{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:00Z","timestamp":1786728420421,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chandipura virus (CHPV) has reemerged as a serious human pathogen related with acute encephalitis outbreaks. CHPV infection has been detected in various parts of Western, Central, and South India. In India, from June to August 2024, there were 245 reported cases of acute encephalitis syndrome (AES) with 82 deaths and 64 confirmed cases of CHPV; being the largest outbreak in the recent times.\n                    <jats:italic toggle=\"yes\">Phlebotomus<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Sergentomyia<\/jats:italic>\n                    species of sandflies have been identified as potential vectors. The virus has been detected in the whole blood and\/or CSF of patients using reverse-transcriptase polymerase chain reaction, apart from detecting IgM and IgG by ELISA. No specific treatment is available and management relies on symptomatic care and vector control. Surveillance of AES cases across 36 States\/UTs is implemented through Integrated Disease Surveillance Program of the Government of India. Awareness programs on the management of CHPV should be conducted for healthcare workers, especially where the disease has been endemic. Education programs on CHPV should be streamed in the media and rural areas. Vector control is essential to prevent the infection. Hence, a collaborative, \u201cOne Health approach\u201d is necessary for prevention and control. Moreover, research efforts are focused on developing diagnostics, vaccines, and antivirals, with two potential vaccines awaiting clinical trials.\n                  <\/jats:p>","DOI":"10.4103\/ijcm.ijcm_175_25","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:03:31Z","timestamp":1778504611000},"page":"S432-S435","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Chandipura Virus: \u201cThe Silent Threat Emerging in India\u2019s Viral Landscape\u201d"],"prefix":"10.4103","volume":"51","author":[{"given":"D","family":"Bindu","sequence":"first","affiliation":[{"name":"Department of Microbiology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saramma M.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Research and Development Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"R1-20260803","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2012.06.001","article-title":"Chandipura Virus: An emerging tropical pathogen","volume":"124","author":"Menghani","year":"2012","journal-title":"Acta Trop"},{"key":"R2-20260803","doi-asserted-by":"crossref","first-page":"100749","DOI":"10.1016\/j.ijmmb.2024.100749","article-title":"Chandipura virus resurgence: Insights from Indian outbreaks and the path forward","volume":"52","author":"Garg","year":"2024","journal-title":"Indian J Med Microbiol"},{"key":"R3-20260803","first-page":"21","article-title":"Neuropathogenesis by Chandipura virus: An acute encephalitis syndrome in 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antiviral drug evaluation against Chandipura virus infection","volume":"213","author":"Kitaura","year":"2023","journal-title":"Antiviral Res"},{"key":"R14-20260803","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s00705-021-05237-1","article-title":"Cyclophilin A: A possible host modulator in Chandipura virus infection","volume":"166","author":"Pavitrakar","year":"2021","journal-title":"Arch Virol"},{"key":"R15-20260803","article-title":"Remdesivir, Zidovudine (AZT) and Nevirapine Inhibit Chandipura virus replication through high energy interactions with the RdRp domain of the polymerase protein L","author":"Mandal","journal-title":"bioRxiv 2022.03.02.482698"},{"key":"R16-20260803","doi-asserted-by":"crossref","first-page":"014501","DOI":"10.1088\/2752-5309\/ae30f6","article-title":"EpiClim: Weekly district-wise all-India multi-epidemics climate-health dataset for accelerated GeoHealth research","volume":"4","author":"Kaur","year":"2026","journal-title":"Environ Res Health"}],"container-title":["Indian Journal of Community Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijcm.ijcm_175_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:26:49Z","timestamp":1786724809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijcm.ijcm_175_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":13,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijcm.ijcm_175_25","relation":{},"ISSN":["0970-0218","1998-3581"],"issn-type":[{"value":"0970-0218","type":"print"},{"value":"1998-3581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"2025-03-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}