{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:39:27Z","timestamp":1787071167695,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitiligo, affecting 0.25% in India (&gt;1% in Jharkhand), stigmatises and devastates self-esteem\/relationships causing depression. Apart from medical treatment, surgical procedures like applying 5-fluorouracil after microneedling are to be confirmed in unstudied populations and across time periods. An interventional study was conducted among out-patients of a tertiary hospital in a high-prevalence population wherein earlier attempts were not conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims\/Objectives:<\/jats:title>\n                    <jats:p>To assess the effect of microneedling and applying 5% 5-fluorouracil on stable vitiligo patches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>Microneedling and topical application of 5-fluorouracil was planned on 30 subjects of 10\u201350 age-groups with stable vitiligo, from September 2019 to September 2021 every 15 days for 12 visits. Age, gender, site, size\/stability of vitiligo patches, leukotrichia and vitiligo family history were studied. Repigmentation (overall and variable-wise) was measured at each visit using 76\u2013100% (excellent), 51\u201375% (very good), 25 to 50% (good) and &lt;25% (poor). Data was analysed with the Chi-square test or Standard Error of Difference between two proportions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Under COVID restrictions (2020\u20132021), sample coverage was 77% (23\/30) comprising 13 females and 10 males. Visits varied for each subject totalling 185 visits out of an expected 276 (67%). Significantly, 3 (13%) achieved excellent repigmentation, 10 (43%) very good, 8 (35%) good and only 2 (9%) poor repigmentation. Cumulatively, 13 (56%) attained excellent\/very good repigmentation and 21 (91%) had excellent\/very good\/good repigmentation. Repigmentation ranged from 10% to 100% among 23 subjects, averaging 54% in average 8 visits (4 months). Repigmentation was equally achieved irrespective of age, gender, site, size and stability of the vitiliginous patch, presence\/absence of leukotrichia and family history of vitiligo. Manageable pain (100%), itching (4%) and hyperpigmentation 43%, were side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Cumulative 91% (excellent\/very good\/good) repigmentation despite COVID-19 in the study period, and its comparability with other studies, strengthens evidence that microneedling and 5% 5-fluorouracil is effective in treating stable vitiligo in a high prevalence population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_1056_23","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T11:45:48Z","timestamp":1730288748000},"page":"377-384","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Microneedling and 5-Fluorouracil in Treating Stable Vitiligo in Hitherto Unstudied High Prevalence Population"],"prefix":"10.4103","volume":"69","author":[{"given":"B","family":"Abhirami","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Venereology, Leprosy \u2013 Mahatma Gandhi Memorial Medical College and Hospital, Jamshedpur and Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhat","family":"Kumar","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Venereology, Leprosy \u2013 Mahatma Gandhi Memorial Medical College and Hospital, Jamshedpur and Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmendra K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Venereology, Leprosy \u2013 Mahatma Gandhi Memorial Medical College and Hospital, Jamshedpur and Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"R2-20241101","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1755-148X.2012.00997.x","article-title":"Vitiligo global issue consensus conference panelists. 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