{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:39:20Z","timestamp":1787071160086,"version":"build-2736575974"},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Psoriasis is a common dermatologic disease with multifactorial etiology in which genetic factors play a major role. Peroxisome proliferator-activated receptor (PPAR)-\u03b3 is expressed in keratinocytes and is known to affect cell maturation and differentiation in addition to its role in inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To study the association between PPAR-\u03b3 gene polymorphism and psoriasis vulgaris in Egyptian patients to explore if this polymorphism influenced disease risk or clinical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-five patients with psoriasis vulgaris and 45 age, sex and body mass index matched healthy volunteers who have no present, past or family history of psoriasis as a control group were enrolled. Selected cases included obese and nonobese participants. Detection of PPAR-\u03b3 gene polymorphism was done with restriction fragment length polymorphism polymerase chain reaction. Narrow-band ultraviolet B (NBUVB) was given for every case three times\/week for 12 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Homopolymorphism, heteropolymorphism, and Ala allele were significantly associated with cases (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01, and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004, respectively) and increased risk of occurrence of psoriasis by 5.25, 3.65, and 3.37 folds, respectively. Heteropolymorphism was significantly associated with nonobese cases compared to obese ones (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01). Ala allele was significantly associated with obese cases (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) and increased risk of occurrence of psoriasis in obese participants by 1.14 folds. Homopolymorphism, heteropolymorphism, and Ala allele were more prevalent among obese cases without metabolic syndrome (MS) than obese cases with MS but without statistical significance. Percentage of decrease of mean Psoriasis Area and Severity Index score before and after 3 months of treatment with NBUVB was higher in cases with heteropolymorphism with no significant difference between homo- and heteropolymorphism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PPAR-\u03b3 gene polymorphism is associated with and increased the risk of psoriasis and its associated obesity in Egyptian patients. It has no role in NBUVB response in those patients. Future large-scale studies on different populations are recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_114_18","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T05:11:28Z","timestamp":1559020288000},"page":"192-200","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Peroxisome Proliferator-Activated Receptor-\u03b3 Gene Polymorphism in Psoriasis and Its Relation to Obesity, Metabolic Syndrome, and Narrowband Ultraviolet B Response: A Case\u2013Control Study in Egyptian Patients"],"prefix":"10.4103","volume":"64","author":[{"given":"Iman","family":"Seleit","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Shibeen El Koom, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola Ahmed","family":"Bakry","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Shibeen El Koom, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Abd El Gayed","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Menoufiya University, Shibeen El Koom, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Ghanem","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Shibeen El Koom, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: A systematic review of incidence and prevalence","volume":"133","author":"Parisi","year":"2013","journal-title":"J Invest Dermatol"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/ijdvl.IJDVL_1239_15","article-title":"Prevalence of ocular findings in a sample of Egyptian patients with psoriasis","volume":"84","author":"Omar","year":"2018","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jaad.2008.02.039","article-title":"Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics","volume":"58","author":"Menter","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"R4-20250921","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s004030050338","article-title":"Genetics of psoriasis","volume":"290","author":"Henseler","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"R5-20250921","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4103\/0019-5154.113962","article-title":"Prevalence of metabolic syndrome in South Indian patients with psoriasis vulgaris and the relation between disease severity and metabolic syndrome: A hospital-based case-control study or cross-sectional study?","volume":"58","author":"Thappa","year":"2013","journal-title":"Indian J Dermatol"},{"key":"R6-20250921","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2165\/00128071-200506060-00005","article-title":"The psychosocial burden of psoriasis","volume":"6","author":"Kimball","year":"2005","journal-title":"Am J Clin Dermatol"},{"key":"R7-20250921","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/aje\/kwp104","article-title":"Psychosocial stress and change in weight among US adults","volume":"170","author":"Block","year":"2009","journal-title":"Am J Epidemiol"},{"key":"R8-20250921","first-page":"297","article-title":"Metabolic comorbidities and psoriasis","volume":"18","author":"Gisondi","year":"2010","journal-title":"Acta