{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:40:10Z","timestamp":1790667610327,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"\n Background:<\/jats:title>\n Long-term survivors of Hodgkin lymphoma (HL) are at risk of developing a range of late effects, with a second malignant neoplasm and cardiovascular diseases being the leading causes of death in these patients. The present study aims to evaluate the late side effects in children with HL.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Out of 53 HL patients, we assessed the long-term effects of childhood HL survivors (HLSs;\n n<\/jats:italic>\n = 50) diagnosed between 1998 and 2019. Patient data related to chronic health conditions, and sociodemographic characteristics were compared with their siblings (\n n<\/jats:italic>\n = 56).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The cumulative overall survival (OS) at 1, 5, and 10 years from diagnosis was 98.1 \u00b1 1.9%, 93.3 \u00b1 3.8%, and 93.3 \u00b1 3.8%, respectively. Groups of HLSs and their siblings were matched according to age and gender. Compared with siblings, survivors had will be changed as \u2018a higher frequency of nephrotoxicity (\n P<\/jats:italic>\n = 0.02)\u2019, cardiotoxicity (\n P<\/jats:italic>\n = 0.12), thyroid dysfunction (\n P<\/jats:italic>\n = 0.001), health care service usage (\n P<\/jats:italic>\n < 0.01), limitation of physical function (\n P<\/jats:italic>\n = 0.01), and pulmonary disease (\n P<\/jats:italic>\n = 0.01). The control group of siblings had a higher incidence of marital status (\n P<\/jats:italic>\n < 0.01), parenthood (\n P<\/jats:italic>\n = 0.01), and smoking habit (\n P<\/jats:italic>\n = 0.03). Thyroid dysfunction was associated with neck radiotherapy (\n P<\/jats:italic>\n < 0.01). No secondary neoplasm was detected. In relapsed, refractory setting (\n n<\/jats:italic>\n = 10), autologous transplantation (\n n<\/jats:italic>\n = 9) is performed after a complete remission. Brentuximab vedotin with or without bendamustine and rituximab is also used in selected patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Increased number of chronic health conditions and social problems point to the significance of long-term follow-up of HLSs. We are currently preparing a survivorship guideline appropriate for Turkey\u2019s conditions.<\/jats:p>\n <\/jats:sec>\n \n Implications for Cancer Survivors:<\/jats:title>\n Renal, heart, pulmonary impairment, thyroid dysfunction, limitation in physical functioning, and deterioration in social status (marriage, having children, education).<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijc.ijc_912_20","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T01:03:28Z","timestamp":1726016608000},"page":"282-289","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of late effects during a 21-year follow-up of pediatric Hodgkin lymphoma survivors: Experience of a pediatric cancer center in Turkey, as a developing country model"],"prefix":"10.4103","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5573-4659","authenticated-orcid":false,"given":"Nurdan","family":"Tacyildiz","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3730-0982","authenticated-orcid":false,"given":"Hatice M","family":"Cakmak","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-2341","authenticated-orcid":false,"given":"Emel","family":"Unal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1015-6784","authenticated-orcid":false,"given":"Handan","family":"Dincaslan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-2078","authenticated-orcid":false,"given":"Gulsah","family":"Tany\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2863-901X","authenticated-orcid":false,"given":"Sonay \u0130","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8848-741X","authenticated-orcid":false,"given":"\u00d6mer","family":"Kartal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, G\u00fclhane Training and Research Hospital, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4811-5750","authenticated-orcid":false,"given":"Yasin","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-5351","authenticated-orcid":false,"given":"Gulsan","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-1009","authenticated-orcid":false,"given":"I\u015f\u0131nsu","family":"Kuzu","sequence":"additional","affiliation":[{"name":"Department of Patology, Ankara University Faculty of Medicine, Ankara \/Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"R1-20260426","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1182\/blood-2015-07-641035","article-title":"Hodgkin lymphoma in children and adolescents: Improving the therapeutic 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History"}},{"value":"2021-03-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}