{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:18Z","timestamp":1787841318756,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Composite tumors are defined as tumors in which there are two different intermixed histologic types. Our objective was to study the clinical and pathologic features of five cases of composite lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>Our study included five patients of composite lymphoma diagnosed over a period of 5 years. Clinical presentation, hematological parameters including peripheral smear, bone marrow aspirate, and histopathological examination of lymph node including immunohistochemistry (IHC) were studied. Treatment and follow-up details were also noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>All the five cases were in the adult age group ranging from 44 to 72 years. All the cases were composite follicular lymphoma (FL) and mixed cellularity classical Hodgkin lymphoma (CHL). Diagnosis in all cases was suspected on morphology by identification of distinct neoplastic follicles in FL and classic Reed\u2013Sternberg cells in CHL and confirmed by IHC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Although rare, composite lymphomas should be kept in mind. Careful histopathological examination of lymph node with identification of distinct morphological features along with IHC helps to arrive at the definitive diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijc.ijc_89_17","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:43:22Z","timestamp":1513817002000},"page":"358-361","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Composite lymphomas: Experience from a tertiary cancer center in Kerala, South India"],"prefix":"10.4103","volume":"54","author":[{"given":"JA","family":"Vasudevan","sequence":"first","affiliation":[{"name":"Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RA","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SG","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"R1-20250920","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5858\/2006-130-107-CLHLAP","article-title":"Composite lymphocyte-rich Hodgkin lymphoma and peripheral T-cell lymphoma associated with Epstein-Barr virus: A case report and review of the literature","volume":"130","author":"Sanchez","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1182\/blood.V88.2.657.bloodjournal882657","article-title":"Nodular lymphocyte-predominant Hodgkin's disease associated with large-cell lymphoma: Analysis of Ig gene rearrangements by V-J polymerase chain reaction","volume":"88","author":"Greiner","year":"1996","journal-title":"Blood"},{"key":"R3-20250920","first-page":"171","article-title":"Review article composite lymphoma","volume":"19","author":"Mokhtar","year":"2007","journal-title":"J Egypt Natl Canc Inst"},{"key":"R4-20250920","first-page":"294","article-title":"Pathology case of the month. A mediastinal mass. Malignant lymphoma, composite (nodular sclerosis Hodgkin lymphoma and diffuse large B-cell lymphoma)","volume":"156","author":"Wei","year":"2004","journal-title":"J La State Med Soc"},{"key":"R5-20250920","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/ajcp\/96.1.81","article-title":"Composite lymphoma. A clinicopathologic analysis of nine patients with Hodgkin's disease and B-cell non-Hodgkin's lymphoma","volume":"96","author":"Gonzalez","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"R6-20250920","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1182\/blood.V71.6.1615.1615","article-title":"Cytogenetic features of Hodgkin's disease suggest possible origin from a lymphocyte","volume":"71","author":"Cabanillas","year":"1988","journal-title":"Blood"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/1097-0142(19850215)55:4<683::AID-CNCR2820550402>3.0.CO;2-O","article-title":"Morphologic, immunologic, enzymohistochemical chromosomal analysis of a cell line derived from Hodgkin's disease. Evidence for a B-cell origin of Reed-Sternberg cells","volume":"55","author":"Poppema","year":"1985","journal-title":"Cancer"},{"key":"R8-20250920","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.annpat.2007.09.001","article-title":"Composite lymphoma: Association of a follicular lymphoma and a chronic lymphocytic leukemia","volume":"28","author":"Rabiller","year":"2008","journal-title":"Ann Pathol"},{"key":"R9-20250920","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/MEG.0b013e3282f4b238","article-title":"Composite marginal zone B cell lymphoma and enteropathy-type T cell lymphoma of the stomach: A case report","volume":"20","author":"Yun","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R10-20250920","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2257.2006.00859.x","article-title":"Composite splenic marginal zone lymphoma and classic Hodgkin lymphoma \u2013 An unusual combination","volume":"29","author":"Elmahy","year":"2007","journal-title":"Int J Lab Hematol"},{"key":"R11-20250920","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1136\/jcp.2005.030825","article-title":"Three coexisting lymphomas in one patient: Genetically related or only a coincidence?","volume":"59","author":"Steinhoff","year":"2006","journal-title":"J Clin Pathol"},{"key":"R12-20250920","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1182\/blood.V100.4.1425.h81602001425_1425_1429","article-title":"Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma","volume":"100","author":"van den Berg","year":"2002","journal-title":"Blood"},{"key":"R13-20250920","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00000478-199101000-00004","article-title":"Chronic lymphocytic leukemia with coexistent Hodgkin's disease. Implications for the origin of the Reed-Sternberg cell","volume":"15","author":"Williams","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"R14-20250920","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.humpath.2007.08.023","article-title":"A 3-way collision tumor of the upper respiratory tract: A composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma","volume":"39","author":"Wang","year":"2008","journal-title":"Hum Pathol"},{"issue":"Suppl 1","key":"R15-20250920","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/annonc\/5.suppl_1.S7","article-title":"The interrelationship between Hodgkin's disease and non-Hodgkin's lymphomas","volume":"5","author":"Jaffe","year":"1994","journal-title":"Ann Oncol"},{"key":"R16-20250920","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1532\/IJH97.03156","article-title":"Epstein-Barr virus-associated composite lymphoma composed of peripheral T-cell lymphoma and an anaplastic variant of a diffuse large B-cell type of non-Hodgkin's lymphoma and strongly expressing p53 protein","volume":"79","author":"Hirose","year":"2004","journal-title":"Int J Hematol"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223310-201754010-00073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:49:38Z","timestamp":1787838578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223310-201754010-00073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_89_17","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}