{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:50:23Z","timestamp":1790041823567,"version":"4.0.1"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects individuals of all ages. While probiotics have been widely studied as a treatment option in children with AD, evidence regarding their efficacy in adults remains limited. To address this gap, we conducted a meta-analysis to evaluate the impact of probiotic supplementation on AD in adult populations. Seven randomized controlled trials (RCTs) were included in the analysis. Compared to placebo, probiotic treatment significantly reduced SCORAD (Scoring Atopic Dermatitis) values (weighted mean difference [WMD], \u22124.52; 95% confidence interval [CI], \u22126.89 to \u22122.15;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001; I\u00b2 = 61.6%). Subgroup analyses indicated that both single-strain and mixed-strain probiotics demonstrated similar trends in SCORAD improvement, although mixed strains did not reach statistical significance. While overall cytokine levels showed no significant change after treatment, notable reductions in interleukin-4 (IL-4) and thymus- and activation-regulated chemokine (TARC) levels were observed (interleukin [IL]-4: WMD, \u22122.35; 95% CI, \u22123.23 to \u22121.47; TARC: WMD, \u22121.10; 95% CI, \u22121.49 to \u22120.71; both\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). These findings suggest that probiotics may offer clinical benefits for adults with AD, potentially by modulating inflammatory responses through the downregulation of IL-4 and TARC.\n                  <\/jats:p>","DOI":"10.4103\/ijd.ijd_117_24","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:01:33Z","timestamp":1747627293000},"page":"221-221","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Probiotics for the Treatment of Atopic Dermatitis in Adults: A Systematic Review and Meta-Analysis"],"prefix":"10.4103","volume":"70","author":[{"given":"Chen","family":"Yingying","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Min","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Jinglin","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qing","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wenlin","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"R1-20250702","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s11882-014-0466-0","article-title":"Microbiome diversity and asthma and allergy risk","volume":"14","author":"Legatzki","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"R2-20250702","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s40264-015-0287-7","article-title":"Topical corticosteroid-induced skin atrophy: A comprehensive review","volume":"38","author":"Barnes","year":"2015","journal-title":"Drug Saf"},{"key":"R3-20250702","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.jaci.2019.11.047","article-title":"Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses","volume":"145","author":"Tsoi","year":"2020","journal-title":"J Allergy Clin 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