{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:43:30Z","timestamp":1787071410131,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myeloid sarcoma (MS) refers to an extramedullary collection of immature cells of granulocytic series and occurs either in isolation or in association with myeloid malignancies, particularly acute myeloid leukemia (AML). We report a 16-year old girl with AML who was treated at our hospital with standard \u201c7 + 3\u201d induction chemotherapy and achieved morphological remission. She developed a small nodule below her right eyelid at day 10 of first consolidation chemotherapy with high-dose cytarabine. Eyelid lesion increased in size despite oral antibiotics. Peripheral blood did not show any blasts. However, bone marrow examination was consistent with relapsed AML. She was treated with salvage chemotherapy followed by allogeneic stem cell transplant. However, her disease relapsed 2 months later and she died. This is the first case of eyelid MS from India in which eyelid MS developed during chemotherapy for AML and heralded the subsequent disease relapse. Eyelid MS could be a sinister manifestation of AML. Literature regarding eyelid MS is discussed in brief.<\/jats:p>","DOI":"10.4103\/ijc.ijc_980_21","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T07:00:25Z","timestamp":1763794825000},"page":"432-435","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Eyelid myeloid sarcoma heralding relapse of acute myeloid leukemia in a child: First report from India and literature review"],"prefix":"10.4103","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-6873","authenticated-orcid":false,"given":"Ankur","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Hematology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-8075","authenticated-orcid":false,"given":"Pooja","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Hematology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-2014","authenticated-orcid":false,"given":"Sumita","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Hematology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Hematology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumita","family":"Saluja","sequence":"additional","affiliation":[{"name":"Department of Hematology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"R1-20251122","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1182\/blood-2011-04-347229","article-title":"How I treat extramedullary acute myeloid leukemia","volume":"118","author":"Bakst","year":"2011","journal-title":"Blood"},{"issue":"(Suppl 1)","key":"R2-20251122","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s12288-016-0656-0","article-title":"Shoulder myeloid sarcoma:An initial presentation of CML blast crisis","volume":"32","author":"Jain","year":"2016","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R3-20251122","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0002-9394(98)00363-8","article-title":"Ocular adnexal granulocytic sarcoma as the first sign of acute myelogenous leukemia relapse","volume":"127","author":"Yaghouti","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"R4-20251122","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0002-9394(75)90326-8","article-title":"Ophthalmologic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma). The third Pan American Association of Ophthalmology and American Journal of Ophthalmology Lecture","volume":"80","author":"Zimmerman","year":"1975","journal-title":"Am J Ophthalmol"},{"key":"R5-20251122","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/IOP.0b013e318073cf70","article-title":"Isolated myeloid sarcoma presenting in all four eyelids","volume":"23","author":"Thomas","year":"2007","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"R6-20251122","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/01676830.2014.938169","article-title":"Eyelid myeloid sarcoma:Ominous presentation of acute myelogenous leukemia","volume":"34","author":"Phelps","year":"2015","journal-title":"Orbit"},{"key":"R7-20251122","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000443202","article-title":"Myeloid sarcoma in an eyelid that developed during chemotherapy for acute myeloid leukemia","volume":"7","author":"Kang","year":"2016","journal-title":"Case Rep Ophthalmol"},{"key":"R8-20251122","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/DAD.0000000000000531","article-title":"Bilateral aleukemic myeloid sarcoma of the eyelids with indolent course","volume":"38","author":"Iliadis","year":"2016","journal-title":"Am J Dermatopathol"},{"key":"R9-20251122","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.18240\/ijo.2019.08.21","article-title":"Myeloid sarcoma of the eyelid mimicking pre-septal cellulitis in acute myeloid leukemia","volume":"12","author":"Park","year":"2019","journal-title":"Int J Ophthalmol"},{"key":"R10-20251122","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0161-6420(86)33534-6","article-title":"Acute monocytic leukemia presenting in the eyelid. An immunohistochemical and electron microscopic study","volume":"93","author":"Thall","year":"1986","journal-title":"Ophthalmology"},{"key":"R11-20251122","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3928\/0191-3913-19931101-10","article-title":"Granulocytic sarcoma of the eyelid as a presenting sign of leukemia","volume":"30","author":"Ford","year":"1993","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"R12-20251122","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1542\/peds.2004-0782","article-title":"Eyelid mass as the presenting finding in a child with Down syndrome and acute megakaryoblastic leukemia","volume":"115","author":"Sandoval","year":"2005","journal-title":"Pediatrics"},{"key":"R13-20251122","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.sjopt.2012.03.004","article-title":"Unilateral eyelid swelling, proptosis and diplopia as initial manifestation of acute myeloid leukemia","volume":"26","author":"Chaudhry","year":"2012","journal-title":"Saudi J Ophthalmol"},{"key":"R14-20251122","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3341\/jkos.2016.57.5.843","article-title":"Case of acute myeloid leukemia with mass of eyelid and conjunctiva in the early stage","volume":"57","author":"Kim","year":"2016","journal-title":"J Korean Opthalmol Soc"},{"key":"R15-20251122","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/ccr3.1175","article-title":"Isolated myeloid sarcoma as the first manifestation of acute myeloid leukemia:A case study","volume":"5","author":"Mitkowski","year":"2017","journal-title":"Clin Case Rep"},{"key":"R16-20251122","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-222659","article-title":"Multifocal myeloid sarcomas:A rare presentation of AML","volume":"2017","author":"Angsubhakorn","year":"2017","journal-title":"BMJ Case Rep"}],"container-title":["Indian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_980_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:43Z","timestamp":1787067943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijc.ijc_980_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijc.ijc_980_21","relation":{},"ISSN":["0019-509X","1998-4774"],"issn-type":[{"value":"0019-509X","type":"print"},{"value":"1998-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2021-08-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}