{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:49Z","timestamp":1787758069637,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Scabies may cause community outbreaks without early diagnosis and appropriate treatment. Oral ivermectin offsets some of the challenges associated with topical 5% permethrin application for treating scabies. We aimed to evaluate the efficacy of two doses of oral ivermectin (200 \u00b5g\/kg) on day one and day seven compared to 5% (weight\/volume [w\/v]) once whole-body application of permethrin lotion in treating scabies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We recruited 100 participants with mild or moderate scabies and randomized them into ivermectin and permethrin arms using computer-generated sequences. Participants and their contacts in the ivermectin arm received two doses of ivermectin (200 \u00b5g\/kg) on day one and day seven. Participants and their contacts in the permethrin arm received treatment with 5% (w\/v) permethrin application over the whole body. The participants were followed up after 4\u20136 weeks of the intervention to determine the cure rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We got a similar cure rate among the scabies patients who received either ivermectin (90.70%) or permethrin (93.33%). The cure rate was 100% after one dose of whole-body application of permethrin or two appropriate doses of ivermectin among mild to moderate cases of scabies. The cost was lower in the ivermectin arm than in the permethrin arm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The cure rates of scabies with one local application of 5% permethrin lotion and two doses of oral ivermectin tablets are similar. Ivermectin has an added advantage that the cost is lower and its usage is convenient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijcm.ijcm_278_24","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T12:00:08Z","timestamp":1744891208000},"page":"969-974","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Two Doses of Ivermectin Tablet in Treatment of Scabies in Comparison to Once Application of 5% Permethrin Lotion \u2013 A Randomized Controlled Trial"],"prefix":"10.4103","volume":"50","author":[{"given":"Debkumar","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyamadhaba","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mythry","family":"Ravichandran","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh P.","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra S.","family":"Sirka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binod K.","family":"Patro","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Taywade","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 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chronic inflammatory skin disease \u2013 strategies for optimizing treatment outcome","volume":"33","author":"Eicher","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R23-20260420","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1684\/ejd.2015.2650","article-title":"Adherence to oral and topical medication in 445 patients with tinea pedis as assessed by the Morisky Medication Adherence Scale-8","volume":"25","author":"Tsunemi","year":"2015","journal-title":"Eur J Dermatol"},{"key":"R24-20260420","first-page":"e42268","article-title":"Development and validation of the ScAbIeS tool for diagnosing scabies by community healthcare workers in resource-limited settings","volume":"15","author":"Behera","year":"2023","journal-title":"Cureus"}],"container-title":["Indian Journal of Community 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