Dermatovenereol Croat"},{"key":"R9-20250921","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bbalip.2007.02.004","article-title":"Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease","volume":"1771","author":"Michalik","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"R10-20250921","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2165\/00128071-200809010-00002","article-title":"Peroxisome proliferator-activated receptors (PPARs) and the human skin: Importance of PPARs in skin physiology and dermatologic diseases","volume":"9","author":"Sertznig","year":"2008","journal-title":"Am J Clin Dermatol"},{"key":"R11-20250921","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/BOR.0b013e3283031c99","article-title":"Psoriasis and metabolic disease: Epidemiology and pathophysiology","volume":"20","author":"Azfar","year":"2008","journal-title":"Curr Opin Rheumatol"},{"key":"R12-20250921","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1067\/mjd.2001.108376","article-title":"Expression of apoptosis markers on peripheral blood lymphocytes from patients with cutaneous T-cell lymphoma during extracorporeal photochemotherapy","volume":"44","author":"Osella-Abate","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"R13-20250921","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.4049\/jimmunol.177.6.3737","article-title":"Peroxisome proliferator-activated receptor gamma promotes lymphocyte survival through its actions on cellular metabolic activities","volume":"177","author":"Jo","year":"2006","journal-title":"J Immunol"},{"key":"R14-20250921","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00403-011-1159-3","article-title":"Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients","volume":"303","author":"Nakajima","year":"2011","journal-title":"Arch Dermatol Res"},{"key":"R15-20250921","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11010-011-0989-9","article-title":"Anti-angiogenic action of PPAR\u03b3 ligand in human umbilical vein endothelial cells is mediated by PTEN upregulation and VEGFR-2 downregulation","volume":"358","author":"Kim","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"R16-20250921","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1074\/jbc.275.7.4541","article-title":"Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPAR gamma co-associated with transcription factor NFAT","volume":"275","author":"Yang","year":"2000","journal-title":"J Biol Chem"},{"key":"R17-20250921","first-page":"203","article-title":"Critical roles of PPAR gamma in every aspect of the metabolic syndrome","volume":"68","author":"Tanaka","year":"2010","journal-title":"Nihon Rinsho"},{"key":"R18-20250921","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0029665111003181","article-title":"Effect of interaction between PPARG, PPARA and ADIPOQ gene variants and dietary fatty acids on plasma lipid profile and adiponectin concentration in a large intervention study","volume":"71","author":"Al Saleh","year":"2012","journal-title":"Proc Nutr Soc"},{"key":"R19-20250921","doi-asserted-by":"crossref","first-page":"37006","DOI":"10.1074\/jbc.M700447200","article-title":"Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis","volume":"282","author":"Fuenzalida","year":"2007","journal-title":"J Biol Chem"},{"key":"R20-20250921","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1100\/tsw.2010.213","article-title":"The nuclear hormone receptor PPAR\u03b3 as a therapeutic target in major diseases","volume":"10","author":"Schmidt","year":"2010","journal-title":"ScientificWorldJournal"},{"key":"R21-20250921","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/exd.12647","article-title":"The role of PPAR\u03b3-mediated signalling in skin biology and pathology: New targets and opportunities for clinical dermatology","volume":"24","author":"Ramot","year":"2015","journal-title":"Exp Dermatol"},{"key":"R22-20250921","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1046\/j.1523-1747.2001.01329.x","article-title":"Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid","volume":"116","author":"Westergaard","year":"2001","journal-title":"J Invest Dermatol"},{"key":"R23-20250921","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.0022-202X.2004.23235.x","article-title":"Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation","volume":"123","author":"Mao-Qiang","year":"2004","journal-title":"J Invest Dermatol"},{"key":"R24-20250921","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.physiol.65.092101.142528","article-title":"Nuclear receptors and the control of metabolism","volume":"65","author":"Francis","year":"2003","journal-title":"Annu Rev Physiol"},{"key":"R25-20250921","first-page":"1","article-title":"Genetic polymorphism and SNPs: Genotyping, haplotype assembly problem, haplotype map","volume":"3","author":"Smith","year":"2002","journal-title":"Funct Genomic Proteomic"},{"key":"R26-20250921","doi-asserted-by":"crossref","first-page":"114","DOI":"10.7555\/JBR.27.20120061","article-title":"Application of the back-error propagation artificial neural network (BPANN) on genetic variants in the PPAR-\u03b3 and RXR-\u03b1 gene and risk of metabolic syndrome in a Chinese Han population","volume":"28","author":"Zhao","year":"2014","journal-title":"J Biomed Res"},{"key":"R27-20250921","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJM199810013391403","article-title":"Obesity associated with a mutation in a genetic regulator of adipocyte