{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:00:12Z","timestamp":1789999212151,"version":"4.0.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Nonadherence to antiretroviral therapy (ART) remains a critical barrier to achieving optimal treatment outcomes among people living with HIV (PLHIV). Understanding multidimensional factors influencing adherence is essential for targeted interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim and Objective:<\/jats:title>\n                    <jats:p>This study aimed to assess determinants of nonadherence to ART among PLHIV attending a tertiary care hospital in Jabalpur, Madhya Pradesh, India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted among 1,067 PLHIV aged \u226518 years receiving ART for \u22656 months at a tertiary care hospital in Jabalpur, Madhya Pradesh. Adherence was assessed using the pill count method, with &lt;95% defined as nonadherence. Data on sociodemographic, patient-related, condition-related, therapy-related, and health system-related factors were collected through structured interviews and medical records review. Chi-square tests and odds ratios were calculated to identify significant associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Nonadherence prevalence was 17.5%. Significant predictors included dissatisfaction with family support (aOR = 38.61), NGO linkage (aOR = 3.82), non-heterosexual transmission routes (aOR = 3.09), current CD4 count &lt;200 cells\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (aOR = 2.90), and age \u226435 years (aOR = 1.51).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study found a 17.5% nonadherence rate among PLHIV on ART in Jabalpur. Younger age, non-heterosexual transmission, poor family support, and low CD4 counts were key predictors. Strengthening social support, addressing stigma, and focusing on vulnerable groups may help improve ART adherence and contribute to progress toward the 95-95-95 targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijcm.ijcm_21_26","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:02:29Z","timestamp":1789750949000},"page":"902-910","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of Antiretroviral Therapy Nonadherence among People Living with HIV: A Cross-sectional Study from a Tertiary Care Hospital in Jabalpur, Madhya Pradesh, India"],"prefix":"10.4103","volume":"51","author":[{"family":"Aprajita","sequence":"first","affiliation":[{"name":"Department of Community Medicine, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prince K.","family":"Lodhi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, 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meta-analysis","volume":"28","author":"Aytenew","year":"2024","journal-title":"AIDS Behav"},{"key":"R11-20260921","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.18203\/2394-6040.ijcmph20184011","article-title":"Anti retroviral therapy adherence and its determinants among patients attending ART centre, Bhopal","volume":"5","author":"Bhagat","year":"2018","journal-title":"Int J Community Med Public Health"},{"key":"R12-20260921","first-page":"2","article-title":"Anti-retroviral therapy adherence in India (2012-18): A systematic review and meta-analysis","volume":"45","author":"Basu","year":"2024","journal-title":"Indian J Sex Transm Dis AIDS"},{"key":"R13-20260921","first-page":"163","article-title":"Socio-demographic profile and adherence to anti-retroviral treatment among HIV\/AIDS patients attending the ART centre in Tamil Nadu","volume":"9","author":"Rajasekar","year":"2023","journal-title":"J Med 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