{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:43Z","timestamp":1787841343766,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Backgrounds:<\/jats:title>\n                    <jats:p>Mutation of protein-coding genes and non-coding genes is a factor in psoriasis etiology. Non-coding RNA (ncRNA), which does not have protein-coding capacity, is available in the human genome. HOTAIR (HOX Antisense Intergenic RNA) and 7SL-RNA are known as ncRNA. They may play a role in psoriasis pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>In our study, we aimed to investigate the level of HOTAIR and 7SL-RNA gene expression in the lesional and perilesional healthy skin of psoriasis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Total RNA isolation from the skin samples was achieved by modifying the RNeasy Mini Kit (Qiagen, Cat No: 74104) protocol. Real Time Polymerase Chain Reaction (qPCR) phase was performed in accordance with the protocol of the relevant brand (WizPure qPCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>7SL-RNA gene expression decreased in the skin with psoriatic lesions (FC: 0.01; p: 0.028), and this decrease was statistically significant. HOTAIR gene expression decreased (FC: 0.92; p: 0.218), but this decrease was not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>lncRNAs may play a role in the pathogenesis of psoriasis disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_1125_20","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T03:01:56Z","timestamp":1649818916000},"page":"704-704","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Research on Hotair and 7SL-RNA Gene Expression Levels in Psoriasis Vulgaris"],"prefix":"10.4103","volume":"66","author":[{"given":"Seyma","family":"Yaz\u0131c\u0131","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Cumhuriyet University School of Medicine, Sivas, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukiye Yasak","family":"Guner","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Cumhuriyet University School of Medicine, Sivas, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melih","family":"Akyol","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Cumhuriyet University School of Medicine, Sivas, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Burcu","family":"Tuzemen Bayyurt","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Cumhuriyet University School of Medicine, Sivas, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdal","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Cumhuriyet University School of Medicine, Sivas, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/iji.12482","article-title":"A single nucleotide polymorphism within HOX transcript antisense RNA (HOTAIR) is associated with risk of psoriasis","volume":"47","author":"Rakhshan","year":"2020","journal-title":"Int J Immunogenet"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.gene.2018.09.042","article-title":"Genomic alterations driving psoriasis pathogenesis","volume":"683","author":"Singh","year":"2019","journal-title":"Gene"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.0022-202X.2004.23511.x","article-title":"The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis","volume":"124","author":"Allen","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"Suppl 2(Suppl 2)","key":"R4-20250921","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0001-7310(09)73372-1","article-title":"Progress in understanding the immunopathogenesis of psoriasis","volume":"100","author":"Mak","year":"2009","journal-title":"Actas Dermosifiliogr"},{"key":"R5-20250921","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jid.2015.12.009","article-title":"Landscape of long noncoding RNAs in psoriatic and healthy skin","volume":"136","author":"Gupta","year":"2016","journal-title":"J Invest Dermatol"},{"key":"R6-20250921","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12943-020-1147-3","article-title":"Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA","volume":"19","author":"Wu","year":"2020","journal-title":"Mol Cancer"},{"key":"R7-20250921","first-page":"34","article-title":"Long non-coding RNAs (lncRNAs) and viral infections","volume":"3","author":"Zhang","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"R8-20250921","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3389\/fimmu.2017.01053","article-title":"PRINS non-coding RNA regulates nucleic acid-induced innate immune responses of human keratinocytes","volume":"8","author":"Danis","year":"2017","journal-title":"Front Immunol"},{"key":"R9-20250921","first-page":"1","article-title":"HOTAIR: An oncogenic long non-coding RNA in different cancers","volume":"12","author":"Hajjari","year":"2015","journal-title":"Cancer Biol Med"},{"key":"R10-20250921","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbrc.2015.12.082","article-title":"Tumor FOXP3 represses the expression of long noncoding RNA 7SL","volume":"472","author":"Yang","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"R11-20250921","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis pathogenesis and treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"5S","key":"R12-20250921","first-page":"18","article-title":"Psoriasis risk factors and triggers","volume":"102","author":"Lee","year":"2018","journal-title":"Cutis"},{"key":"R13-20250921","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1365-2230.2001.00832.x","article-title":"Psoriasis-Epidemiology and clinical spectrum","volume":"26","author":"Christophers","year":"2001","journal-title":"Clin Exp Dermatol"},{"key":"R14-20250921","doi-asserted-by":"crossref","first-page":"103214","DOI":"10.1016\/j.bioorg.2019.103214","article-title":"The role of long noncoding RNA in major human disease","volume":"92","author":"Zhang","year":"2019","journal-title":"Bioorg Chem"},{"key":"R15-20250921","first-page":"224","article-title":"Exosomal long non-coding RNAs as biomarkers in human diseases","volume":"30","author":"Kelemen","year":"2019","journal-title":"EJIFCC"},{"key":"R16-20250921","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12935-019-0992-x","article-title":"Long non-coding RNA HOTAIR functions as a competitive endogenous RNA to regulate PRAF2 expression by sponging miR-326 in cutaneous squamous cell carcinoma","volume":"19","author":"Yu","year":"2019","journal-title":"Cancer Cell Int"},{"key":"R17-20250921","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.intimp.2017.06.021","article-title":"LncRNA HOTAIR alleviates rheumatoid arthritis by targeting miR-138 and inactivating NF-\u03baB pathway","volume":"50","author":"Zhang","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"R18-20250921","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10238-013-0271-4","article-title":"PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis","volume":"15","author":"Song","year":"2015","journal-title":"Clin Exp Med"},{"key":"R19-20250921","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/art.11484","article-title":"Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy","volume":"50","author":"Kao","year":"2004","journal-title":"Arthritis Rheum"},{"key":"R20-20250921","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11926-018-0732-6","article-title":"Immune-Mediated Necrotizing Myopathy","volume":"20","author":"Pinal-Fernandez","year":"2018","journal-title":"Curr Rheumatol Rep"},{"key":"R21-20250921","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13023-015-0277-y","article-title":"Inflammatory myopathy with anti-signal recognition particle antibodies: Case series of 100 patients","volume":"10","author":"Suzuki","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"R22-20250921","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.gpb.2018.11.004","article-title":"Novel autoantibodies related to cell death and DNA repair pathways in systemic lupus erythematosus","volume":"17","author":"Luo","year":"2019","journal-title":"Genom Proteom Bioinform"},{"key":"R23-20250921","first-page":"1727","article-title":"Novel autoantibodies against 7SL RNA in patients with polymyositis\/dermatomyositis","volume":"32","author":"Satoh","year":"2005","journal-title":"J Rheumatol"},{"key":"R24-20250921","doi-asserted-by":"crossref","first-page":"13112","DOI":"10.1128\/JVI.00892-07","article-title":"7SL RNA Mediates Virion Packaging of the Antiviral Cytidine Deaminase APOBEC3G","volume":"81","author":"Wang","year":"2007","journal-title":"J Virol"},{"key":"R25-20250921","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/bjd.12322","article-title":"Is chronic plaque psoriasis triggered by microbiota in the skin?","volume":"169","author":"Fry","year":"2013","journal-title":"Br J Dermatol"},{"key":"R26-20250921","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1600-0625.2005.00358.x","article-title":"Human papillomavirus type 5 in primary keratinocytes from psoriatic skin","volume":"14","author":"Simeone","year":"2005","journal-title":"Exp Dermatol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_1125_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:49:48Z","timestamp":1787838588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_1125_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_1125_20","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"2020-12-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}