{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:40Z","timestamp":1787169940302,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Septic shock is the leading cause of acute kidney injury (AKI) in critically ill patients. The foundation of early septic shock management includes early fluid resuscitation, but the association between fluid resuscitation rates and kidney outcomes remains unclear. This investigation examines the association between fluid resuscitation rate and AKI recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In the medical intensive care unit of Mayo Clinic Rochester, adult patients with AKI and septic shock were retrospectively studied from January 1, 2006 to May 31, 2018. The surviving sepsis campaign recommends an initial fluid bolus of 30 ml\/kg for sepsis resuscitation. The cohort of patients was divided into three groups based on the average fluid resuscitation time (&lt;1 h, 1.1\u20133 h, &gt;3 h) and the corresponding fluid rate \u22650.5, 0.17\u20130.49, and &lt;0.17 ml\/kg\/min, respectively. The primary outcome was the recovery of AKI on day 7. To account for potential confounders, multivariable regression analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After meeting the eligibility, 597 patients were included in the analysis. The AKI recovery was considerably different among the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006). Patients in group 1 who received fluid resuscitation faster had a higher rate of AKI recovery (53%) compared to group 2 and group 3 (50% and 37.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      In septic shock patients with AKI, a higher fluid resuscitation rate of 30 ml\/kg IV fluids within the 1\n                      <jats:sup>st<\/jats:sup>\n                      -h sepsis diagnosis (i.e., &gt;0.50 ml\/kg\/min) lead to higher AKI recovery compared with slower infusion rates.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijciis.ijciis_7_23","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T08:10:27Z","timestamp":1695197427000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between the rate of fluid resuscitation and acute kidney injury: A retrospective cohort study"],"prefix":"10.4103","volume":"13","author":[{"given":"Swetha","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kianoush","family":"Kashani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"Department of Medicine, Division of Nephrology and hypertension, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"R1-20240902","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis:For the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"R2-20240902","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","article-title":"Assessment of the worldwide burden of critical illness:The intensive care over nations (ICON) audit","volume":"2","author":"Vincent","year":"2014","journal-title":"Lancet Respir Med"},{"key":"R4-20240902","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.294.7.813","article-title":"Acute renal failure in critically ill patients:A multinational, multicenter study","volume":"294","author":"Uchino","year":"2005","journal-title":"JAMA"},{"key":"R5-20240902","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2215\/CJN.03681106","article-title":"Septic acute kidney injury in critically ill patients:Clinical characteristics and outcomes","volume":"2","author":"Bagshaw","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"R6-20240902","first-page":"293","article-title":"Prognostic factors in acute renal failure due to sepsis","volume":"11","author":"Neveu","year":"1996","journal-title":"Results of a prospective multicentre study. 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