{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:38:37Z","timestamp":1790397517091,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"\n Background:<\/jats:title>\n \n Recent highlights have investigated the possible roles of molecular chaperons like heat shock proteins (HSPs) into Lichen Planus (LP)-onset and pathogenesis. This study for the first, determine the expression of both\n HSP60<\/jats:italic>\n and\n HSP70<\/jats:italic>\n genes in cutaneous LP (CLP) and oral LP (OLP) lesions compared to normal healthy cases and between different subtypes of OLP lesions by real-time (RT)-PCR.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Paraffin blocks of LP lesions including 56 OLP and 56 CLP samples were selected from theMashhad University of Medical sciences, Mashhad, Iran. Also 56 biopsy samples of healthy normal participants were selected. The demographic and clinical characteristics were extracted from their medical records. The expression of\n HSP60<\/jats:italic>\n and HPS70 genes were evaluated using the real-time RT-PCR method.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The comparison of the expression of\n HSP60<\/jats:italic>\n and\n HSP70<\/jats:italic>\n genes among the patients with CLP and OLP showed a significant overexpression of\n HSP60<\/jats:italic>\n and\n HSP70<\/jats:italic>\n genes in both groups compared to the normal participants (\n P<\/jats:italic>\n = 0.001). The expression of\n HSP60<\/jats:italic>\n and\n HSP70<\/jats:italic>\n genes was high in both the groups of CLP and OLP patients, but the amount was not significantly different between the two groups. Comparing the two mucosal subgroups of OLP lesions (non-erosive and erosive) showed that the expression of the\n HSP60<\/jats:italic>\n and\n HSP70<\/jats:italic>\n in erosive subtypes of OLP was significantly higher than the non-erosive subtypes of OLP (\n P<\/jats:italic>\n = 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Regarding the overexpression of\n HSP60<\/jats:italic>\n and\n HSP70<\/jats:italic>\n in the LP lesions compared to healthy biopsies, we conclude that\n HSP60<\/jats:italic>\n and\n HSP70<\/jats:italic>\n could have key roles in the etiopathogenesis of the OLP and CLP lesions. The overexpression of both\n HSP60<\/jats:italic>\n and\n HSP70<\/jats:italic>\n in the erosive OLP group compared to the non-erosive OLP group emphasized the possible roles of HSPs in the pathogenesis and premalignant changes of OLP lesions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijd.ijd_1060_20","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T03:01:56Z","timestamp":1649818916000},"page":"591-597","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the Altered Tissue Expression of HSP60 and HSP70 Genes in Oral and Cutaneous Lichen Planus Compared to Normal Healthy Tissues"],"prefix":"10.4103","volume":"66","author":[{"given":"Nooshin","family":"Mohtasham","sequence":"first","affiliation":[{"name":"From the Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Shahabinejad","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Kafiroudi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Mohajertehran","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad, Iran"},{"name":"Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","first-page":"e1","article-title":"Cutaneous, genital and oral lichen planus: 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