{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:16:49Z","timestamp":1787847409978,"version":"build-2784847793"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      We report a case of annular epidermolytic ichthyosis (AEI) resulting from\n                      <jats:italic toggle=\"yes\">de novo keratin 1<\/jats:italic>\n                      gene mutation. AEI is a rare autosomal dominantly inherited cornification disorder and is a distinct phenotypic variant of bullous congenital ichthyosiform erythroderma. Blisters and erosions in AEI are widespread; hence, initially, it is sometimes mistaken with epidermolysis bullosa, acrodermatitis enteropathica, and staphylococcal scalded skin syndrome. Genetic tests including next-generation sequencing and Sanger sequencing are essential for AEI diagnosis. AEI is treated symptomatically by wound dressing, prevention of infection, and the use of emollients, humectants, and keratolytic products; topical or systemic retinoids may also prove helpful.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_115_20","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T12:52:07Z","timestamp":1623156727000},"page":"224","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Annular Epidermolytic Ichthyosis Resulting from a de Novo Mutation, p.I479T, in Keratin 1 Gene"],"prefix":"10.4103","volume":"66","author":[{"given":"Lihong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-32-20240829","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0190-9622(92)70198-O","article-title":"Annular epidermolytic ichthyosis: A unique phenotype","volume":"27","author":"Sahn","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"R2-32-20240829","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1086\/302278","article-title":"Cyclic ichthyosis with epidermolytic hyperkeratosis: A phenotype conferred by mutations in the 2B domain of keratin K1","volume":"6","author":"Sybert","year":"1999","journal-title":"Am J Hum Genet"},{"key":"R3-32-20240829","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/1523-1747.ep12286491","article-title":"A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma","volume":"108","author":"Joh","year":"1997","journal-title":"J Invest Dermatol"},{"key":"R4-32-20240829","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1046\/j.1523-1747.1998.00451.x","article-title":"A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma","volume":"111","author":"Suga","year":"1998","journal-title":"J Invest Dermatol"},{"key":"R5-32-20240829","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jid.2016.08.018","article-title":"The X-ray crystal structure of the keratin 1-keratin 10 helix 2B heterodimer reveals molecular surface properties and biochemical insights into human skin disease","volume":"137","author":"Bunick","year":"2017","journal-title":"J Invest Dermatol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.IJD_115_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:16:51Z","timestamp":1787843811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.IJD_115_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_115_20","relation":{},"ISSN":["0019-5154"],"issn-type":[{"value":"0019-5154","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}