Dmean, V35, V40, V45, and V50 of vagina were the predictive factors for sexual functioning. According to multivariate regression analyses only the primary tumor distance to anal verge (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01), and V50 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) of vagina were the predictive factors for sexual functioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Sexual dysfunctions in female rectal cancer were associated with tumor distance to anal verge, patients age, Dmean, Dmin, and V35-50 of vagina in female rectal cancer treated with curative radiochemotherapy.<\/jats:p>\n                  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Sakarya Training and Research Hospital, Sakarya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5784-3469","authenticated-orcid":false,"given":"Ozlem","family":"Ay","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-1284","authenticated-orcid":false,"given":"Oztun","family":"Temelli","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Inonu University, Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-7037","authenticated-orcid":false,"given":"Eda Yirmibesoglu","family":"Erkal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-0364","authenticated-orcid":false,"given":"Durmus","family":"Etiz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Eskisehir Osmangazi University, Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0405-7536","authenticated-orcid":false,"given":"Haldun Sukru","family":"Erkal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Yeni Yuzyil University, Gaziosmanpasa Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"R1-20260904","first-page":"233","article-title":"Colorectal Cancer Statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J 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