{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:01Z","timestamp":1787840341171,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adrenocortical tumors are rare tumors in childhood. Virilization is the most common symptom, but about 5.5% of patients may also present with isolated Cushing\u2019s syndrome. A girl 15 years and 8 months of age presented with complaints of striae on her legs, acne for 2 weeks, and amenorrhea for 2 months. On physical examination, extensive striae were observed on her legs and abdomen. On hormonal investigation, her adrenocorticotropic hormone level was &lt;5 pg\/ml, cortisol was 35.4 \u00b5g\/dl. Her hypercortisolism raised suspicion of Cushing\u2019s syndrome. Adrenal MRI revealed a right adrenal mass approximately 9 cm in diameter. Pleural metastasis was detected and the patient was diagnosed as having stage 4 adrenocortical carcinoma. Despite treatment, she died 9 months after diagnosis. Our case followed an aggressive clinical course and was unique due to the presence of extensive striae without pronounced virilization or Cushingoid symptoms.<\/jats:p>","DOI":"10.4103\/ijc.ijc_87_24","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:01:53Z","timestamp":1773046913000},"page":"548-551","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Adrenocortical carcinoma presenting with extensive striae: A case report and literature review"],"prefix":"10.4103","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3625-2387","authenticated-orcid":false,"given":"Ayse","family":"Ozden","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Atat\u00fcrk University School of Medicine, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1847-9844","authenticated-orcid":false,"given":"Zerrin","family":"Orbak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Atat\u00fcrk University School of Medicine, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0632-3527","authenticated-orcid":false,"given":"Ebru","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Pathology, Atat\u00fcrk University School of Medicine, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-8456","authenticated-orcid":false,"given":"Gozde","family":"Doymus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Atat\u00fcrk University School of Medicine, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-3649","authenticated-orcid":false,"given":"Hakan","family":"Doneray","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Atat\u00fcrk University School of Medicine, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"R1-20260309","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1210\/er.2013-1029","article-title":"Adrenocortical carcinoma","volume":"35","author":"Else","year":"2014","journal-title":"Endocr Rev"},{"issue":"Suppl 1","key":"R2-20260309","doi-asserted-by":"crossref","first-page":"e756s","DOI":"10.6061\/clinics\/2018\/e756s","article-title":"Primary malignant tumors of the adrenal glands","volume":"73","author":"Almeida","year":"2018","journal-title":"Clinics (Sao Paulo)"},{"key":"R3-20260309","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000488855","article-title":"Adrenocortical carcinoma in children. A clinicopathological analysis of 41 patients at the Mayo Clinic from 1950 to 2017","volume":"90","author":"Gupta","year":"2018","journal-title":"Horm Res Paediatr"},{"key":"R4-20260309","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ecl.2018.02.008","article-title":"Cushing's syndrome in pediatrics","volume":"47","author":"Lodish","year":"2018","journal-title":"An update. Endocrinol Metab Clin North Am"},{"key":"R5-20260309","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.jpedsurg.2016.07.014","article-title":"Weineke criteria, Ki-67 index and p53 status to study pediatric adrenocortical tumors: Is there a correlation?","volume":"51","author":"Das","year":"2016","journal-title":"J Pediatr Surg"},{"key":"R6-20260309","first-page":"1313","article-title":"Non-androgen secreting adrenocortical carcinoma in preadolescence: A case repor tand literat\u00fcre review","volume":"29","author":"Narumi","year":"2016","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R7-20260309","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000134829","article-title":"Cushing syndrome caused by adrenocortical tumors and hyperplasias (corticotropin- \u0131ndependent cushing syndrome)","volume":"13","author":"Stratakis","year":"2008","journal-title":"Endocr Dev"},{"key":"R8-20260309","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1677\/erc.1.01029","article-title":"Management of patients with adrenal cancer: Recommendations of an international consensus conference","volume":"12","author":"Schteingart","year":"2005","journal-title":"Endocrine-Related Cancer"},{"key":"R9-20260309","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1590\/1984-0462\/;2019;37;1;00002","article-title":"Adrenal carc\u0131noma \u0131n children: Longitud\u0131nal study \u0131n minas gerais Braz\u0131l","volume":"37","author":"Monteiro","year":"2019","journal-title":"Rev Paul Pediatr"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_87_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:20:54Z","timestamp":1787836854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_87_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_87_24","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-02-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}