differentiation","volume":"339","author":"Ristow","year":"1998","journal-title":"N Engl J Med"},{"key":"R28-20250921","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/47254","article-title":"Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension","volume":"402","author":"Barroso","year":"1999","journal-title":"Nature"},{"key":"R30-20250921","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ymgme.2004.08.014","article-title":"Impact of genetic variation of PPARgamma in humans","volume":"83","author":"Meirhaeghe","year":"2004","journal-title":"Mol Genet Metab"},{"key":"R31-20250921","first-page":"7","article-title":"A simplified psoriasis area severity index (SPASI) for rating psoriasis severity in clinic patients","volume":"10","author":"Louden","year":"2004","journal-title":"Dermatol Online J"},{"key":"R33-20250921","first-page":"147","article-title":"Quetelet's index (W\/H2) as a measure of fatness","volume":"9","author":"Garrow","year":"1985","journal-title":"Int J Obes"},{"key":"R34-20250921","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"R35-20250921","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4103\/0971-6866.116126","article-title":"Association between PRO12ALA polymorphism of the PPAR-\u03b32 gene and type 2 diabetes mellitus in Iranian patients","volume":"19","author":"Motavallian","year":"2013","journal-title":"Indian J Hum Genet"},{"key":"R36-20250921","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00403-004-0463-6","article-title":"Variations in the genes encoding the peroxisome proliferator-activated receptors alpha and gamma in psoriasis","volume":"296","author":"M\u00f6ssner","year":"2004","journal-title":"Arch Dermatol Res"},{"key":"R37-20250921","first-page":"142","article-title":"Free fatty acids and insulin resistance","volume":"10","author":"Delarue","year":"2007","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"R38-20250921","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/3099","article-title":"A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity","volume":"20","author":"Deeb","year":"1998","journal-title":"Nat Genet"},{"key":"R39-20250921","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.exger.2005.05.004","article-title":"Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors","volume":"40","author":"Barbieri","year":"2005","journal-title":"Exp Gerontol"},{"key":"R40-20250921","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.appet.2007.04.003","article-title":"Polymorphism in the PPARgamma2 and beta2-adrenergic genes and diet lipid effects on body composition, energy expenditure and eating behavior of obese women","volume":"49","author":"Rosado","year":"2007","journal-title":"Appetite"},{"key":"R41-20250921","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.diabres.2008.06.004","article-title":"Effect of ENPP1\/PC-1-K121Q and PPARgamma-pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population","volume":"81","author":"Bouhaha","year":"2008","journal-title":"Diabetes Res Clin Pract"},{"issue":"Suppl 3","key":"R42-20250921","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1038\/sj.ijo.0802803","article-title":"Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents","volume":"28","author":"Ochoa","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"R43-20250921","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.metabol.2004.06.019","article-title":"Effects of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism on body fat distribution in female Korean subjects","volume":"53","author":"Kim","year":"2004","journal-title":"Metabolism"},{"key":"R44-20250921","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/dmrr.543","article-title":"A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 gene with obesity in native Javanese in Indonesia","volume":"21","author":"Danawati","year":"2005","journal-title":"Diabetes Metab Res Rev"},{"key":"R45-20250921","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ymgme.2005.02.004","article-title":"Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population","volume":"85","author":"Meirhaeghe","year":"2005","journal-title":"Mol Genet Metab"},{"key":"R46-20250921","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1590\/S0100-879X2006005000114","article-title":"Effects of a PPARG gene variant on obesity characteristics in Brazil","volume":"40","author":"Mattevi","year":"2007","journal-title":"Braz J Med Biol Res"},{"key":"R47-20250921","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/oby.2008.225","article-title":"Interaction between PPARgamma2 variants and gender on the modulation of body weight","volume":"16","author":"Morini","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"R48-20250921","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1440-1681.2007.04796.x","article-title":"Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects","volume":"35","author":"Li","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"R49-20250921","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/oby.2008.1","article-title":"Impact of peroxisome proliferator-activated receptors gamma and delta on adiposity in toddlers and preschoolers in the GENESIS study","volume":"16","author":"Lagou","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"R50-20250921","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2337\/diabetes.51.3.867","article-title":"The proline 12 alanine substitution in the peroxisome proliferator \u2013 Activated receptor-gamma2 gene is associated with lower lipoprotein lipase activity in vivo","volume":"51","author":"Schneider","year":"2002","journal-title":"Diabetes"},{"key":"R51-20250921","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s125-002-8257-y","article-title":"Reduced lipolysis as possible cause for greater weight gain in subjects with the Pro12Ala polymorphism in PPARgamma2?","volume":"45","author":"Stumvoll","year":"2002","journal-title":"Diabetologia"},{"key":"R52-20250921","doi-asserted-by":"crossref","first-page":"876","DOI":"10.2337\/diabetes.50.4.876","article-title":"Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity","volume":"50","author":"Stumvoll","year":"2001","journal-title":"Diabetes"},{"key":"R53-20250921","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1172\/JCI1235","article-title":"Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese zucker rats","volume":"101","author":"Okuno","year":"1998","journal-title":"J Clin Invest"},{"key":"R54-20250921","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/0026-0495(87)90170-3","article-title":"Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children","volume":"36","author":"Abbott","year":"1987","journal-title":"Metabolism"},{"key":"R55-20250921","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1172\/JCI119870","article-title":"Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation","volume":"100","author":"Adams","year":"1997","journal-title":"J Clin Invest"},{"key":"R56-20250921","article-title":"Body mass index, abdominal fatness, weight gain and the risk of psoriasis: A systematic review and dose-response meta-analysis of prospective studies","author":"Aune","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"R57-20250921","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2337\/diab.47.1.98","article-title":"Depot-specific differences in adipose tissue gene expression in lean and obese subjects","volume":"47","author":"Lefebvre","year":"1998","journal-title":"Diabetes"},{"key":"R58-20250921","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2337\/diabetes.49.6.883","article-title":"The perils of portliness: Causes and consequences of visceral adiposity","volume":"49","author":"Montague","year":"2000","journal-title":"Diabetes"},{"key":"R59-20250921","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s001250051225","article-title":"The PPARgamma2 amino acid polymorphism pro 12 Ala is prevalent in offspring of type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects","volume":"42","author":"Koch","year":"1999","journal-title":"Diabetologia"},{"key":"R60-20250921","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000111512","article-title":"Association between psoriasis and the metabolic syndrome. A cross-sectional study","volume":"216","author":"Cohen","year":"2008","journal-title":"Dermatology"},{"key":"R61-20250921","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00403-006-0703-z","article-title":"Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis","volume":"298","author":"Sommer","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"R62-20250921","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cmet.2006.09.003","article-title":"Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance","volume":"4","author":"Agostini","year":"2006","journal-title":"Cell Metab"},{"key":"R63-20250921","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2337\/diabetes.50.4.891","article-title":"The Pro12Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: Possible involvement in impairment of insulin secretion in individuals with type 2 diabetes","volume":"50","author":"Mori","year":"2001","journal-title":"Diabetes"},{"key":"R64-20250921","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1253\/circj.CJ-09-0320","article-title":"Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: Interaction with smoking status","volume":"73","author":"Tellechea","year":"2009","journal-title":"Circ J"},{"key":"R65-20250921","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1034\/j.1399-0004.2003.00026.x","article-title":"The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: Results from the Qu\u00e9bec Family Study","volume":"63","author":"Robitaille","year":"2003","journal-title":"Clin Genet"},{"key":"R66-20250921","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1684\/ejd.2012.1789","article-title":"Psoriasis and metabolic syndrome: Is peroxisome proliferator-activated receptor-\u03b3 part of the missing link?","volume":"22","author":"Hegazy","year":"2012","journal-title":"Eur J Dermatol"},{"key":"R67-20250921","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.arcmed.2008.11.005","article-title":"Association between two common polymorphisms of PPARgamma gene and metabolic syndrome families in a Chinese population","volume":"40","author":"Yang","year":"2009","journal-title":"Arch Med Res"},{"key":"R68-20250921","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1074\/jbc.M409795200","article-title":"Epidermal peroxisome proliferator-activated receptor gamma as a target for ultraviolet B radiation","volume":"280","author":"Zhang","year":"2005","journal-title":"J Biol Chem"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00076423-201964030-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:42:23Z","timestamp":1787067743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00076423-201964030-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_114_18","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"2018-03-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}